“…When rats were administered the EGS, the PGE 2 level decreased (Table 1) and the damage to auriculare erythema and tail tubercle was significantly reduced. Since increasing PGE 2 can cause inflammatory reactions, such as local congestion, oedema and pain in RA (Fogel-Petrovic, Long, Knight, Thompson, & Upham, 2004;Kontny, Rudnicka, Kowalczewski, Marcinkiewicz, & Maslinski, 2003), the significant decrease of PGE 2 in rheumatoid rats may be due to inhibition of COX 2 activity following the administration of EGS.…”