Selective extraction of clonazepam from human plasma and urine samples by molecularly imprinted polymeric beads

Panahi, Homayon Ahmad; Mehramizi, Ali; Ghassemi, Somayeh

doi:10.1002/jssc.201301144

Cited by 16 publications

(14 citation statements)

References 26 publications

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“…The values of k ′ of the MIP NPs for tartrazine and carmine were 9.766 and 12.64, indicating that the MIP NPs exhibited specific recognition ability for SY. It was perfectly match with SY size and shape of the cavity in the MIP NPs .…”

Section: Resultssupporting

confidence: 66%

Synthesis of molecularly imprinted polymer nanoparticles for the fast and highly selective adsorption of sunset yellow

et al. 2016

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Novel molecularly imprinted polymer nanoparticles were synthesized by precipitation polymerization with sunset yellow as the template and [2-(methacryloyloxy)ethyl] trimethylammonium chloride as the functional monomer. The molecularly imprinted polymer nanoparticles were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, and their specific surface area and thermal stability were measured. The molecularly imprinted polymer nanoparticles had a high adsorption capacity in wide pH range (pH 1-8) for sunset yellow. The adsorption equilibrium only needed 5 min, and the quantitative desorption was very fast (1 min) by using 10.0 mol/L HCl as the eluant. The maximum adsorption capacity of the molecularly imprinted polymer nanoparticles for sunset yellow was 144.6 mg/g. The adsorption isotherm and kinetic were well consistent with Langmuir adsorption model and pseudo-second-order kinetic model, respectively. The relative selectivity coefficients of the molecularly imprinted polymer nanoparticles for tartrazine and carmine were 9.766 and 12.64, respectively. The prepared molecularly imprinted polymer nanoparticles were repeatedly used and regenerated ten times without significant absorption capacity decrease.

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Section: Resultssupporting

confidence: 66%

Synthesis of molecularly imprinted polymer nanoparticles for the fast and highly selective adsorption of sunset yellow

et al. 2016

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“…Recently, molecularly imprinted polymers (MIPs) have received considerable attention in the field of separation, adsorption, sensors, catalysis, targeted drug delivery, medicine analysis, and SPE . They have been used for the sensitive and selective determination, and effective enrichment of samples.…”

Section: Introductionmentioning

confidence: 99%

Preparation and application of magnetic molecularly imprinted polymers for the isolation of chelerythrine from Macleaya cordata

Zhong

Wang

et al. 2018

J of Separation Science

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A novel type of magnetic molecularly imprinted polymer was prepared for the selective enrichment and isolation of chelerythrine from Macleaya cordata (Willd) R. Br. The magnetic molecularly imprinted polymers were prepared using functional Fe O @SiO as a magnetic support, chelerythrine as template, methacrylic acid as functional monomer, and ethylene glycol dimethacrylate as cross-linker. Density functional theory at the B3LYP/6-31G (d, p) level with Gaussian 09 software was applied to calculate the interaction energies of chelerythrine, methacrylic acid and the complexes formed from chelerythrine and methacrylic acid in different ratios. The structural features and morphology of the synthesized polymers were characterized by using Fourier transform infrared spectroscopy, X-ray diffraction, transmission electron microscopy, and vibration sample magnetometry. Adsorption experiments revealed that the magnetic molecularly imprinted polymers possessed rapid kinetics, high selectivity, and a higher binding capacity (7.96 mg/g) to chelerythrine than magnetic molecularly non-imprinted polymers (2.36 mg/g). The adsorption process was in good agreement with the Langmuir adsorption isotherm and pseudo-second-order kinetics models. Furthermore, the magnetic molecularly imprinted polymers were successfully employed as adsorbents for the extraction and enrichment of chelerythrine from Macleaya cordata (Willd) R. Br. The results indicated that the magnetic molecularly imprinted polymers were suitable for the selective adsorption of chelerythrine from complex samples such as natural medical plants.

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“…Because of their inherent properties including robustness, multiple usage, lifetime, and selectivity, molecularly imprinted polymers (MIPs) have been applied as stationery phases in column chromatography , recognition elements in sensors , bioassays , and adsorbents in SPE, so called molecularly imprinted solid‐phase extraction (MISPE) . However, despite such successful reports, several drawbacks such as heterogeneity of the binding sites, low average binding affinities, incompatibility with aqueous media, and template leaching have limited a more widespread application as antibody mimics.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of stationary phases that provide group recognition for polychlorinated biphenyls by porogenic fragment template imprinting

Ndunda

Mizaikoff

2016

J of Separation Science

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Molecular recognition based on imprinted polymers results from the polymerization of functional monomers and cross-linkers in the presence of a target analyte (i.e. template), with subsequent removal of the template to create synthetic binding sites. However, complete removal of the template is difficult to achieve, thereby leading to template leaching, which adversely affects real-world analytical applications. To overcome this challenge, the present study utilizes porogenic fragment template imprinting techniques to provide an alternative synthetic strategy to generate molecularly imprinted polymers with molecular recognition toward polychlorinated biphenyls. Thereafter, thus-generated imprinted polymers have been applied as stationary phases in molecularly imprinted solid-phase extraction for preconcentrating six "indicator polychlorinated biphenyls" in both organic and aqueous media. Recoveries of up to 98.9% (imprinted polymers) versus 73.0% (conventional C18 ) in an organic phase, and up to 97.4% (imprinted polymers) versus 89.4% (C18 ) in an aqueous phase have been achieved corroborating the utility of this advanced sorbent material. Finally, porogenic fragment template imprinting strategies have yielded molecularly imprinted polymers that are useful for the quantitative determination of polychlorinated biphenyls in environmental matrices, which provides a low-cost strategy for tailoring stationary phases that avoid template leaching in applications in solid-phase extraction as well as liquid chromatography.

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Selective extraction of clonazepam from human plasma and urine samples by molecularly imprinted polymeric beads

Cited by 16 publications

References 26 publications

Synthesis of molecularly imprinted polymer nanoparticles for the fast and highly selective adsorption of sunset yellow

Synthesis of molecularly imprinted polymer nanoparticles for the fast and highly selective adsorption of sunset yellow

Preparation and application of magnetic molecularly imprinted polymers for the isolation of chelerythrine from Macleaya cordata

Synthesis of stationary phases that provide group recognition for polychlorinated biphenyls by porogenic fragment template imprinting

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