Selective deficit of angiogenic growth factors characterises pregnancies complicated by pre‐eclampsia

Reuvekamp, Alida; Velsing-Aarts, Francien V.; Poulina, Indira E. J.; Capello, Jaques J.; Duits, Ashley J.

doi:10.1111/j.1471-0528.1999.tb08107.x

Cited by 179 publications

(92 citation statements)

References 34 publications

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“…On the other hand, our results are contradictory to several studies [12][13][14], which demonstrated significant decrease of serum VEGF levels in preeclampsia. Levine et al [25] reported that the antiangiogenic protein, total soluble fms-like tyrosine kinase 1 (sFlt-1), is significantly elevated in serum of women with preeclampsia.…”

Section: Discussioncontrasting

confidence: 99%

“…Maternal and fetal circulating angiogenin levels did not differ significantly in pregnancies with small-for-gestational age and appropriate-forgestational age infants [17]. Only two studies have shown that serum angiogenin concentration did not change significantly in preeclampsia when compared to that of controls [13,18].…”

Section: Introductionmentioning

confidence: 88%

“…The role of VEGF serum levels in pregnancy and preeclampsia, however, has been discussed controversially. Several studies have shown that VEGF concentrations are increased in the plasma or serum of women with preeclampsia [6][7][8][9][10][11], while others revealed decreased concentrations [12][13][14]. On the other hand Hefler et al [15] reported no significant difference of serum VEGF levels between women with preeclampsia and healthy pregnant women.…”

Section: Introductionmentioning

confidence: 94%

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Angiogenin and vascular endothelial growth factor in pregnancies complicated by preeclampsia

Shaarawy

Al-Sokkary

Sheba

et al. 2004

Intl J Gynecology & Obste

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 94%

See 1 more Smart Citation

Angiogenin and vascular endothelial growth factor in pregnancies complicated by preeclampsia

Shaarawy

Al-Sokkary

Sheba

et al. 2004

Intl J Gynecology & Obste

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“…However, although the properties of VEGF have rapidly led to its investigation as a potential pathophysiological molecule in preeclampsia, there has been considerable controversy over the levels of circulating VEGF during the last 10 years (Baker et al 1995;Bates et al 2006;Sharkey et al 1996). A large number of studies have shown that free available VEGF levels are significantly reduced in preeclampsia (Bates et al 2006;Livingston et al 2000;Reuvekamp et al 1999). Therefore, although the total levels of VEGF may be increased in this disorder, the physiologically active concentration may actually be reduced (Bates et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Distribution of Notch protein members in normal and preeclampsia-complicated placentas

et al. 2007

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Notch proteins are a transmembrane receptor family that is structurally and functionally conserved from worms to humans. The mammalian family of Notch proteins consists of several genes encoding Notch receptors and related Notch ligands. Notch signaling is involved in different aspects of the cell-fate decision tree: differentiation, proliferation, and apoptosis. These three processes are finely regulated in human placenta in order to allow a successful pregnancy and correct fetal growth. Notch and its ligands also participate in vascular remodeling and stabilization. Vasculogenesis and blood regulation are of importance in the human placenta for normal fetal development and growth; any disorder of these systems leads to preeclampsia. Drawing on this background, we have investigated the expression of Notch-1, Notch-4, and Jagged-1, together with two members related to the Notch pathway in angiogenesis: VEGF and p21. Normal and preeclamptic human placentas have been evaluated by immunohistochemistry. In preeclamptic samples, a down-regulation of Notch pathway members occurs with a weak/moderate expression of the Notch protein members in all components of placenta compared with physiological placentas that, at term, exhibit the strong expression of Jagged-1 and a moderate expression of both Notch-1 and Notch-4 in all compartments of the placental villi. Moreover, preeclamptic samples also reveal a down-regulation of VEGF expression, together with a moderate nuclear expression of p21(Cip1) in the syncytiotrophoblast, cytotrophoblast, and endothelial cells. This down-regulation of VEGF in preeclamptic placentas, in turn, probably decreases Notch protein expression in placental compartments and in endothelial cells and could offer an ethiopathogenetic explanation for the onset of this pathology.

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“…# Corresponding author, E-mail: qiao_fuyuan@126.com growth factor (VEGF), which plays a critical role in the embryogenesis and the tumor angiogenesis, was found to express in both placenta tissue and blood serum of preeclampsia patients [4] . Recent studies showed that VEGF expression in preeclampsia pregnancies was abnormal [5,6] . On the basis of these pieces of evidence, we speculated that the endothelium damage in preeclampsia was associated with aberrant VEGF expression.…”

mentioning

confidence: 98%

VEGF deficit is involved in endothelium dysfunction in preeclampsia

Zhou

Liu

Qiao

et al. 2010

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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This study examined the association of expression of vascular endothelial growth factor (VEGF), a promoter of angiogenesis, with endothelium dysfunction in preeclampsia. The level of VEGF protein and mRNA in the placenta and peripheral blood samples of 30 preeclampsia patients and 30 normotensive pregnant women was measured by immunohistochemistry, real-time reverse transcriptase-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA), respectively. VEGF expression in the human umbilical vein endothelial cells (HUVECs) was blocked by small interfering RNAs (siRNAs). The monolayer barrier function of HUVECs was determined by measuring the fluorescence intensity of BSA that crossed the HUVEC monolayers. The cell proliferation and cell-secreted nitric oxide (NO) level were detected by MTT method and nitrate reductase assay, respectively. The results showed that VEGF was expressed in the syncytiotrophoblasts and endothelial cells of vessels and capillaries in the placenta tissue. The serum level of VEGF in the preeclampsia patients was significantly decreased as compared with that in normal pregnant subjects, although VEGF mRNA expression in the placenta tissue of preeclampsia patients remained still high. Moreover, VEGF deficit could lead to endothelium cell dysfunction, and the administration of VEGF could protect endothelium cells from injury. It was concluded that lack of VEGF contributes to endothelium dysfunction, which may lead to the occurrence and development of preeclampsia.

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Selective deficit of angiogenic growth factors characterises pregnancies complicated by pre‐eclampsia

Cited by 179 publications

References 34 publications

Angiogenin and vascular endothelial growth factor in pregnancies complicated by preeclampsia

Angiogenin and vascular endothelial growth factor in pregnancies complicated by preeclampsia

Distribution of Notch protein members in normal and preeclampsia-complicated placentas

VEGF deficit is involved in endothelium dysfunction in preeclampsia

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