We
report the synthesis and characterization of two water-soluble
container compounds (cavitand hosts) with rigidified open ends. One
cavitand uses four (CH2)4’s as spacers
to bridge the adjacent walls, while another cavitand uses four CH2CH2OCH2CH2’s bridges
and features a wider open end. The spacers preorganize the deep cavitands
into vase-like, receptive shapes and prevent their unfolding to the
unreceptive kite-like conformation. Cycloalkane guests (C6–C8)
and small n-alkanes (C5–C7) form 1:1 complexes
with the cavitands and move freely in the cavitands’ spaces.
Hydrophilic compounds 1,4-dioxane, tetrahydrofuran, tetrahydropyran,
pyridine, and 1-methylimidazole also showed good binding affinity
to the new cavitands. Longer alkanes (C11–C14) and n-alcohols (C11–C16) are taken up with a −CH3 group fixed at the bottom of the cavity and the groups near
the rim in compressed conformations. The methylene bridges appear
to divide the cavitand into a narrow hydrophobic compartment and a
broader space with exposure to the aqueous medium. Longer alkane guests
(C15–C18), N,N-dimethyldioctylammonium,
and dioctylamine induce the formation of capsules (2:1 host:guest
complexes). The new cavitands showed selectivity for p/m-cresol isomers and xylene isomers. The cavitand
with CH2CH2OCH2CH2 bridges
bound long-chain α,ω-diols (C13–C15) and diamines
in folded, U-shaped conformations with polar functions exposed to
the aqueous medium. It was used to separate o-xylene
from its isomers by using simple extraction procedures.