Radiochemistry: A Hot Field with Opportunities for Cool Chemistry

Abstract

Recent Food and Drug Administration (FDA) approval of diagnostic and therapeutic radiopharmaceuticals and concurrent miniaturization of particle accelerators leading to improved access has fueled interest in the development of chemical transformations suitable for short-lived radioactive isotopes on the tracer scale. This recent renaissance of radiochemistry is paired with new opportunities to study fundamental chemical behavior and reactivity of elements to improve their production, separation, and incorporation into bioactive molecules to generate new radiopharmaceuticals. This outlook outlines pertinent challenges in the field of radiochemistry and indicates areas of opportunity for chemical discovery and development, including those of clinically established (C-11, F-18) and experimental radionuclides in preclinical development across the periodic table.

Polymeric Nanoparticles Containing Ruthenium Complexes for Biomedical Applications: A Mini-Review on Recent Developments

“…This treatment also induces several side effects such as gastrointestinal symptoms, hepatotoxicity, hematological anomalies (thrombocytopenia and leukopenia), or dermatological reactions (rash and pruritis). Radiopharmaceuticals based on metals have become essential tools in nuclear medicines: technetium-99m or gallium-68 are used on a daily basis worldwide for diagnostic imaging . Metalloantibiotics have also recently emerged as promising candidates in order to overcome antibiotic resistance …”

Chiroptical Properties of a Cryptophane Soluble at Neutral pH

“…The ability of host molecules to encapsulate thallium cation could lead to new organic interesting chelators for delivering 201 Tl to specific tissues. [9] Our previous work revealed that the presence of hydroxyl functions was mandatory to sequester these two species, and that complexation efficiency increased with the number of hydroxyl functions. [6c-e] Moreover, increasing the size of the cavity decreased the complexation efficiency.…”

Improving the In Vivo Stability of [52Mn]Mn(II) Complexes with 18-Membered Macrocyclic Chelators for PET Imaging

“…Another interesting property of manganese complexes is the possibility of developing redox-responsive systems, taking advantage of the Mn­(II)/Mn­(III) pair . This strategy has been investigated for Mn-based MRI contrast agents, exploiting changes in 1 H relaxation enhancement effects upon varying the oxidation state of the metal ion. , Though application to radiochemistry could be more difficult, the development of the radiochemistry of redox-responsive Mn­(II)-based pharmaceuticals could pose an interesting challenge . Therefore, studying the electrochemistry of Mn­(II) complexes is an important assay to assess the properties of these systems.…”

“… 22 , 23 Though application to radiochemistry could be more difficult, the development of the radiochemistry of redox-responsive Mn(II)-based pharmaceuticals could pose an interesting challenge. 21 Therefore, studying the electrochemistry of Mn(II) complexes is an important assay to assess the properties of these systems.…”