Selective detection of pyrophosphate anion by zinc ensemble of C3-symmetric triaminoguanidine-pyrrole conjugate and its biosensing applications

A fluorescence based dual sensor for Zn2+ and PO43− and the application of soft computing methods to predict machine learning outcomes

“…Selective detection of phosphate anions is necessary for both chemists and biologists, 31,32 as they serve a crucial role in gene regulation, genetic information storage, energy transduction, nerve signal processing, kidney function, and muscle contraction. 33–35 Derivatives of phosphate (PO 4 3− ) create various products through DNA and RNA polymerization events, ATP hydrolysis in cells, and other biological activities.…”

“…The mechanisms followed by these sensors include photoinduced energy transfer (PET), 26 chelation enhanced fluorescence (CHEF), 27 fluorescence resonance energy transfer (FRET), 28 metal to ligand charge transfer (MLCT) 29 and CQN isomerization. 30 Selective detection of phosphate anions is necessary for both chemists and biologists, 31,32 as they serve a crucial role in gene regulation, genetic information storage, energy transduction, nerve signal processing, kidney function, and muscle contraction. [33][34][35] Derivatives of phosphate (PO 4 3À ) create various products through DNA and RNA polymerization events, ATP hydrolysis in cells, and other biological activities.…”

“…42 For this reason, selective detection of the phosphate ion is necessary. Several articles were published on the sensing of phosphate (PO 4 3À ) anions, [31][32][33][34][35][36][37][38][39][40][41][42][43] but the simultaneous detection of Zn 2+ and PO 4 3À using a single probe is not much reported in the literature.…”

Heavy metal‐free electrochemical detection of pyrophosphate ions by Nafion/carbon dots decorated screen printed carbon electrodes

“…[5][6][7] On the other hand, the PPi content in synovial fluid is used to monitor chondrocalcinosis, calcium pyrophosphate deposition disease, arthritis, urolithiasis, etc. [8][9][10][11][12][13] Research suggest that high levels of extracellular PPi might lead to problems with bone mineralization since they can inhibit hydroxyapatite formation, leading to hypophosphatasia, [14,15] while some reports also link PPi to the clotting of blood vessels. [16] Therefore, developing an effective receptor system for selective PPi detection is very important for the early-stage detection of these diseases.…”

An AIE active acidochromic pyrimidine-functionalized two-in-one fluorescent probe for selective relay detection of Al3+/Zn2+ and PPi with various detection applications

“…26 Sensing trace amounts of some biologically important anions like pyrophosphate (PPi) has been highlighted owing to the key role they play in biological processes along with DNA sequencing. 27,28 With respect to the specific cation-anion interactions, detection of pyrophosphates using metal complexes has been implemented as a unique strategy. 29 Nevertheless, developing a fluorescencebased chemosensor for PPi is still considered as a formidable task by analytical researchers while scrutinizing certain factors, like physiological and compatible conditions and due to the high selectivity over other biologically important anions (ATP, AMP and some nucleotides).…”