Selective detection of magnetic nanoparticles in biomedical applications using differential magnetometry

Visscher, M.; Waanders, Sebastiaan; Krooshoop, Hendrikus J.G.; Haken, Bennie ten

doi:10.1016/j.jmmm.2014.04.044

Cited by 20 publications

(14 citation statements)

References 34 publications

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“…The higher sensitivity for the 59 nm tracer is due to differences in magnetic properties of the tracers, arising from differences in size and material of the magnetic cores. 26 By injecting the magnetic tracer 24 hours before surgery, one may be able to improve the iron uptake by the SLNs and thereby improve the performance of a tracer. However, extending the period between injection and surgery could allow adverse SPIO migration to higher echelon nodes beyond the SLN.…”

mentioning

confidence: 99%

Comparison of three magnetic nanoparticle tracers for sentinel lymph node biopsy in an in vivo porcine model

Pouw¹,

Ahmed²,

Anninga³

et al. 2015

IJN

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Introduction Breast cancer staging with sentinel lymph node biopsy relies on the use of radioisotopes, which limits the availability of the procedure worldwide. The use of a magnetic nanoparticle tracer and a handheld magnetometer provides a radiation-free alternative, which was recently evaluated in two clinical trials. The hydrodynamic particle size of the used magnetic tracer differs substantially from the radioisotope tracer and could therefore benefit from optimization. The aim of this study was to assess the performance of three different-sized magnetic nanoparticle tracers for sentinel lymph node biopsy within an in vivo porcine model. Materials and methods Sentinel lymph node biopsy was performed within a validated porcine model using three magnetic nanoparticle tracers, approved for use in humans (ferumoxytol, with hydrodynamic diameter d H =32 nm; Sienna+ ® , d H =59 nm; and ferumoxide, d H =111 nm), and a handheld magnetometer. Magnetometer counts (transcutaneous and ex vivo), iron quantification (vibrating sample magnetometry), and histopathological assessments were performed on all ex vivo nodes. Results Transcutaneous “hotspots” were present in 12/12 cases within 30 minutes of injection for the 59 nm tracer, compared to 7/12 for the 32 nm tracer and 8/12 for the 111 nm tracer, at the same time point. Ex vivo magnetometer counts were significantly greater for the 59 nm tracer than for the other tracers. Significantly more nodes per basin were excised for the 32 nm tracer compared to other tracers, indicating poor retention of the 32 nm tracer. Using the 59 nm tracer resulted in a significantly higher iron accumulation compared to the 32 nm tracer. Conclusion The 59 nm tracer demonstrated rapid lymphatic uptake, retention in the first nodes reached, and accumulation in high concentration, making it the most suitable tracer for intraoperative sentinel lymph node localization.

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mentioning

confidence: 99%

Comparison of three magnetic nanoparticle tracers for sentinel lymph node biopsy in an in vivo porcine model

Pouw¹,

Ahmed²,

Anninga³

et al. 2015

IJN

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“…As we know, many factors, such as particles diameter, magnetization intensity and liftoff, will directly affect the intensity of the stray magnetic field. For example, the magnetic moment of a spherical MNP is proportional to the 3rd power of its diameter [10]. As a comparison, the diameter of MNPs used in literature [7] is 184 ± 4.5 nm and a stray magnetic field with an intensity of 0.19 Oe is observed by GMR sensors.…”

Section: Resultsmentioning

confidence: 99%

“…To overcome the disadvantages, inductive techniques [8,9,10,11,12] and magnetic sensors, such as giant magnetoresistance (GMR) [7,13,14,15,16,17] sensors and anisotropic magnetoresistance (AMR) sensors [18] have been used to successfully quantify the nanoparticles by measuring the magnetic response of MNPs.…”

Section: Introductionmentioning

confidence: 99%

Contactless Measurement of Magnetic Nanoparticles on Lateral Flow Strips Using Tunneling Magnetoresistance (TMR) Sensors in Differential Configuration

