Selective contrast‐enhanced computed tomography is appropriate in diffuse large B‐cell lymphoma therapy response assessment

Kriegsmann, Katharina; Wack, Maurizio; Kriegsmann, Mark; Cremer, Martin; Brückner, Thomas; Ho, Anthony D.; Wuchter, Patrick; Witzens‐Harig, Mathias

doi:10.1111/ejh.13150

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…Furthermore, the size of lymph nodes does not appear to be a mandatory indicator of disease involvement . 18 F‐FDG PET was not performed routinely in our cohort, and consequently, it was only possible to re‐evaluate CT images . The reason why we did not include PET data or only patients with PET results was to avoid a selection bias, since younger patients were more often candidates for PET.…”

Section: Discussionmentioning

confidence: 99%

“…25,26 18 F-FDG PET was not performed routinely in our cohort, and consequently, it was only possible to re-evaluate CT images. 27 The reason why we did not include PET data or only patients with PET results was to avoid a selection bias, since younger patients were more often candidates for PET. Today, the national guidelines for high-grade B-cell lymphoma state that PET-CT should be done, although this is not always performed.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic impact of abdominal lymph node involvement in diffuse large B‐cell lymphoma

Abdulla

Guglielmo

Hollander

et al. 2019

European J of Haematology

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Objective The prognostic value of site of nodal involvement in diffuse large B‐cell lymphomas (DLBCL) is mainly unknown. We aimed to determine the prognostic significance of nodal abdominal involvement in relation to tumour cell markers and clinical characteristics of 249 DLBCL patients in a retrospective single‐centre study. Methods Contrast‐enhanced computed tomography (CT) of the abdomen and thorax revealed pathologically enlarged abdominal lymph nodes in 156 patients, while in 93 patients there were no pathologically enlarged lymph nodes in the abdomen. In 81 cases, the diagnosis of DLBCL was verified by histopathological biopsy obtained from abdominal lymph node. Results Patients with abdominal nodal disease had inferior lymphoma‐specific survival (P = .04) and presented with higher age‐adjusted IPI (P < .001), lactate dehydrogenase (P < .001) and more often advanced stage (P < .001), bulky disease (P < .001), B symptoms (P < .001), and double expression of MYC and BCL2 (P = .02) compared to patients without nodal abdominal involvement, but less often extranodal involvement (P < .02). The worst outcome was observed in those where the abdominal nodal involvement was verified by histopathological biopsy. Conclusion Diffuse large B‐cell lymphomas patients with abdominal nodal disease had inferior outcome and more aggressive behaviour, reflected both in clinical and biological characteristics.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prognostic impact of abdominal lymph node involvement in diffuse large B‐cell lymphoma

Abdulla

Guglielmo

Hollander

et al. 2019

European J of Haematology

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Patients With Malignant Lymphoma and HIV Infection Experiencing Remission After First-Line Treatment Have an Excellent Prognosis

Kriegsmann

Klee

Hensel

et al. 2019

Clinical Lymphoma Myeloma and Leukemia

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Selective contrast‐enhanced computed tomography is appropriate in diffuse large B‐cell lymphoma therapy response assessment

Abstract: Our retrospective analysis provides a rationale for selective imaging of initially involved DLBCL sites for therapy response assessment.

Cited by 2 publications

References 22 publications

Prognostic impact of abdominal lymph node involvement in diffuse large B‐cell lymphoma

Prognostic impact of abdominal lymph node involvement in diffuse large B‐cell lymphoma

Patients With Malignant Lymphoma and HIV Infection Experiencing Remission After First-Line Treatment Have an Excellent Prognosis

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