Selective Inductive Heating of Lymph Nodes

Gilchrist, R. K.; Medal, Richard; Shorey, William D.; Hanselman, Russell C.; Parrott, J. C.; Taylor, C R

doi:10.1097/00000658-195710000-00007

Cited by 924 publications

(514 citation statements)

References 2 publications

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“…The history of the use of magnetic particles for selective heating of tumors started in 1957 when Gilchrist et al used particles of a few mm in size for inductive heating of lymph nodes in dogs [7]. More than 20 years later, Gordon et al used a magnetic fluid ('dextran-magnetites' with a core size of up to 6 nm) for hyperthermia after systemic application [8].…”

Section: Introductionmentioning

confidence: 99%

Clinical applications of magnetic nanoparticles for hyperthermia

Thiesen¹,

Jordan

2008

International Journal of Hyperthermia

719

556

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Magnetic fluids are increasingly used for clinical applications such as drug delivery, magnetic resonance imaging and magnetic fluid hyperthermia. The latter technique that has been developed as a cancer treatment for several decades comprises the injection of magnetic nanoparticles into tumors and their subsequent heating in an alternating magnetic field. Depending on the applied temperature and the duration of heating this treatment either results in direct tumor cell killing or makes the cells more susceptible to concomitant radio-or chemotherapy. Numerous groups are working in this field worldwide, but only one approach has been tested in clinical trials so far. Here, we summarize the clinical data gained in these studies on magnetic fluid induced hyperthermia.

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Section: Introductionmentioning

confidence: 99%

Clinical applications of magnetic nanoparticles for hyperthermia

Thiesen¹,

Jordan

2008

International Journal of Hyperthermia

719

556

View full text Add to dashboard Cite

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“…The technology of magnetic nanoparticle probes, in particular, has seen increased efforts devoted to maturing its potential as a central tool for efficient, cross-application, molecular imaging. Although particles of iron oxide have been used as magnetic contrast agents for over 45 years, 46 refinement in the synthesis and coating of magnetic nanoparticles, especially in the last decade, has led to their employment in an abundance of novel biological applications. These applications include blood pooling, tissue and cell specific contrast agents for magnetic resonance (MR) imaging, cell tracking, and biomolecular detection.…”

Section: Introductionmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

et al. 2006

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Abstract-The field of molecular imaging has recently seen rapid advances in the development of novel contrast agents and the implementation of insightful approaches to monitor biological processes non-invasively. In particular, superparamagnetic iron oxide nanoparticles (SPIO) have demonstrated their utility as an important tool for enhancing magnetic resonance contrast, allowing researchers to monitor not only anatomical changes, but physiological and molecular changes as well. Applications have ranged from detecting inflammatory diseases via the accumulation of non-targeted SPIO in infiltrating macrophages to the specific identification of cell surface markers expressed on tumors. In this article, we attempt to illustrate the broad utility of SPIO in molecular imaging, including some of the recent developments, such as the transformation of SPIO into an activatable probe termed the magnetic relaxation switch.

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“…[694] These substantial shortcomings were eliminated by developing MFH which was first introduced by Gilchrist in 1957 to exploit the inherent capabilities of MNPs for shifting the heating source where it exactly should be, inside the tumor tissue, while preserving the healthy tissues as well. [695] This promising tool revolutionized the existing hyperthermia through enabling localized remote heating of bodily tissue by easily placing MNPs in tumors having pore sizes in 380-780 nm range, [696] either as a stand-alone intervention for magnetic thermoablation or adjunct to chemotherapy and radiotherapy for "moderate" hyperthermia. [687,697] In the case of thermoablation, generated heat rise the temperature between 43 and 55 °C to provoke strong cytotoxic effect causing cells to undergo direct tissue necrosis, coagulation or carbonization.…”

Section: Wwwadvancedsciencenewscom Wwwadvhealthmatdementioning

confidence: 99%

“…In a very especial case, MNPs are combined with thermo-responsive cargos for controlled delivery of drugs. [644b] Gilchrist et al were the first to apply MFH for heat lymph nodes in dogs [695] and made the initial progress to apply it for humans. [702] Since then, numerous animal experiments and studies were carried out to further the potentiate of this technique toward a more practical and safer treating for cancers, especially for the case of gliomas and prostate cancers.…”

Section: Wwwadvancedsciencenewscom Wwwadvhealthmatdementioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

187

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Selective Inductive Heating of Lymph Nodes

Cited by 924 publications

References 2 publications

Clinical applications of magnetic nanoparticles for hyperthermia

Clinical applications of magnetic nanoparticles for hyperthermia

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

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