Selective IgA deficiency with steatorrhea

Crabbé, P. A.; Heremans, J. F.

doi:10.1016/0002-9343(67)90031-9

Cited by 170 publications

(35 citation statements)

References 34 publications

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“…The marked reduction in IgA-containing cells in the gastric mucosa corresponds with Crabbé and Heremans [11] findings in selective IgA lack. That IgA-containing cells can be demonstrated in the gastric mucosa but not in the bone marrow or peripheral blood, in dicates that the circulating antibody for some reason cannot totally eliminate the cells of the exocrine IgA system.…”

Section: Schmidt Et Al [37] and Miller Et Al [30]supporting

confidence: 83%

Class-Specific Anti-IgA Associated with Severe Anaphylactic Transfusion Reactions in a Patient with Pernicious Anaemia

Bjerrum

Jersild²

1971

Vox Sanguinis

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The case history and investigations of a 32-year-old man with pernicious anaemia and selective absence of IgA in serum and saliva are presented and discussed. On two occasions, the patient, who had not previously been exposed to foreign human serum, developed severe anaphylactic shock after blood transfusion of a few millilitres. A precipitating antibody to IgA was identified in his serum. It was of class-specific type reacting not only with the donors’ sera, but also with other normal sera. The patient had no apparent chromosome abnormality, and no close family members had similar IgA lack. Lymphocyte transformation in vitro with PHA was normal: no stimulation followed exposure to IgA. On fluorescent microscopy, very few IgA-containing cells were seen in the gastric mucosa.

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Section: Schmidt Et Al [37] and Miller Et Al [30]supporting

confidence: 83%

Class-Specific Anti-IgA Associated with Severe Anaphylactic Transfusion Reactions in a Patient with Pernicious Anaemia

Bjerrum

Jersild²

1971

Vox Sanguinis

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“…The significance of the occurrence in JRA of a group with selective IgA (34). IgA deficiency has been reported in children with ataxia telangiectasia (35), in families of patients with hypogammaglobulinemia (36), in systemic lupus erythematosus (37), in steatorrhea (38), and in individuals with recurrent sinopulmonary infections (39,40). IgA deficiency has also been reported in "normal" adult males (41).…”

Section: Methodsmentioning

confidence: 99%

Abnormalities in the Distribution of Serum Immunoglobulin Concentrations in Juvenile Rheumatoid Arthritis

Cassidy¹,

Petty²,

Sullivan³

1973

J. Clin. Invest.

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“…In particular, celiac disease has been reported in association with several primary immunodeficiencies including isolated severe SIgAID [52,53] or reduced IgA levels (20-<60 mg/100 mL) [20,54,55], panhypogammaglobulinemia [53] and isolated combined IgA and IgM deficiency [53]. IgM deficiency has been more frequently reportedincluding 30 of 75 (37%) of adult cases, 5 of 5 childhood cases [20], 11 of 30 (37%) untreated adult patients [54], 8 of 11 untreated adult patients [55], 6 of 11 untreated, and 2 of 7 treated adult patients [55].…”

Section: T Cell Functionsmentioning

confidence: 99%

Pediatric Selective Igm Immunodeficiency

Goldstein

Dunsky

et al. 2008

Chest

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Objective. Limited information exists on features of pediatric Selective IgM immunodeficiency (SIgMID). Previously published pediatric cases and 2 new cases are reviewed. Methods. English literature from PubMed and references from relevant articles were reviewed. Previously reported cases and 2 new cases from an allergy/immunology practice were analyzed. Results. Fortynine reported cases of SIgMID presented with respiratory infections (77.6%), gastrointestinal disease (16.3%), skin disease (12.2%), and meningitis (8.2%). Mean serum IgM level was 16.5 ± 13.8 mg/dL. Two patients were identified with SIgMID among 6300 active pediatric patients (0.03%) presenting with asthma, vasomotor rhinitis, and recurrent respiratory infections. In the 51 cases reported, none developed lymphoproliferative disease nor evolved into panhypogammaglobulinemia; four fatalities were reported. Conclusions. The prevalence of SIgMID in our pediatric population was 0.03%. In general, respiratory infections are the common comorbid conditions. Death and autoimmune disease are uncommon complications of pediatric SIgMID.

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Selective IgA deficiency with steatorrhea

Cited by 170 publications

References 34 publications

Class-Specific Anti-IgA Associated with Severe Anaphylactic Transfusion Reactions in a Patient with Pernicious Anaemia

Class-Specific Anti-IgA Associated with Severe Anaphylactic Transfusion Reactions in a Patient with Pernicious Anaemia

Abnormalities in the Distribution of Serum Immunoglobulin Concentrations in Juvenile Rheumatoid Arthritis

Pediatric Selective Igm Immunodeficiency

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