Inhibitory effects of the Gentiana macrophylla (Gentianaceae) extract on rheumatoid arthritis of rats

Yu, Farong; Yu, Fahong; Li, Rende; Wang, Rui

doi:10.1016/j.jep.2004.06.025

Cited by 69 publications

(44 citation statements)

References 5 publications

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“…Studies have shown that G. macrophylla extracts possess laxative properties, and its ethanol extract exhibits broad range antimicrobial activity [6]. Often, G. macrophylla, is used in combination with other Gentiana species for maintenance of healthy sinus, and for treating rheumatoid arthritis and osteoporosis [7]. The plant is also used in Chinese herbal medicine for the management of diabetes, osteoporosis and rheumatism [8].However, till date, the use of G. macrophylla in the prevention of osteoporosis has not been validated scientifically.…”

Section: Gentiana Macrophylla Belongs To Familymentioning

confidence: 99%

Gentiana macrophylla Pall (Gentianaceae) extract exerts protective effects against osteoporosis in mice

Gong¹,

Su²,

Xiang³

et al. 2018

Trop. J. Pharm Res

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Purpose: To evaluate the anti-osteoporotic effect of G. macrophylla extract in a mice model. Methods: Antioxidant activity was determined by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) for radical scavenging, nitro-blue tetrazolium (NBT) reducing, and ferric reducing antioxidant power (FRAP) assays using standard biochemical procedures. The expression of some bone-related genes was measured by quantitative real-time polymerase chain reaction (qTR-PCR). Phytochemical analysis was carried out by liquid chromatography-mass spectrometry (LC/MS

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Section: Gentiana Macrophylla Belongs To Familymentioning

confidence: 99%

Gentiana macrophylla Pall (Gentianaceae) extract exerts protective effects against osteoporosis in mice

Gong¹,

Su²,

Xiang³

et al. 2018

Trop. J. Pharm Res

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“…Anaphalis lactea has long been used for invigorating the circulation of blood and for relieving phlegm and hemostasia [24]. Gentiana siphonantha Maxim., a perennial herb in the Gentianaceae family, has been a traditional Chinese medicine for more than 2000 years for the treatment of rheumatoid arthritis, jaundice hepatitis, constipation, pain, and hypertension [25,26,27]. Previous studies on G. siphonantha have shown that this medical herb is rich in iridoids, especially gentiopicroside [28,29], well-known phytochemicals in a number of folk medicinal plants with anti-inflammatory, antibacterial, free radical-scavenging, and hepatoprotective activities [30,31,32,33].…”

Section: Introductionmentioning

confidence: 99%

Antidermatophyte Activity of the Gentiopicroside-Rich n-Butanol Fraction from Gentiana siphonantha Maxim. Root on a Guinea Pig Model of Dermatophytosis

et al. 2018

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Background:Gentiana siphonantha Maxim. is a traditional medicine for the treatment of rheumarthritis, icterepatitis, pain and hypertension; it is rich in gentiopicroside with anti-inflammatory, antibacterial, and free radical-scavenging activities. This study was to evaluate the antidermatophyte activity of G. siphonantha on a guinea pig model in vitro and in vivo. Material andMethods: The antidermatophyte activities of 10 plants were tested by the broth microdilution method. Fractions and an extract of G. siphonantha were tested against Trichophyton mentagrophytes by the disc diffusion method. The morphological changes of T. mentagrophytes were observed. Component analysis of the n-butanol (n-BuOH) fraction was made by HPLC. Finally, the antifungal activity in an in vivo guinea pig model of dermatophytosis was examined. Results:G. siphonantha had strong antidermatophyte activity with MIC₅₀ values of 32-64 μg/mL. The n-BuOH fraction of G. siphonantha showed the most potent activity compared to the other fractions. After being exposed to the n-BuOH fraction at 80 and 160 μg/mL, the hyphae were distorted and collapsed. Gentiopicroside is the main active ingredient in the n-BuOH fraction of G. siphonantha. The lesion scores of the guinea pig model of dermatophytosis significantly declined in the 10% and 30% extract and positive control groups in comparison with the untreated control group. Periodic acid-Schiff and hematoxylin/eosin staining displayed similar results. Conclusion: The n-BuOH fraction of G. siphonantha demonstrated antidermatophyte efficacy in experimental dermatophytosis.

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“…The primary component of jiangu is Saussureae involucratae Flos, however it also consists of 12 types of natural medicine, listed in Table I. These natural components include Punica granatum L. Semen (7), Meconopsis horridula (8), Gentianae Macrophyllae Radix Flos (9), Tinospora sinensis (10), Caryophylli Flos (11), Amomi Fructus Rotundus and Cassiae Semenv (12) that are known to be potent in promoting blood circulation to remove blood stasis and preventing osteoarthritis. In addition, Cinnamomi Cortex (13), Zingiberis Rhizoma, Carthami Flos (14) and Polygonati Rhizoma (15) are components of jiangu with anti-inflammatory and analgesic effects.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the acute and chronic toxicity of the jiangu capsules

et al. 2017

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Abstract. Saussureae involucratae Flos is the primary component of the jiangu capsule, which also consists of 12 types of natural medicine. It is a traditional Chinese medicine used to treat a number of conditions including arthralgia, cold and sore muscles, stiff limbs, inconvenient flexion and activity limitation caused by different types of osteoarthritis. The present study was performed to assess the safety of the jiangu capsule following acute and chronic administration in mice and rats. In the acute study, mice were treated with the jiangu capsule orally at 16 g/kg/day, the highest dose, for 14 days. In the chronic oral toxicity study, rats were treated with 2, 4 and 8 g/kg/day of the jiangu capsule for 6 months. The general condition, body weight changes, food and water consumption, hematological and biochemical parameters, urinalysis, systematic anatomy and organ weights of the rats were monitored and histopathological examination was performed at the end of 3 and 6 months' daily administration, and following 14 days of withdrawal. There were no signs of toxicity in the general condition and body weight of the mice was not significantly affected by the treatment. Furthermore, necropsy findings for the animals in the acute and chronic toxicity studies demonstrated that no mortalities had occurred. The results of the current study indicate that treatment with the jiangu capsule did not induce mortality or any detectable abnormalities in mice and rats.

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Inhibitory effects of the Gentiana macrophylla (Gentianaceae) extract on rheumatoid arthritis of rats

Cited by 69 publications

References 5 publications

<i>Gentiana macrophylla</i> Pall (Gentianaceae) extract exerts protective effects against osteoporosis in mice

<i>Gentiana macrophylla</i> Pall (Gentianaceae) extract exerts protective effects against osteoporosis in mice

Antidermatophyte Activity of the Gentiopicroside-Rich n-Butanol Fraction from <b><i>Gentiana siphonantha</i></b> Maxim. Root on a Guinea Pig Model of Dermatophytosis

Evaluation of the acute and chronic toxicity of the jiangu capsules

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