2014
DOI: 10.1002/jssc.201301144
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Selective extraction of clonazepam from human plasma and urine samples by molecularly imprinted polymeric beads

Abstract: A molecularly imprinted polymer (MIP) based on free-radical polymerization was prepared with 1-(N,N-biscarboxymethyl)amino-3-allylglycerol and N,N-dimethylacrylamide as functional monomers, N,N-methylene diacrylamide as the cross-linker, copper ion-clonazepam as the template and 2,2-azobis(2-methylbutyronitrile) as the initiator. The imprinted polymer was characterized by Fourier transform infrared spectroscopy, elemental analysis, thermo-gravimetric analysis, and SEM. The MIP of agglomerated microparticles wi… Show more

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Cited by 16 publications
(14 citation statements)
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“…The values of k ′ of the MIP NPs for tartrazine and carmine were 9.766 and 12.64, indicating that the MIP NPs exhibited specific recognition ability for SY. It was perfectly match with SY size and shape of the cavity in the MIP NPs .…”
Section: Resultssupporting
confidence: 66%
“…The values of k ′ of the MIP NPs for tartrazine and carmine were 9.766 and 12.64, indicating that the MIP NPs exhibited specific recognition ability for SY. It was perfectly match with SY size and shape of the cavity in the MIP NPs .…”
Section: Resultssupporting
confidence: 66%
“…Recently, molecularly imprinted polymers (MIPs) have received considerable attention in the field of separation, adsorption, sensors, catalysis, targeted drug delivery, medicine analysis, and SPE . They have been used for the sensitive and selective determination, and effective enrichment of samples.…”
Section: Introductionmentioning
confidence: 99%
“…Because of their inherent properties including robustness, multiple usage, lifetime, and selectivity, molecularly imprinted polymers (MIPs) have been applied as stationery phases in column chromatography , recognition elements in sensors , bioassays , and adsorbents in SPE, so called molecularly imprinted solid‐phase extraction (MISPE) . However, despite such successful reports, several drawbacks such as heterogeneity of the binding sites, low average binding affinities, incompatibility with aqueous media, and template leaching have limited a more widespread application as antibody mimics.…”
Section: Introductionmentioning
confidence: 99%