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Objective. Limited information exists on features of pediatric Selective IgM immunodeficiency (SIgMID). Previously published pediatric cases and 2 new cases are reviewed. Methods. English literature from PubMed and references from relevant articles were reviewed. Previously reported cases and 2 new cases from an allergy/immunology practice were analyzed. Results. Forty-nine reported cases of SIgMID presented with respiratory infections (77.6%), gastrointestinal disease (16.3%), skin disease (12.2%), and meningitis (8.2%). Mean serum IgM level was 16.5 ± 13.8 mg/dL. Two patients were identified with SIgMID among 6300 active pediatric patients (0.03%) presenting with asthma, vasomotor rhinitis, and recurrent respiratory infections. In the 51 cases reported, none developed lymphoproliferative disease nor evolved into panhypogammaglobulinemia; four fatalities were reported. Conclusions. The prevalence of SIgMID in our pediatric population was 0.03%. In general, respiratory infections are the common comorbid conditions. Death and autoimmune disease are uncommon complications of pediatric SIgMID.

Objective. Limited information exists on features of pediatric Selective IgM immunodeficiency (SIgMID). Previously published pediatric cases and 2 new cases are reviewed. Methods. English literature from PubMed and references from relevant articles were reviewed. Previously reported cases and 2 new cases from an allergy/immunology practice were analyzed. Results. Fortynine reported cases of SIgMID presented with respiratory infections (77.6%), gastrointestinal disease (16.3%), skin disease (12.2%), and meningitis (8.2%). Mean serum IgM level was 16.5 ± 13.8 mg/dL. Two patients were identified with SIgMID among 6300 active pediatric patients (0.03%) presenting with asthma, vasomotor rhinitis, and recurrent respiratory infections. In the 51 cases reported, none developed lymphoproliferative disease nor evolved into panhypogammaglobulinemia; four fatalities were reported. Conclusions. The prevalence of SIgMID in our pediatric population was 0.03%. In general, respiratory infections are the common comorbid conditions. Death and autoimmune disease are uncommon complications of pediatric SIgMID.

RATIONALE: Assess the quality of life in patients with chronic urticaria (CU) through the questionnaire -Chronic Urticaria -Quality of Life Questionnaire (CU-Q2oL). METHODS: This cross-sectional study assessed patients with chronic urticaria followed up in a tertiary hospital. The CU-Q2oL contains 23 questions, with scores from 1 (no complaints) to 5 (many complaints). We consider the scores > _ 3 as poor quality of life. They were classified into two groups: A -those patients who respond to antihistaminics (AH1), and B -others medications beyond the AH1. We considered the difference between (B-A) > _ 1 in each question, as relevant. The groups were assessed about the duration of disease > _ 10 years. RESULTS: Sixty-one patients participated in the study, of these, 58 (95%) were female and the mean age was 41 years. The average of the CU-Q2oL score was 72.5 for group B and 57.2 for group A. When we evaluated the time of disease > _ 10 years, group A had 37% comparing to group B, 56%. The difference between groups B and A > _ 1 was observed for the following issues: 3, 15, 17, 19 20, 21. CONCLUSIONS: These results showed that the group with recalcitrant CU (group B) had urticaria for a longer time and a higher score for CU-Q2oL. Among the issues, those that were more important were related to social relationships, diet and side effects of medicines. J ALLERGY CLIN IMMUNOL FEBRUARY 2016 AB258 Abstracts MONDAY