Selective increase of dopamine D3 receptor gene expression as a common effect of chronic antidepressant treatments

Ch, Lammers; Díaz, Jorge; Jc, Schwartz; Sokoloff, Pierre

doi:10.1038/sj.mp.4000754

Cited by 137 publications

(78 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Also, 4 of these 5 subjects committed suicide, which may have been contributed to by non-compliance, inadequate dosing, and/or treatment refractoriness. Effects of repeated antidepressant treatment on DA receptor mRNAs in the rat brain have been reported, but effects are variable (increase, decrease or no change) depending on the type of antidepressant, the receptor subtype, and the region of brain studied (Ainsworth et al, 1998;Dziedzicka-Wasylewska et al, 1997;Dziedzicka-Wasylewska et al, 2002;Huzarska et al, 2006;Kameda et al, 2000;Lammers et al, 2000). To our knowledge, DA receptor gene expression in the amygdala following antidepressant drug treatment to rats has not been studied.…”

Section: Discussionmentioning

confidence: 93%

Dopamine receptor gene expression in human amygdaloid nuclei: Elevated D4 receptor mRNA in major depression

Xiang

Szebeni

et al. 2008

Brain Research

View full text Add to dashboard Cite

Previous findings from this laboratory demonstrating changes in dopamine (DA) transporter and D2 receptors in the amygdaloid complex of subjects with major depression indicate that disruption of dopamine neurotransmission to the amygdala may contribute to behavioral symptoms associated with depression. Quantitative real-time RT-PCR was used to investigate the regional distribution of gene expression of DA receptors in the human amygdala. In addition, relative levels of mRNA of DA receptors in the basal amygdaloid nucleus were measured postmortem in subjects with major depression and normal control subjects. All five subtypes of DA receptor mRNA were detected in all amygdaloid subnuclei, although D1, D2, and D4 receptor mRNAs were more abundant than D3 and D5 mRNAs by an order of magnitude. The highest level of D1 mRNA was found in the central nucleus, whereas D2 mRNA was the most abundant in the basal nucleus. Levels of D4 mRNA were highest in the basal and central nuclei. In the basal nucleus, amounts of D4, but not D1 or D2, mRNAs were significantly higher in subjects with major depression and depressed suicide victims, as compared to control subjects. These findings demonstrate that the D1, D2 and D4 receptors are the major subtypes of DA receptors in the human amygdala. Elevated DA receptor gene expression in depressive subjects further implicates altered dopaminergic transmission in the amygdala in depression.

show abstract

Section: Discussionmentioning

confidence: 93%

Dopamine receptor gene expression in human amygdaloid nuclei: Elevated D4 receptor mRNA in major depression

Xiang

Szebeni

et al. 2008

Brain Research

View full text Add to dashboard Cite

show abstract

“…Several lines of evidence suggest that dopaminergic actions in the prefrontal cortex may be involved. [2][3][4][5][6][7][8] Catechol-O-methyltransferase (COMT) is a major enzyme in dopamine metabolism in the prefrontal cortex. A common functional polymorphism at codon 158 in the gene coding for COMT (COMT Val158Met) results in substantial effects, with Met (low-activity) allele homozygosity leading to a three-to fourfold reduction in enzymatic activity compared with the Val (highactivity) allele homozygosity.…”

Section: Introductionmentioning

confidence: 99%

Catechol-O-methyltransferase (COMT) polymorphisms predict treatment response in electroconvulsive therapy

Anttila

Huuhka

et al. 2007

Pharmacogenomics J

View full text Add to dashboard Cite

“…Chronic administration of antidepressant drugs is also reported to increase expression of the D 3 receptor in the nucleus accumbens (Lammers et al, 2000). Thus, localized DA deficiency could account for the loss of motivation and anhedonia commonly seen in depressed patients, while an increase in DA function in the mesolimbic system could play a key role in the antidepressant actions of medication (Wilner, 1995).…”

Section: Introductionmentioning

confidence: 99%

Lack of Effect of Tyrosine Depletion on Mood in Recovered Depressed Women

McTavish

Mannie

Harmer

et al. 2005

Neuropsychopharmacol

View full text Add to dashboard Cite

The role of dopamine (DA) pathways in the pathophysiology of depressive disorder is poorly understood. However, because DA plays a key role in motivational behavior, it is important to study in a disorder characterized by anhedonia, lack of energy and psychomotor retardation. A recently developed dietary manipulation ('tyrosine (TYR) depletion') offers a novel method to assess the role of DA in major depression. We studied 15 euthymic women with a past history of recurrent depression, who received a 74 g amino-acid drink lacking TYR and phenylalanine (PHE) (TYR-free) and a balanced (BAL) amino acid drink on two separate occasions in a double-blind, random-order, crossover design. Plasma prolactin levels rose following the TYR-free drink relative to the balanced mixture, while performance on a spatial recognition memory task was impaired. However, relative to the BAL drink, the TYR-free drink did not lower objective or subjective measures of mood. We conclude that as in healthy volunteers, TYR depletion in euthymic subjects, with a past history of major depression, attenuated DA function, as reflected in increased plasma prolactin levels and decreased spatial memory performance. However ratings of depression were unaffected, suggesting that disruption of dopaminergic function by this manipulation does not induce a lowering of mood in individuals vulnerable to depression.

show abstract

Selective increase of dopamine D3 receptor gene expression as a common effect of chronic antidepressant treatments

Cited by 137 publications

References 60 publications

Dopamine receptor gene expression in human amygdaloid nuclei: Elevated D4 receptor mRNA in major depression

Dopamine receptor gene expression in human amygdaloid nuclei: Elevated D4 receptor mRNA in major depression

Catechol-O-methyltransferase (COMT) polymorphisms predict treatment response in electroconvulsive therapy

Lack of Effect of Tyrosine Depletion on Mood in Recovered Depressed Women

Contact Info

Product

Resources

About