Selected strategies to fight pathogenic bacteria

Plotniece, Aiva; Sobolev, Arkadij; Supuran, Claudiu T.; Carta, Fabrizio; Björkling, Fredrik; Franzyk, Henrik; Yli‐Kauhaluoma, Jari; Augustyns, Koen; Cos, Paul; Vooght, Linda De; Govaerts, Matthias; Aizawa, Juliana; Tammela, Päivi; Žalubovskis, Raivis

doi:10.1080/14756366.2022.2155816

Cited by 29 publications

(17 citation statements)

References 326 publications

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“…This issue was solved by converting CuNPs to CuONPs, which have higher stability but slightly lower activity 56 . The antibacterial activity of CuONPs has not been well understood, but it is assumed to involve in bacterial cell wall adhesion stimulated by electrostatic interactions 57 . Dissociation of Cu 2+ can induce the production of reactive oxygen species (ROS) that could damage the cellular membranes.…”

Section: Resultsmentioning

confidence: 99%

Green synthesized AgNPs, CuONPs, and Ag‐CuO NCs to effective antibiofilm activities and their potential application in aquaculture

Manikandan,

Arumugam,

Abdul

et al. 2023

Applied Organom Chemis

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The expanded emergence of drug‐resistant microbes remains a concern to the scientific community in developing effective therapeutics. Approach of green chemistry based nanomaterials fabrication is in high demand, due to biocompatibility, non‐toxic, and high surface area that adheres more biomolecules on surface. Green fabricated silver nanoparticles (AgNPs), copper oxide nanoparticles (CuONPs), and silver–copper oxide nanocomposites (Ag‐CuO NCs) were characterized by fluorescence and Raman spectroscopy, field emission scanning electron microscopy (FE‐SEM) with energy‐dispersive X‐ray spectroscopy (EDX), and thermogravimetric (TG)/differential scanning calorimetry (DSC) analysis. Antibiofilm potential of green fabricated AgNPs, CuONPs, and Ag‐CuO NCs was tested against aquatic pathogenic microorganisms such as Aeromonas hydrophila, Pseudomonas aeruginosa, and Staphylococcus aureus. This present study deals with bacterial growth rate, biofilm inhibition, and antibiofilm architecture of AgNPs, CuONPs, and Ag‐CuO NCs under the visualization of confocal laser scanning electron microscopy (CLSM). The FE‐SEM technique was used to observe dense and compact structure (control without NPs treatment) with treatment of NPs that showed reduced amount of cell population in A. hydrophila, P. aeruginosa, and S. aureus. The effective antibiofilm inhibition of Ag‐CuO NCs was achieved by reducing micro‐colonies compared with AgNPs and CuONPs. The AgNPs, CuONPs, and Ag‐CuO NCs demonstrated antibiofilm properties against Gram‐negative and Gram‐positive bacteria, indicating a combinatorial effect of green fabricated NPs in combination with plant metabolites against pathogenic bacteria. As a result, aforementioned nano‐product merits further investigation in order to be used as a potent adjuvant therapy as antagonistic toward various bacterial diseases in aquaculture.

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Section: Resultsmentioning

confidence: 99%

Green synthesized AgNPs, CuONPs, and Ag‐CuO NCs to effective antibiofilm activities and their potential application in aquaculture

Manikandan,

Arumugam,

Abdul

et al. 2023

Applied Organom Chemis

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“…Yield 46%. 1 (32). Compound 32 was obtained according to the general procedure earlier reported using 4isothiocyanatobenzenesulfonamide 21.…”

Section: 0]heptane-2-carboxylic Acid (31)mentioning

confidence: 99%

Development of Penicillin-Based Carbonic Anhydrase Inhibitors Targeting Multidrug-Resistant Neisseria gonorrhoeae

Bonardi,

Nocentini,

Giovannuzzi

et al. 2024

J. Med. Chem.

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The development of antibacterial drugs with new mechanisms of action is crucial in combating the rise of antibiotic-resistant infections. Bacterial carbonic anhydrases (CAs, EC 4.2.1.1) have been validated as promising antibacterial targets against pathogens such as Helicobacter pylori, Neisseria gonorrhoeae, and vancomycin-resistant enterococci. A multitarget strategy is proposed to design penicillin-based CA inhibitor hybrids for tackling resistance by targeting multiple bacterial pathways, thereby resensitizing drug-resistant strains to clinical antibiotics. The sulfonamide derivatives potently inhibited the CAs from N. gonorrhoeae and Escherichia coli with K I values in the range of 7.1–617.2 nM. Computational simulations with the main penicillin-binding protein (PBP) of N. gonorrhoeae indicated that these hybrid derivatives maintained the mechanism of action of the lead β-lactams. A subset of derivatives showed potent PBP-related antigonococcal effects against multidrug-resistant N. gonorrhoeae strains, with several compounds significantly outperforming both the lead β-lactam and CA inhibitor drugs (MIC values in the range 0.25 to 0.5 μg/mL).

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“…Targeting bacterial enzymes is not a new approach, but identifying compounds that target metalloenzymes, especially carbonic anhydrase inhibitors (CAIs), has been intensively studied in the last ten years. For example, the bacteriostatic effect of CAIs was demonstrated for Helicobacter pylori , Escherichia coli and Mycobacterium tuberculosis [ 170 ]. In addition, CAI sulfonamides such as acetazolamide [ 171 ], its derivatives [ 172 ] and dorzolamide [ 173 ] have recently been shown to be effective against vancomycin-resistant Enterococcus (VRE).…”

Section: Drugs As Antibiotic Alternatives or Complementsmentioning

confidence: 99%

Resistance, Tolerance, Virulence and Bacterial Pathogen Fitness—Current State and Envisioned Solutions for the Near Future

2023

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The current antibiotic crisis and the global phenomena of bacterial resistance, inherited and non-inherited, and tolerance—associated with biofilm formation—are prompting dire predictions of a post-antibiotic era in the near future. These predictions refer to increases in morbidity and mortality rates as a consequence of infections with multidrug-resistant or pandrug-resistant microbial strains. In this context, we aimed to highlight the current status of the antibiotic resistance phenomenon and the significance of bacterial virulence properties/fitness for human health and to review the main strategies alternative or complementary to antibiotic therapy, some of them being already clinically applied or in clinical trials, others only foreseen and in the research phase.

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Selected strategies to fight pathogenic bacteria

Cited by 29 publications

References 326 publications

Green synthesized AgNPs, CuONPs, and Ag‐CuO NCs to effective antibiofilm activities and their potential application in aquaculture

Green synthesized AgNPs, CuONPs, and Ag‐CuO NCs to effective antibiofilm activities and their potential application in aquaculture

Development of Penicillin-Based Carbonic Anhydrase Inhibitors Targeting Multidrug-Resistant Neisseria gonorrhoeae

Resistance, Tolerance, Virulence and Bacterial Pathogen Fitness—Current State and Envisioned Solutions for the Near Future

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