Selective Capture of Thallium and Cesium by a Cryptophane Soluble at Neutral pH

Abstract

We report in this article the synthesis of an asymmetrical cryptophane derivative (possessing only C3-symmetry) bearing three phenol groups and three other carboxylic acid functions, each of these groups on the aromatic rings. Thanks to isothermal

Synthesis of Cryptophanes: Recent Advances

“…[52] The group also studied the selective capture of Tl + and Cs + ions by 52 in aqueous solution (Scheme 7a, route A and B). [53] In the latter study, the synthetic pathway of route B generated the imploded form of the cryptophane in significant amount, which does not have any efficient binding properties. In another study by Brotin et al the syn-isomer 48 underwent hydrogenolysis in 83 % yield and 53 was used to study the binding properties with Cs + and Tl + ions (Scheme 7b).…”

Radiochemistry: A Hot Field with Opportunities for Cool Chemistry

“…Host−guest chemistry developed for K (I) and transmembrane proteins evolved to bind K (I) preferentially could further inform effective bifunctional chelator design. 83,84 Challenges in incorporating 223 Ra into bifunctional, targeted systems using selective and inert chelation have parallels to Tl-201. 223 Ra is to date the only alpha emitting radioisotope that has reached FDA approval and finds wide-ranging application in clinical settings.…”

“…Divergence of Tl (I) from K (I) chemistry is predominantly observed due to the relativistically contracted valence shell, the low electrical charge, and a stereoactive lone pair. Host–guest chemistry developed for K (I) and transmembrane proteins evolved to bind K (I) preferentially could further inform effective bifunctional chelator design. , …”

Synthesis and Physicochemical Properties of Cryptophazane—A Soluble and Functionalizable C1‐Symmetrical Cryptophane

“…Cryptophanes are cage-like host molecules and composed of two cyclotriveratrylene (CTV) units usually connected by alkylene-dioxy linkers (Figure 1). [1,2] These molecular hosts are able to encapsulate many different entities including small molecules, [3] metal cations, [4][5][6][7] or gases such as radon [8] or methane. [4,5,9,10] In particular, a huge interest has emerged for cryptophanes as they are particularly well suited to the encapsulation of xenon.…”