Selective extraction of lamivudine in human serum and urine using molecularly imprinted polymer technique

Shekarchi, Mohammad; Pourfarzib, Mojgan; Akbari‐adergani, Behrouz; Mehramizi, Ali; Javanbakht, Mehran; Dinarvand, Rassoul

doi:10.1016/j.jchromb.2013.04.041

Cited by 33 publications

(15 citation statements)

References 30 publications

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“…The results of incubating the polymers in a 1.0x10 −4 M VCV solution prepared in pure H 2 O are shown in Table . The results show that using MAA as a functional monomer led to higher binding capacities when compared to 4‐VP, which could be attributed to the stronger hydrophobic and electrostatic interactions between MAA and VCV in a polar environment .…”

Section: Resultsmentioning

confidence: 99%

Voltammetric Determination of Valaciclovir Using a Molecularly Imprinted Polymer Modified Carbon Paste Electrode

et al. 2017

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A molecularly imprinted polymer (MIP) was rationally synthesized with the aid of computer based studies. The computational studies were used to screen for the most suitable template to functional monomer molar ratio. Two functional monomers were involved in the study (methacrylic acid and 4‐vinylpyridine). Four MIP ratios were synthesized in accordance with the results of the computational studies and their performance was evaluated using equilibrium rebinding assays. The MIP with the best performance was used as an additive in carbon paste electrodes for the voltammetric determination of valaciclovir (VCV). Following the optimization of voltammetric parameters, a linear response was obtained in the range of 1.0x10−6–7.0x10−4 M with a limit of detection at 4.45x10−7 M. The MIP modified carbon paste electrode was successfully applied for the determination of VCV in pure solutions and dosage form.

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Section: Resultsmentioning

confidence: 99%

Voltammetric Determination of Valaciclovir Using a Molecularly Imprinted Polymer Modified Carbon Paste Electrode

et al. 2017

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“…Alternative methodologies can be used to generate MIPs using traditional bulk polymerization [135], sol-gel [136], precipitation polymerization [137], or suspension polymerization [138], (Fig. 4).…”

Section: Molecularly-imprinted Polymers (Mips)mentioning

confidence: 99%

“…MIPs have demonstrated promising applications in several areas {e.g., chemical/biological sensors [142], chromatographic stationary phases [143], chiral separation [152], antibody mimics [146], catalysts [147], and drugdelivery systems [148]}. MIPs have many applications in sample-preparation techniques as exemplified in several studies [135,158].…”

Section: Molecularly-imprinted Polymers (Mips)mentioning

confidence: 99%

Recent advances and future trends in new materials for sample preparation

Fumes

Silva

Andrade

et al. 2015

TrAC Trends in Analytical Chemistry

175

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“…In our previously published papers, the technique of molecular imprinting has been applied with success to the preparation of high affinity SPE for bromhexine [22], metoclopramide [23], tramadol [24], dextromethorphan [25], penicillin G [26], carbamazepine [27], dipyridamole [28], lamivudine [29], and efavirenz [30]. Herein we present a simple and straightforward method for the performance evaluation of adefovir based MIPs as selective sorbents for efficient sample clean-up and further determination of adefovir from biological matrices by HPLC.…”

Section: Introductionmentioning

confidence: 99%

Water‐compatible molecularly imprinted polymer as a sorbent for the selective extraction and purification of adefovir from human serum and urine

Pourfarzib

Dinarvand

Akbari‐adergani

et al. 2015

J of Separation Science

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A molecularly imprinted polymer has been synthesized to specifically extract adefovir, an antiviral drug, from serum and urine by dispersive solid-phase extraction before high-performance liquid chromatography with UV analysis. The imprinted polymers were prepared by bulk polymerization by a noncovalent imprinting method that involved the use of adefovir (template molecule) and functional monomer (methacrylic acid) complex prior to polymerization, ethylene glycol dimethacrylate as cross-linker, and chloroform as porogen. Molecular recognition properties, binding capacity, and selectivity of the molecularly imprinted polymers were evaluated and the results show that the obtained polymers have high specific retention and enrichment for adefovir in aqueous medium. The new imprinted polymer was utilized as a molecular sorbent for the separation of adefovir from human serum and urine. The serum and urine extraction of adefovir by the molecularly imprinted polymer followed by high-performance liquid chromatography showed a linear calibration curve in the range of 20-100 μg/L with excellent precisions (2.5 and 2.8% for 50 μg/L), respectively. The limit of detection and limit of quantization were determined in serum (7.62 and 15.1 μg/L), and urine (5.45 and 16 μg/L). The recoveries for serum and urine samples were found to be 88.2-93.5 and 84.3-90.2%, respectively.

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Selective extraction of lamivudine in human serum and urine using molecularly imprinted polymer technique

Cited by 33 publications

References 30 publications

Voltammetric Determination of Valaciclovir Using a Molecularly Imprinted Polymer Modified Carbon Paste Electrode

Voltammetric Determination of Valaciclovir Using a Molecularly Imprinted Polymer Modified Carbon Paste Electrode

Recent advances and future trends in new materials for sample preparation

Water‐compatible molecularly imprinted polymer as a sorbent for the selective extraction and purification of adefovir from human serum and urine

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