Selective growth inhibition of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans by antisense peptide nucleic acids

Sugimoto, Sadaomi; Maéda, Hiroshi; Kitamatsu, Mizuki; Nishikawa, Ikuo; Shida, Muneyasu

doi:10.1016/j.mcp.2018.11.006

Cited by 6 publications

(1 citation statement)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, anti- acpP PNA exhibited no marked growth-inhibitory effect on these species. Thus, anti- groEL PNA-peptides appear to constitute potential species-specific antibacterial tools against oral pathogens 67 .…”

Section: Biopharmaceuticals; Antisense Peptide Nucleic Acid Antibioticsmentioning

confidence: 99%

Selected strategies to fight pathogenic bacteria

Plotniece

Sobolev

Supuran

et al. 2023

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

Natural products and analogues are a source of antibacterial drug discovery. Considering drug resistance levels emerging for antibiotics, identification of bacterial metalloenzymes and the synthesis of selective inhibitors are interesting for antibacterial agent development. Peptide nucleic acids are attractive antisense and antigene agents representing a novel strategy to target pathogens due to their unique mechanism of action. Antisense inhibition and development of antisense peptide nucleic acids is a new approach to antibacterial agents. Due to the increased resistance of biofilms to antibiotics, alternative therapeutic options are necessary. To develop antimicrobial strategies, optimised in vitro and in vivo models are needed. In vivo models to study biofilm-related respiratory infections, device-related infections: ventilator-associated pneumonia, tissue-related infections: chronic infection models based on alginate or agar beads, methods to battle biofilm-related infections are discussed. Drug delivery in case of antibacterials often is a serious issue therefore this review includes overview of drug delivery nanosystems.

show abstract

Section: Biopharmaceuticals; Antisense Peptide Nucleic Acid Antibioticsmentioning

confidence: 99%