2003
DOI: 10.1002/art.10975
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Selective inhibition of cyclooxygenase 2–generated prostaglandin E2 synthesis in rheumatoid arthritis synoviocytes by taurine chloramine

Abstract: Objective. To investigate the effects of taurine chloramine (Tau-Cl), a chlorinated derivative of the amino acid taurine, on the expression of cyclooxygenase (COX) isoenzymes and prostaglandin E 2 (PGE 2 ) synthesis in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS).Methods. FLS, isolated from the synovial tissue of RA patients, were treated in vitro with either interleukin-1␤ (IL-1␤; 1 ng/ml) alone or together with 200-500 M Tau-Cl. The expression of COX isoenzymes was evaluated at both the prote… Show more

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Cited by 29 publications
(12 citation statements)
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References 65 publications
(97 reference statements)
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“…When rats were administered the Gentiana macrophylla extract, the PGE 2 level was apparently decreased (Table 1) and the damage to auriculare erythema and tail tubercle was significantly reduced. Since increasing PGE 2 can cause inflammatory reactions, such as local congestion, edema, and pain in rheumatoid arthritis (Kontny et al, 2003;Fogel-Petrovic et al, 2004), the significant decrease of PGE 2 in rheumatoid rats may be due to inhibition of COX2 activity following the administration of Gentiana macrophylla.…”
Section: Discussionmentioning
confidence: 99%
“…When rats were administered the Gentiana macrophylla extract, the PGE 2 level was apparently decreased (Table 1) and the damage to auriculare erythema and tail tubercle was significantly reduced. Since increasing PGE 2 can cause inflammatory reactions, such as local congestion, edema, and pain in rheumatoid arthritis (Kontny et al, 2003;Fogel-Petrovic et al, 2004), the significant decrease of PGE 2 in rheumatoid rats may be due to inhibition of COX2 activity following the administration of Gentiana macrophylla.…”
Section: Discussionmentioning
confidence: 99%
“…Finally, we propose that due to anti-infl ammatory [25][26][27][28] and anti-proliferative (present results) effects triggered in RA FLS, Tau-Cl may represent the new therapeutic strategy to normalize abnormal behaviour of these cells. Our data showing protection of subcutaneously applied Tau-Cl against development of collagen-induced arthritis in mice [57], provide support for this notion.…”
Section: Discussionmentioning
confidence: 99%
“…The sequence of primers specifi c for p21 and PCR conditions were as described previously [38] with the modifi cation that the primers annealing temperature was performed at 50 °C. The primers specifi c for survivin and for the housekeeping gene encoding glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as well as PCR conditions, were as described previously [27,39]. Under applied conditions, the rate of particular product amplifi cation was within the exponential rate.…”
Section: Reverse Transcriptase-polymerase Chain Reaction (Rt-pcr)mentioning
confidence: 99%
See 1 more Smart Citation
“…When rats were administered the EGS, the PGE 2 level decreased (Table 1) and the damage to auriculare erythema and tail tubercle was significantly reduced. Since increasing PGE 2 can cause inflammatory reactions, such as local congestion, oedema and pain in RA (Fogel-Petrovic, Long, Knight, Thompson, & Upham, 2004;Kontny, Rudnicka, Kowalczewski, Marcinkiewicz, & Maslinski, 2003), the significant decrease of PGE 2 in rheumatoid rats may be due to inhibition of COX 2 activity following the administration of EGS.…”
Section: Chemical Constituentsmentioning
confidence: 96%