Selective chemical modification of silicon nitride/silicon oxide nanostructures to develop label-free biosensors

Bañuls, María‐José; González-Pedro, Victoria; Barrios, Carlos Angulo; Puchades, Rosa; Maquieira, Ángel

doi:10.1016/j.bios.2009.10.048

Cited by 49 publications

(32 citation statements)

References 27 publications

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“…A careful design including optimisations of material parameters (refractive indices, scattering losses), structure and prism material will bring substantial improvements in future works. A possible surface functionalisation providing selectivity towards aggregates [26] is also compatible.…”

Section: Discussionmentioning

confidence: 87%

Detection of protein aggregation with a Bloch surface wave based sensor

Paeder

Musi

Hvozdara

et al. 2011

Sensors and Actuators B: Chemical

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Section: Discussionmentioning

confidence: 87%

Detection of protein aggregation with a Bloch surface wave based sensor

Paeder

Musi

Hvozdara

et al. 2011

Sensors and Actuators B: Chemical

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“…Using this structure, the center layer, inside of holes, is chemically different than the membrane outer surface. In a biosensing application, surface chemistry can hence be used to functionalize the inside of holes to capture target particles, while the membrane outer surface can be passivated [34]. In this way, target particles tend to stick at positions with maximum optical field intensity, ensuring maximal sensitivity.…”

Section: Simulations Of Perfectly Periodic Photonic Crystal Membranesmentioning

confidence: 99%

Photonic-crystal membranes for optical detection of single nano-particles, designed for biosensor application

Grepstad¹,

Kaspar²,

Solgaard³

et al. 2012

Opt. Express

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Abstract:A sensor designed to detect bio-molecules is presented. The sensor exploits a planar 2D photonic crystal (PC) membrane with sub-micron thickness and through holes, to induce high optical fields that allow detection of nano-particles smaller than the diffraction limit of an optical microscope. We report on our design and fabrication of a PC membrane with a nano-particle trapped inside. We have also designed and built an imaging system where an optical microscope and a CCD camera are used to take images of the PC membrane. Results show how the trapped nano-particle appears as a bright spot in the image. In a first experimental realization of the imaging system, single particles with a radius of 75 nm can be detected.

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“…Overall, the coupling schemes that are commonly utilized are based on physical (electrostatic adsorption), chemical (covalent bond formation), and biological (high affinity biological moieties) approaches. Although these examples will not be discussed in detail in this paper, many review articles in the literature can provide a good overview of the different protein immobilization methods [26,27,28,29,30,31,32]. …”

Section: Biosensorsmentioning

confidence: 99%

Emerging Cytokine Biosensors with Optical Detection Modalities and Nanomaterial-Enabled Signal Enhancement

Singh

Truong

Reeves

et al. 2017

Sensors

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Protein biomarkers, especially cytokines, play a pivotal role in the diagnosis and treatment of a wide spectrum of diseases. Therefore, a critical need for advanced cytokine sensors has been rapidly growing and will continue to expand to promote clinical testing, new biomarker development, and disease studies. In particular, sensors employing transduction principles of various optical modalities have emerged as the most common means of detection. In typical cytokine assays which are based on the binding affinities between the analytes of cytokines and their specific antibodies, optical schemes represent the most widely used mechanisms, with some serving as the gold standard against which all existing and new sensors are benchmarked. With recent advancements in nanoscience and nanotechnology, many of the recently emerging technologies for cytokine detection exploit various forms of nanomaterials for improved sensing capabilities. Nanomaterials have been demonstrated to exhibit exceptional optical properties unique to their reduced dimensionality. Novel sensing approaches based on the newly identified properties of nanomaterials have shown drastically improved performances in both the qualitative and quantitative analyses of cytokines. This article brings together the fundamentals in the literature that are central to different optical modalities developed for cytokine detection. Recent advancements in the applications of novel technologies are also discussed in terms of those that enable highly sensitive and multiplexed cytokine quantification spanning a wide dynamic range. For each highlighted optical technique, its current detection capabilities as well as associated challenges are discussed. Lastly, an outlook for nanomaterial-based cytokine sensors is provided from the perspective of optimizing the technologies for sensitivity and multiplexity as well as promoting widespread adaptations of the emerging optical techniques by lowering high thresholds currently present in the new approaches.

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Selective chemical modification of silicon nitride/silicon oxide nanostructures to develop label-free biosensors

Cited by 49 publications

References 27 publications

Detection of protein aggregation with a Bloch surface wave based sensor

Detection of protein aggregation with a Bloch surface wave based sensor

Photonic-crystal membranes for optical detection of single nano-particles, designed for biosensor application

Emerging Cytokine Biosensors with Optical Detection Modalities and Nanomaterial-Enabled Signal Enhancement

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