Selective Intrapartum Chemoprophylaxis of Neonatal Group B Streptococcal Early-Onset Disease. I. Epidemiologic Rationale

Boyer, Kenneth M.; Gadzala, Cecile A.; Burd, Larry; Fisher, David E.; Paton, J. N.; Gotoff, Samuel P.

doi:10.1097/00006254-198409000-00007

Cited by 48 publications

(74 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Group B streptococci (GBS)는 신생아 패혈증 및 뇌막염의 주 요 원인 균종으로 감염 환자의 10∼20%가 사망하는 중증 감염 병이며 [1,2], 임신부에서는 조기진통의 원인균 중의 하나로 알 려져 있다 [3,4]. 신생아 GBS 감염의 약 70%는 생후 3일 이내에 발병하며 대부분 출생 시 임신부의 산도에 존재하는 GBS를 흡 인함으로써 발생되고, 지연감염은 대개 생후 7일 이후에 발병 한다 [5,6].…”

Section: 서 론unclassified

Colonization Rate, Serotypes, and Distributions of Macrolide-Lincosamide-Streptogramin_BResistant Types of Group B Streptococci in Pregnant Women

Choi

Jang

et al. 2009

Korean J Clin Microbiol

View full text Add to dashboard Cite

show abstract

Section: 서 론unclassified

Colonization Rate, Serotypes, and Distributions of Macrolide-Lincosamide-Streptogramin_BResistant Types of Group B Streptococci in Pregnant Women

Choi

Jang

et al. 2009

Korean J Clin Microbiol

View full text Add to dashboard Cite

show abstract

“…Furthermore, maternal infection may cause preterm delivery, low birthweight infants or stillbirths (7). GBS colonization is asymptomatic and occurs in a transient, chronic or intermittent manner and the colonization period is variable; therefore, detecting GBS in vaginal tract at certain times of pregnancy could indicate the existence of this bacterium at delivery (8). Performing culture or tests in fewer than five weeks before delivery are relatively accurate for predicting the carrier's situation at the time of delivery (9).…”

Section: Introductionmentioning

confidence: 99%

Direct Identification of Streptococcus agalactiae in Vaginal Colonization in Pregnant Women Using Polymerase Chain Reaction

et al. 2014

View full text Add to dashboard Cite

Background: Streptococcus agalactiae is a commensal organism, but it may cause infection in susceptible hosts including newborns as well as in pregnant or postpartum women. Applying rapid, accurate and sensitive methods for detecting group B Streptococcus (GBS) and receiving intrapartum antibiotic prophylaxis (IAP) at delivery have been demonstrated to increase the treatment possibility of carrier pregnant women and decrease the rates of GBS vertical transmission to infants. Objectives: The aim of this study was to compare the PCR assay results targeting 16S rRNA primers with the conventional culture method for direct detection of GBS in vaginal specimens of pregnant women at 35-37 weeks of gestation in Hamadan, Iran. Patients and Methods: A total of 203 vaginal specimens of pregnant women at 35-37 weeks of pregnancy from June 2013 through February 2014 were evaluated for detection of GBS, using culture method and polymerase chain reaction (PCR). Results: The prevalence of GBS in the 203 collected samples was 7.39% using culture method and 19.70% using PCR. Twenty-five specimens had positive PCR results and negative cultures; two specimens were positive in culture and negative by PCR.A total of 42 specimens (20.69%) were considered as true positive. The PCR results in comparison with culture (as the gold standard) revealed sensitivity of 88.24%, specificity of 87.44%, positive and negative predictive value of 35.71% and 98.95% respectively, and accuracy of 87.50%. Conclusions: Performing only culture method led to missed false negative carriers. Therefore, it is recommended that both the PCR assay and conventional culture method be routinely performed to detect GBS in pregnant women accurately. PCR diagnosis demonstrated a shorter turnaround time when compared with the time consuming culture method.

