Selective cytotoxicity of indirect nonequilibrium atmospheric pressure plasma against ovarian clear-cell carcinoma

Utsumi, Fumi; Kajiyama, Hiroaki; Nakamura, Kae; Tanaka, Hiromasa; Hori, Masaru; Kikkawa, Fumitaka

doi:10.1186/2193-1801-3-398

Cited by 102 publications

(67 citation statements)

References 28 publications

(46 reference statements)

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“…Cold plasma affects biological targets not only directly but also indirectly through the medium, which has broadened the potential applications of non-thermal atmospheric pressure plasma in medicine41424344454647484950. We have demonstrated that plasma-irradiated medium, also called plasma-activated medium (PAM), has anti-tumor effects against glioblastoma5152, as well as ovarian5354, gastric55, pancreatic56, and lung cancer cells57. Plasma interacts with oxygen, nitrogen, and water in air to produce various radicals, such as hydroxyl radicals and nitric oxide.…”

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confidence: 99%

Non-thermal atmospheric pressure plasma activates lactate in Ringer’s solution for anti-tumor effects

Tanaka

Nakamura

Mizuno

et al. 2016

Sci Rep

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178

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Non-thermal atmospheric pressure plasma is a novel approach for wound healing, blood coagulation, and cancer therapy. A recent discovery in the field of plasma medicine is that non-thermal atmospheric pressure plasma not only directly but also indirectly affects cells via plasma-treated liquids. This discovery has led to the use of non-thermal atmospheric pressure plasma as a novel chemotherapy. We refer to these plasma-treated liquids as plasma-activated liquids. We chose Ringer’s solutions to produce plasma-activated liquids for clinical applications. In vitro and in vivo experiments demonstrated that plasma-activated Ringer’s lactate solution has anti-tumor effects, but of the four components in Ringer’s lactate solution, only lactate exhibited anti-tumor effects through activation by non-thermal plasma. Nuclear magnetic resonance analyses indicate that plasma irradiation generates acetyl and pyruvic acid-like groups in Ringer’s lactate solution. Overall, these results suggest that plasma-activated Ringer’s lactate solution is promising for chemotherapy.

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confidence: 99%

Non-thermal atmospheric pressure plasma activates lactate in Ringer’s solution for anti-tumor effects

Tanaka

Nakamura

Mizuno

et al. 2016

Sci Rep

Self Cite

178

166

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“…Further work indicated the selective PAM treatment of ovarian clear cell carcinoma, which is particularly unaffected by conventional chemotherapies. 99 …”

Section: App Applicationsmentioning

confidence: 99%

Aqueous Plasma Pharmacy: Preparation Methods, Chemistry, and Therapeutic Applications

et al. 2016

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Plasma pharmacy is a subset of the broader field of plasma medicine. Although not strictly defined, the term aqueous plasma pharmacy (APP) is used to refer to the generation and distribution of reactive plasma-generated species in an aqueous solution followed by subsequent administration for therapeutic benefits. APP attempts to harness the therapeutic effects of plasma-generated oxidant species within aqueous solution in various applications, such as disinfectant solutions, cell proliferation related to wound healing, and cancer treatment. The subsequent use of plasma-generated solutions in the APP approach facilitates the delivery of reactive plasma species to internal locations within the body. Although significant efforts in the field of plasma medicine have concentrated on employing direct plasma plume exposure to cells or tissues, here we focus specifically on plasma discharge in aqueous solution to render the solution biologically active for subsequent application. Methods of plasma discharge in solution are reviewed, along with aqueous plasma chemistry and the applications for APP. The future of the field also is discussed regarding necessary research efforts that will enable commercialization for clinical deployment.

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“…], as well as to biological and medical effects of plasma-activated cell growth media. [274][275][276][277][278][279][280]…”

Section: O Concept Of Plasma Pharmacology: Plasma-activated Water (Pmentioning

confidence: 99%

Review of Major Directions in Non-Equilibrium Atmospheric Plasma Treatments in Medical, Biological, and Bioengineering Applications

Han

2013

Plasma Med

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Plasma Medicine is the newest and rapidly expanding area of engineering medicine and bioengineering focused on direct applications of plasma for treatment of different diseases, blood coagulation control, wound management, and wound healing, as well as improving patient care through sterilization, medical implants, biomaterial engineering, and tissue engineering. The number of medical engineering professionals, researchers, upper undergraduate, and graduate university students involved today in plasma medicine is already large and growing; there is also an exponentially growing number of publications in this new field. All these students and professionals need the ability to find these publications to aid them in getting started and to advance in their research in plasma medicine. This determines the main purpose of this review, focused on, first of all, summarizing the major directions of fundamental plasma medicine and providing an extensive guide to specific diseases with current plasma-bioengineering solutions, as well as providing a relevant, up-to-date bibliography.

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Selective cytotoxicity of indirect nonequilibrium atmospheric pressure plasma against ovarian clear-cell carcinoma

Cited by 102 publications

References 28 publications

Non-thermal atmospheric pressure plasma activates lactate in Ringer’s solution for anti-tumor effects

Non-thermal atmospheric pressure plasma activates lactate in Ringer’s solution for anti-tumor effects

Aqueous Plasma Pharmacy: Preparation Methods, Chemistry, and Therapeutic Applications

Review of Major Directions in Non-Equilibrium Atmospheric Plasma Treatments in Medical, Biological, and Bioengineering Applications

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