Lei

Wang

et al. 2016

Sensors

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Magnetic nanoparticles (MNPs) are commonly used in biomedical detection due to their capability to bind with some specific antibodies. Quantification of biological entities could be realized by measuring the magnetic response of MNPs after the binding process. This paper presents a contactless scanning prototype based on tunneling magnetoresistance (TMR) sensors for quantification of MNPs present in lateral flow strips (LFSs). The sensing unit of the prototype composes of two active TMR elements, which are parallel and closely arranged to form a differential sensing configuration in a perpendicular magnetic field. Geometrical parameters of the configuration are optimized according to theoretical analysis of the stray magnetic field produced by the test line (T-line) while strips being scanned. A brief description of our prototype and the sample preparation is presented. Experimental results show that the prototype exhibits the performance of high sensitivity and strong anti-interference ability. Meanwhile, the detection speed has been improved compared with existing similar techniques. The proposed prototype demonstrates a good sensitivity for detecting samples containing human chorionic gonadotropin (hCG) at a concentration of 25 mIU/mL. The T-line produced by the sample with low concentration is almost beyond the visual limit and produces a maximum stray magnetic field some 0.247 mOe at the sensor in the x direction.

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“…Other magnetic probes that are based on the fundamental mode of orthogonal fluxgate (FM-OFG) [ 50 , 51 , 52 , 53 ], such as a magnetic tunneling junction (MTJ) sensor [ 54 ] and negatively charged nitrogen-vacancy centers in diamonds, have been developed. DiffMag is based on a pickup coil with AC and DC differential magnetometry [ 55 , 56 ]. These magnetic probes have demonstrated the ability to detect between 280 ng and 500 µg SPIONs from a distance of 1 mm to 2.5 cm.…”

Section: Intraoperative Diagnosis During Surgerymentioning

confidence: 99%

Application of Magnetic Nanoparticles for Rapid Detection and In Situ Diagnosis in Clinical Oncology

Onishi

Mihara

Matsuda

et al. 2022

Cancers

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Screening, monitoring, and diagnosis are critical in oncology treatment. However, there are limitations with the current clinical methods, notably the time, cost, and special facilities required for radioisotope-based methods. An alternative approach, which uses magnetic beads, offers faster analyses with safer materials over a wide range of oncological applications. Magnetic beads have been used to detect extracellular vesicles (EVs) in the serum of pancreatic cancer patients with statistically different EV levels in preoperative, postoperative, and negative control samples. By incorporating fluorescence, magnetic beads have been used to quantitatively measure prostate-specific antigen (PSA), a prostate cancer biomarker, which is sensitive enough even at levels found in healthy patients. Immunostaining has also been incorporated with magnetic beads and compared with conventional immunohistochemical methods to detect lesions; the results suggest that immunostained magnetic beads could be used for pathological diagnosis during surgery. Furthermore, magnetic nanoparticles, such as superparamagnetic iron oxide nanoparticles (SPIONs), can detect sentinel lymph nodes in breast cancer in a clinical setting, as well as those in gallbladder cancer in animal models, in a surgery-applicable timeframe. Ultimately, recent research into the applications of magnetic beads in oncology suggests that the screening, monitoring, and diagnosis of cancers could be improved and made more accessible through the adoption of this technology.

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Selective detection of magnetic nanoparticles in biomedical applications using differential magnetometry

Cited by 20 publications

References 34 publications

Comparison of three magnetic nanoparticle tracers for sentinel lymph node biopsy in an in vivo porcine model

Comparison of three magnetic nanoparticle tracers for sentinel lymph node biopsy in an in vivo porcine model

Contactless Measurement of Magnetic Nanoparticles on Lateral Flow Strips Using Tunneling Magnetoresistance (TMR) Sensors in Differential Configuration

Application of Magnetic Nanoparticles for Rapid Detection and In Situ Diagnosis in Clinical Oncology

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Selective detection of magnetic nanoparticles in biomedical applications using differential magnetometry

Cited by 20 publications

References 34 publications

Comparison of three magnetic nanoparticle tracers for sentinel lymph node biopsy in an in&nbsp;vivo porcine model

Comparison of three magnetic nanoparticle tracers for sentinel lymph node biopsy in an in&nbsp;vivo porcine model

Contactless Measurement of Magnetic Nanoparticles on Lateral Flow Strips Using Tunneling Magnetoresistance (TMR) Sensors in Differential Configuration

Application of Magnetic Nanoparticles for Rapid Detection and In Situ Diagnosis in Clinical Oncology

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Comparison of three magnetic nanoparticle tracers for sentinel lymph node biopsy in an in vivo porcine model

Comparison of three magnetic nanoparticle tracers for sentinel lymph node biopsy in an in vivo porcine model