Selective Bilirubin Removal by Plasma Treatment With Plasorba BR-350 for Early Cholestatic Graft Dysfunction

Adani, Gian Luigi; Lorenzin, Dario; Currò, Giuseppe; Sainz-Barriga, Mauricio; Comuzzi, C.; Bresàdola, Vittorio; Avellini, Claudio; Baccarani, Umberto

doi:10.1016/j.transproceed.2007.05.010

Cited by 17 publications

(9 citation statements)

References 5 publications

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“…Furthermore, the PSAF system performs all of these functions in a single-filter unit. Target molecules are captured physically and chemically by adsorbents [15]; as a result, no supplementary plasma supply is necessary. After plasma adsorption, conventional hemofiltration is used to regulate hydration levels and remove water-soluble substances.…”

Section: Discussionmentioning

confidence: 99%

Development of a Multifunctional Detoxifying Unit for Liver Failure Patients

Lee¹,

Mun²,

Min³

2012

Blood Purif

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Background/Aims: Extracorporeal blood detoxification strategies aimed at supporting impaired liver function have been explored because of the imbalance between donor organs and waiting patients. A limited number of artificial devices are now available clinically, and these are characterized by the use of multistage adsorption procedures in conjunction with hemodialysis, but these features simultaneously increase system complexity and treatment costs. Methods: The authors developed a simpler strategy for liver dialysis based on the use of a multifunctional filter, which enables plasma separation and perfusion in a single unit. Results: Liver dialysis treatments were successfully performed using the devised unit when bovine blood containing uremic and hepatic toxins was circulated. Removal of the solutes under investigation was significant, and reduction ratios of 78% for urea, 98% for creatinine and 91% for bilirubin were achieved. Plasma free hemoglobin levels were reasonably maintained despite prolonged blood recirculation for 5 h, and platelet, hematocrit and hemoglobin levels remained uniform throughout liver dialysis sessions. Conclusion: The devised liver support unit may offer a straightforward and efficient means of cleansing blood for patients with hepatic failure.

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Section: Discussionmentioning

confidence: 99%

Development of a Multifunctional Detoxifying Unit for Liver Failure Patients

Lee¹,

Mun²,

Min³

2012

Blood Purif

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“…-Плазмосорбция и плазмофильтрация эффективно снижают уровень билирубина и других токсических метаболитов, образующихся на фоне механической желтухи и холестаза [112][113][114][115]. Уровень достоверности (доказательности) В. Уровень убедительности рекомендации IIa.…”

Section: заместительная печеночная терапияunclassified

“…Adani и соавт. [112] использовали ПС на основе сорбента Plasorda BR-350 у пациентов с холестазом после трансплантации печени. Проведено по три сеанса у каждого больного с объемом обработанной плазмы 7500 мл.…”

Section: заместительная печеночная терапияunclassified

Perioperative management of patients with concomitant liver diseases

Zabolotskikh¹,

Громова²,

Lebedinsky³

et al. 2018

Anesteziologiya I Reanimatologiya

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Громова Елена Георгиевна-д-р мед. наук, проф., заведующая ОРИТ №2 ФГБУ Российский онкологический научный центр им. Н.Н. Блохина РАМН, Москва, Россия Лебединский Константин Михайлович-д-р мед. наук, проф., заведующий кафедрой анестезиологии и реаниматологии им. В.Л. Ваневского ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России, Президент общероссийской общественной организации «Федерация анестезиологов и реаниматологов», Санкт-Петербург, Россия Лубнин Андрей Юрьевич-д-р мед. наук, проф., зав. отделением анестезиологии и реанимации ФГАУ «Национальный научнопрактический центр нейрохирургии им. акад. Н.Н. Бурденко» Минздрава России, председатель Московского научного общества анестезиологов-реаниматологов, Москва, Россия Осовских Виктор Васильевич-канд. мед. наук, руководитель научной группы анестезиологии и реаниматологии ФГБУ «РНЦРХТ им. акад. А.М. Гранова» Минздрава России, Санкт-Петербург, Россия Хорошилов Сергей Евгеньевич-д-р мед. наук, заслуженный врач РФ, начальник отделения гемодиализа, Главный военный клинический госпиталь им. акад. Н.Н. Бурденко, Москва, Россия Щеголев Алексей Валерианович-д-р мед. наук, доцент, заслуженный врач РФ, начальник кафедры анестезиологии и реаниматологии ФГБВОУ ВПО «Военно-медицинская академия им. С.М. Кирова» МО РФ, главный анестезиолог-реаниматолог МО РФ, главный внештатный анестезиолог-реаниматолог Комитета по здравоохранению Администрации Санкт-Петербурга, председатель Санкт-Петербургского научно-практического общества анестезиологов и реаниматологов, член Президиума ФАР,

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“…However, these existing adsorbents was found to have limited unspecific absorptive capacity and poor biocompatibility. For example, plasma perfusion with ion exchange resins (e.g., BS330 from Jafron, China, and BR350 from Asahi Kasei Medical, Japan) was applied for the treatment of hyperbilirubinemia through a strong electrostatic force between negatively charged bilirubin and the high density of quaternary ammonium group ( Adani et al, 2007 ; Meijers et al, 2007 ). However, strong anion exchange resins show dissatisfactory hemocompatibility, and a large dose of injected heparin leads to the increasing cost and the risk of clinical treatment.…”

Section: Introductionmentioning

confidence: 99%

Multi-Functional Hypercrosslinked Polystyrene as High-Performance Adsorbents for Artificial Liver Blood Purification

Liu

Peng

2022

Front. Chem.

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In artificial liver blood purification system, highly efficient removal of multiple toxic metabolites from whole blood by hemoperfusion still remains a challenge in the clinical field, due to the limited unspecific absorptive capacity and low biocompatibility of adsorbents. In this work, a new pyridinyl-modified hypercrosslinked polystyrene (HCP) adsorbent, named HCP(St-DVB-VP), was constructed directly through a Friedel-Crafts post-crosslinking reaction using a small-molecule crosslinking agent for the first time. The preparation method provides in this study can avert the problem posed by the use of the toxic carcinogenic chloromethyl ether reagent in the traditional HCP resin synthesis process. The results indicated that HCP(St-DVB-VP) had a highly porous structure with a specific surface area of 761 m2 g−1. Notably, the adsorbent demonstrated excellent adsorptive properties towards both protein-bound toxins (bilirubin) and medium- and large-sized molecular toxins (PTH, IL-6) in vitro experiments simultaneously. More importantly, the obtained adsorbent showed acceptable hemocompatibility. Taken together, the low-cost and ecofriendly fabrication method, broad-spectrum adsorption performance and hemocompatibility makes the HCP(St-DVB-VP) promising for whole blood perfusion in artificial liver blood purification in clinical practice.

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Selective Bilirubin Removal by Plasma Treatment With Plasorba BR-350 for Early Cholestatic Graft Dysfunction

Cited by 17 publications

References 5 publications

Development of a Multifunctional Detoxifying Unit for Liver Failure Patients

Development of a Multifunctional Detoxifying Unit for Liver Failure Patients

Perioperative management of patients with concomitant liver diseases

Multi-Functional Hypercrosslinked Polystyrene as High-Performance Adsorbents for Artificial Liver Blood Purification

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