Selective Inhibition of Cough and Bronchoconstriction in Conscious Guinea Pigs

Forsberg, K.; Karlsson, J.‐A.; Zackrisson, C.; Persson, C. G. A.

doi:10.1159/000196030

Cited by 28 publications

(21 citation statements)

References 13 publications

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“…SATOH et al [8], found that, in the guinea-pig, SR 48968 inhibited the bronchoconstriction induced by citric acid in doses similar to those that we had observed for the inhibition of cough. Dissociation between cough and bronchoconstriction has clearly been demonstrated by FORSBERG et al [27] who, in agreement with FULLER and COLLIER [28] and JACKSON [29], showed that sodium cromoglycate inhibited bronchoconstriction but not citric acid-induced cough, whereas lidocaine inhibited cough but not bronchoconstriction. In this paper, we have shown that salbutamol exerted an antitussive effect in doses of 1-3 mg·kg -1 , i.e.…”

Section: Discussionsupporting

confidence: 67%

Effect of the two tachykinin antagonists, SR 48968 and SR 140333, on cough induced by citric acid in the unanaesthetized guinea pig

Girard¹,

Naline²,

Vilain³

et al. 1995

Eur Respir J

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E Ef ff fe ec ct t o of f t th he e t tw wo o t ta ac ch hy yk ki in ni in n a an nt ta ag go on ni is st ts s, , S SRIn conclusion, our results demonstrate that NK 2 -receptor stimulation plays a predominant role in the regulation of cough reflex, at least in the guinea-pig, as shown by the high potency and efficacy of SR 48968, a tachykinin NK 2 -receptor antagonist. SR 140333, a NK 1 -receptor antagonist is unable to inhibit cough by itself, but it potentiates SR 48968 in terms of efficiency. Finally, as salbutamol did not modify the effect of SR 48968, it may be suggested that the antitussive effect of SR 48968 is not related to the inhibition of citric acid-induced bronchoconstriction.

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Section: Discussionsupporting

confidence: 67%

Effect of the two tachykinin antagonists, SR 48968 and SR 140333, on cough induced by citric acid in the unanaesthetized guinea pig

Girard¹,

Naline²,

Vilain³

et al. 1995

Eur Respir J

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“…Many studies on the effects of local anesthesia in the airway suggest that the airway nervous receptors are primarily associated with the occurrence of cough in human [8], rabbits [12] and asthmatic subjects [27,29]. In this study, aerosolized lidocaine inhibited the citric acid-induced cough in the two strains of guinea pigs; the number of coughs showed a 94.1% decrease in BHS, and a 100% decrease in BHR.…”

Section: Discussionmentioning

confidence: 52%

“…It is a powerful defensive reflex which is Mechanical, chemical and electrical stimuli have been used to elicit cough and discussed with regard to the site and the mechanisms of action in the airway [4,18]. Among them aerosol of citric acid is a potent tussive agent in humans and guinea pigs [13,19] and cough induced by citric acid is accompanied by bronchoconstriction [8,9,16] and sensory neuropeptide release from the perfused lung [21,26]. The citric acid-induced cough was enhanced by cigarette smoke exposure [14], but was suppressed by treatment with ruthenium red aerosol which can block the effects of capsaicin [20].…”

Section: Introductionmentioning

confidence: 99%

The Difference in Citric Acid-Induced Cough in Congenitally Bronchial-Hypersensitive (BHS) and Bronchial-Hyposensitive (BHR) Guinea Pigs.

et al. 2001

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Cough elicitation and major physiological factors influencing cough occurrence were investigated in congenitally bronchial-hypersensitive (BHS) and -hyposensitive (BHR) guinea pigs exposed to citric acid (0.3 M) aerosol for 10 min. The number of cough in BHS was significantly larger than in BHR, while the latency to cough in BHS was significantly shorter than in BHR. Pretreatment with atropine (0.2%), lidocaine (2%) or salbutamol (0.1%) aerosol and desensitization of C-fibers with capsaicin (100 mg/kg) decreased the cough numbers in both BHS and BHR. The salbutamol, atropine and capsaicin pretreatments prolonged the cough latency in BHS, but only salbutamol prolonged the latency in BHR. After salbutamol pretreatment all BHR guinea pigs exhibited cough, while 66.7% of BHS guinea pigs exhibited it. Vagal blocking by atropine suppressed coughing in both BHS and BHR. Only a small number (33.3%) of BHR guinea pigs and no BHR guinea pigs exhibited a cough response after capsaicin and lidocaine pretreatment whereas many BHS guinea pigs still produced cough after such pretreatment. The present study demonstrated that the cough responsiveness to citric acid aerosol was significantly higher in BHS than in BHR. It was revealed that airway smooth muscle contraction and functional and/or morphological development of airway nervous receptors, especially C-fiber endings, contributed to aggravation of coughing in BHS.

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“…Although there is no dispute that mechanical and chemical stimuli applied to the larynx also cause cough, we believe that the reflex responses observed in this study are mainly due to activation of sensors located below the laryngeal level. In facts, a considerable amount of information points at the possibility that, in both animals and humans, the sensory endings mediating laryngeal cough are not promptly activated by agents such as fog and inhaled citric acid (Higenbottam et al, 1989;Forsberg et al, 1990;Stockwell et al, 1993;Tatar et al, 1996;Fontana et al, 1999b). This may be particularly true with threshold concentrations of irritants.…”

Section: Discussionmentioning

confidence: 99%

Cough and ventilatory adjustments evoked by aerosolised capsaicin and distilled water (fog) in man

Lavorini

Pantaleo

Geri

et al. 2007

Respiratory Physiology & Neurobiology

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Airway receptors mediate cough and ventilatory adjustments. Simultaneous assessment of cough sensory-motor components and changes in breathing pattern may provide insights into the receptor(s) prevailingly stimulated by inhaled irritants. Nineteen subjects inhaled capsaicin and fog up to threshold concentrations for cough. Cough intensity, respiratory sensations and changes in breathing pattern induced by the two irritants were compared. Capsaicin and fog cough threshold values did not correlate. Coughing induced by both agents was preceded by qualitatively similar sensations and by significant increases in minute ventilation and respiratory drive due to selective increases in tidal volume (P < 0.01). Cough intensity was similar with both agents. Cough frequency and the intensity of the urge to cough were higher with capsaicin (P < 0.01). The lack of correlation between fog and capsaicin cough threshold values suggests differences in the neural mechanisms activated. The selective increase in tidal volume suggests prevailing involvement of rapidly adapting receptors. The stronger sensations evoked by capsaicin may contribute to the higher cough frequency observed with this agent.

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Selective Inhibition of Cough and Bronchoconstriction in Conscious Guinea Pigs

Cited by 28 publications

References 13 publications

Effect of the two tachykinin antagonists, SR 48968 and SR 140333, on cough induced by citric acid in the unanaesthetized guinea pig

Effect of the two tachykinin antagonists, SR 48968 and SR 140333, on cough induced by citric acid in the unanaesthetized guinea pig

The Difference in Citric Acid-Induced Cough in Congenitally Bronchial-Hypersensitive (BHS) and Bronchial-Hyposensitive (BHR) Guinea Pigs.

Cough and ventilatory adjustments evoked by aerosolised capsaicin and distilled water (fog) in man

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