Selective internal radiation therapy in older patients with hepatocellular carcinoma: a retrospective analysis

Abstract

This retrospective study included all consecutive patients who were treated by SIRT for HCC BLCC (Barcelona-Clinic Liver Cancer) B or C in our institution [5]. Inclusion criteria were age ≥18 years, ECOG ≤2, eligibility to SIRT, Child ≤ B8, treatment in one session, use of glass or resin microsphere. Exclusion criteria were pulmonary estimated dose >30 gy, microspheres' flow in the gastrointestinal tract. This work was accepted by our institutional review board. All procedures performed in studies involving

2022 KLCA-NCC Korea practice guidelines for the management of hepatocellular carcinoma

“…The most common side effect of 90 Y TARE is temporary fatigue and it can be safely performed even in the elderly or patients with large tumors due to less PES and better quality of life compared to TACE. 642,643 Radioembolization-induced liver disease (REILD) usually occurs 4-8 weeks after 90 Y TARE, and the risk factors include small liver (<1.5 L), small functional liver volume associated with liver cirrhosis, systemic therapy within 2 months, and extensive infusion of 90 Y microspheres to both lobes of the liver. [644][645][646] In some patients, delayed hepatotoxicity may occur 6 months after TARE, and http://www.e-cmh.org https://doi.org/10.3350/cmh.2022.0294 it may not be recognized as REILD.…”

2022 KLCA-NCC Korea practice guidelines for the management of hepatocellular carcinoma

“…The most common side effect of 90 Y TARE is temporary fatigue and it can be safely performed even in the elderly or patients with large tumors due to less PES and better quality of life compared to TACE. 642,643 Radioembolization-induced liver disease (REILD) usually occurs 4-8 weeks after 90 Y TARE, and the risk factors include small liver (<1.5 L), small functional liver volume associated with liver cirrhosis, systemic therapy within 2 months, and extensive infusion of 90 Y microspheres to both lobes of the liver. [644][645][646] In some patients, delayed hepatotoxicity may occur 6 months after TARE, and it may not be recognized as REILD.…”

Performance of HCC diagnosis in the KLCA-NCC guidelines: a closer look at MRI contrast agents and HCC imaging hallmarks

“…Further studies are needed to select appropriate patients and to compare 90 Y TARE with other treatments. The most common side effect of 90 Y TARE is temporary fatigue and it can be safely performed even in the elderly or patients with large tumors due to less PES and better quality of life compared to TACE [642,643]. Radioembolizationinduced liver disease (REILD) usually occurs 4-8 weeks after 90 Y TARE, and the risk factors include small liver (< 1.5 L), small functional liver volume associated with liver cirrhosis, systemic therapy within 2 months, and extensive infusion of 90 Y micro-spheres to both lobes of the liver [644][645][646].…”