Selective kinetic determination of amikacin in serum using long-wavelength fluorimetry

Sánchez-Martínez, M.L.; Aguilar-Caballos, M.P.; Gómez‐Hens, A.

doi:10.1016/j.jpba.2003.11.015

Cited by 14 publications

(6 citation statements)

References 27 publications

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“…The chemical structures of the studied drugs are shown in Table I. A wide variety of analytical methods was reported for determination of these drugs in pure forms, pharmaceutical formulations and biological fluids. These methods include spectrophotometric (3)(4)(5)(6)(7)(8)(9)(10)(11), spectrofluorimetric (12)(13)(14)(15)(16)(17)(18), chemiluminescence (19)(20)(21)(22)(23), thin-layer chromatographic (24)(25)(26), capillary electrophoresis (27)(28)(29), high-performance liquid chromatographic (30)(31)(32)(33)(34), polarographic (35,36), near infrared (37) immunoassay (38,39) and microbiological methods (40)(41)(42). In comparison with the previously published spectrofluorimetric methods that determined these drugs in micrograms per milliliter or nanograms per milliliter levels, the proposed method determines the concerned drugs in picograms per milliliter level.…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Spectrofluorimetric Method for Determination of Certain Aminoglycosides in Pharmaceutical Formulations and Human Plasma

et al. 2013

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A simple, reliable, highly sensitive and selective spectrofluorimetric method has been developed for determination of certain aminoglycosides namely amikacin sulfate, tobramycin, neomycin sulfate, gentamicin sulfate, kanamycin sulfate and streptomycin sulfate. The method is based on the formation of a charge transfer complexes between these drugs and safranin in buffer solution of pH 8. The formed complexes were quantitatively extracted with chloroform under the optimized experimental conditions. These complexes showed an excitation maxima at 519-524 nm and emission maxima at 545-570 nm. The calibration plots were constructed over the range of 4-60 pg mL(-1) for amikacin, 4-50 pg mL(-1) for gentamicin, neomycin and kanamycin, 4-40 pg mL(-1) for streptomycin and 5-50 pg mL(-1) for tobramycin. The proposed method was successfully applied to the analysis of the cited drugs in dosage forms. The proposed method was validated according to ICH and USP guidelines with respect to specificity, linearity, accuracy, precision and robustness. The high sensitivity of the proposed method allowed determination of amikacin and gentamicin in spiked and real human plasma.

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Section: Introductionmentioning

confidence: 99%

Highly Sensitive Spectrofluorimetric Method for Determination of Certain Aminoglycosides in Pharmaceutical Formulations and Human Plasma

et al. 2013

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“…[1] Monitoring of amikacin levels in plasma is required for therapeutic and toxic control, so a simple, sensitive and specific method for trace analysis in plasma is essential. Some methods have been adopted for the determination of amikacin, including immunoassay, [2] spectrophotometry, [3] fluorescence method, [4][5][6] liquid chromatography, [1,[7][8][9][10][11] capillary electrophoresis [12] and CL [13] voltammetry. [14] Because of lack of volatility and chromophore, most methods use derivatization to produce volatile, UV-vis absorbing or fluorescent derivatives.…”

Section: Introductionmentioning

confidence: 99%

New luminol chemiluminescence reaction using diperiodatoargentate as oxidate for the determination of amikacin sulfate

2009

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A new chemiluminescence (CL) reaction between luminol and diperiodatoargentate [K(2) [Ag (H(2)IO(6)) (OH)(2)]] was observed in alkaline medium. The CL intensity could be greatly enhanced by amikacin sulfate. Therefore a new CL method for the determination of amikacin sulfate was built by combining with flow injection technology. A possible mechanism of the CL reaction was proposed via the investigation of the CL kinetic characteristics, the CL spectrum and the UV absorption spectra of some related substance. The concentration range of linear response was 5.1 x 10(-8) to 5.1 x 10(-6)mol L(-1) with a detection limit of 1.9 x 10(-8) mol L(-1) (3sigma). The proposed method had good reproducibility with a relative standard deviation of 2.8% (n = 7) for 5.1 x 10(-7) mol L(-1) of amikacin sulfate. It was successfully applied to determine amikacin sulfate in serum.

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“…A direct LC method based on pulsed electrochemical detection (PED) [4] and an indirect fluorimetric method [14] have also been proposed, while the LC-PED method has been adopted in the recent edition of US Pharmacopoeia [15]. Apart from LC methods, capillary electrophoresis [16], thin layer chromatography [17], kinetic fluorimetry [18] and immunoassays [19] have been successfully applied for the determination of amikacin in various matrices.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a novel LC non-derivatization method for the determination of amikacin in pharmaceuticals based on evaporative light scattering detection

Galanakis

Megoulas

Solich

et al. 2006

Journal of Pharmaceutical and Biomedical Analysis

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Selective kinetic determination of amikacin in serum using long-wavelength fluorimetry

Cited by 14 publications

References 27 publications

Highly Sensitive Spectrofluorimetric Method for Determination of Certain Aminoglycosides in Pharmaceutical Formulations and Human Plasma

Highly Sensitive Spectrofluorimetric Method for Determination of Certain Aminoglycosides in Pharmaceutical Formulations and Human Plasma

New luminol chemiluminescence reaction using diperiodatoargentate as oxidate for the determination of amikacin sulfate

Development and validation of a novel LC non-derivatization method for the determination of amikacin in pharmaceuticals based on evaporative light scattering detection

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