show abstract

“…Entretanto, quando sinais e sintomas de corioamnionite estão presentes, a incidência aumenta para 3% a 5%. No estudo de Boyer et al 28,29 , a presença de bolsa rota por mais de 18 horas aumentava em quatro vezes o risco de infecção.…”

Section: Discussionunclassified

Indicadores imunológicos (IgM e proteína C-reativa) nas infecções neonatais

Vaz¹,

Ceccon²,

Diniz³

et al. 1998

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

RESUMO -A sepse, no período neonatal, está associada com a presença de fatores de risco para infecção e com o estado imunológico do recém-nascido.OBJETIVO. Verificar, em recém-nascidos com fatores de risco para infecção, o papel da proteína C reativa (PCR) 1 em 1991, é de uma resposta sistêmica à infecção manifestada pelo menos por duas das seguintes condições: hipotermia, hipertermia, taquipnéia e taquicardia, e, laboratorialmente, por alterações na contagem de leucócitos no sangue, dispensando a positividade da hemocultura.O quadro laboratorial de sepse, no período neonatal, permanece muito difícil, e o isolamento de um microorganismo no sangue, no líquor (LCR), na urina ou em qualquer outro local fechado constitui o exame mais específico para o diagnóstico de infecção, embora com alguns inconvenientes, o principal deles sendo o período de incubação da cultura de até 72 horas. Com esse período de incubação, 98% das culturas positivas serão identificadas, com exceção de alguns Staphylococcus coagulase negativos, anaeróbios e fungos 2 . Squire et al.3 , em 1979, mostraram que somente 82% dos RNs com infecção sistêmica comprovada por culturas post-mortem e achados de necropsia tinham culturas positivas in vivo. Visser e Hall 4 relataram que 15% dos RNs com diagnóstico de meningite e com cultura de líquor positiva tinham hemocultura negativa. Portanto, a negatividade da hemocultura não exclui infecção sistêmica.A cultura de urina deve sempre ser colhida de punção suprapúbica para evitar contaminação. É uma técnica relativamente difícil e o crescimento bacteriano demora o mesmo tempo que as outras culturas como a do LCR 5 . Os métodos para detectar a presença de antí-

show abstract

Selective Intrapartum Chemoprophylaxis of Neonatal Group B Streptococcal Early-Onset Disease. I. Epidemiologic Rationale

Cited by 48 publications

References 0 publications

Colonization Rate, Serotypes, and Distributions of Macrolide-Lincosamide-Streptogramin_BResistant Types of Group B Streptococci in Pregnant Women

Colonization Rate, Serotypes, and Distributions of Macrolide-Lincosamide-Streptogramin_BResistant Types of Group B Streptococci in Pregnant Women

Direct Identification of Streptococcus agalactiae in Vaginal Colonization in Pregnant Women Using Polymerase Chain Reaction

Indicadores imunológicos (IgM e proteína C-reativa) nas infecções neonatais

Contact Info

Product

Resources

About

Selective Intrapartum Chemoprophylaxis of Neonatal Group B Streptococcal Early-Onset Disease. I. Epidemiologic Rationale

Cited by 48 publications

References 0 publications

Colonization Rate, Serotypes, and Distributions of Macrolide-Lincosamide-StreptograminBResistant Types of Group B Streptococci in Pregnant Women

Colonization Rate, Serotypes, and Distributions of Macrolide-Lincosamide-StreptograminBResistant Types of Group B Streptococci in Pregnant Women

Direct Identification of Streptococcus agalactiae in Vaginal Colonization in Pregnant Women Using Polymerase Chain Reaction

Indicadores imunológicos (IgM e proteína C-reativa) nas infecções neonatais

Contact Info

Product

Resources

About

Colonization Rate, Serotypes, and Distributions of Macrolide-Lincosamide-Streptogramin_BResistant Types of Group B Streptococci in Pregnant Women

Colonization Rate, Serotypes, and Distributions of Macrolide-Lincosamide-Streptogramin_BResistant Types of Group B Streptococci in Pregnant Women