Selective Adsorption of Homocysteine Using HFR-on Line Technique

Splendiani, G; Cortese, Claudio; Angelis, Sandro De; Tullio, T.; Dessı̀, Mariarita; Pastore, Anna; Casciani, Stefania; Ruggia, R

doi:10.1097/00002480-200303000-00201

Cited by 4 publications

(4 citation statements)

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“…2. The following approaches were investigated in the included works: haemodialysis (HD) [21, 22, 31–65]; haemofiltration (HF) [66, 67]; dilution techniques, membranes or haemofiltrate‐reinfusion (HFR) in haemodiafiltration (HDF) [68–83]; continuous ambulatory peritoneal dialysis (CAPD) [84–87]; effects of various adsorbing, displacing or metabolically active supplements (e.g. AST‐120 (Kremezin®), ibuprofen or folates) in different dialysis techniques [18, 23–2988–91]; and comparisons of two or more different techniques between each other (Fig.…”

Section: Resultsmentioning

confidence: 99%

Reduction of protein‐bound uraemic toxins in plasma of chronic renal failure patients: A systematic review

Saar-Kovrov

Zidek²,

Orth-Alampour³

et al. 2021

J Intern Med

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Reduction of proteinbound uraemic toxins in plasma of chronic renal failure patients: A systematic review (Review). J Intern Med 2021;Background. Protein-bound uraemic toxins (PBUTs) accumulate in patients with chronic kidney disease and impose detrimental effects on the vascular system. However, a unanimous consensus on the most optimum approach for the reduction of plasma PBUTs is still lacking.Methods. In this systematic review, we aimed to identify the most efficient clinically available plasma PBUT reduction method reported in the literature between 1980 and 2020. The literature was screened for clinical studies describing approaches to reduce the plasma concentration of known uraemic toxins. There were no limits on the number of patients studied or on the duration or design of the studies.Results. Out of 1274 identified publications, 101 studies describing therapeutic options aiming at the reduction of PBUTs in CKD patients were included in this review. We stratified the studies by the PBUTs and the duration of the analysis into acute (data from a single procedure) and longitudinal (several treatment interventions) trials. Reduction ratio (RR) was used as the measure of plasma PBUTs lowering efficiency. For indoxyl sulphate and p-cresyl sulphate, the highest RR in the acute studies was demonstrated for fractionated plasma separation, adsorption and dialysis system. In the longitudinal trials, supplementation of haemodialysis patients with AST-120 (Kremezin ® ) adsorbent showed the highest RR. However, no superior method for the reduction of all types of PBUTs was identified based on the published studies. Conclusions.Our study shows that there is presently no technique universally suitable for optimum reduction of all PBUTs. There is a clear need for further research in this field.

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Section: Resultsmentioning

confidence: 99%

Reduction of protein‐bound uraemic toxins in plasma of chronic renal failure patients: A systematic review

Saar-Kovrov

Zidek²,

Orth-Alampour³

et al. 2021

J Intern Med

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“…Moreover, during treatment with HFR the protein expression of HO-1 over time increased (p< 0.00001) and it approached the statistical significance versus time zero at six months (0.27±0.10 vs. 0.17± 0.11, P = 0.0527) and became significantly different from time zero at 9 (0.48 ±0. 20 Splendiani et al [56] have shown that the styrenic resin HFR cartridge is able to adsorb significant amounts of homocysteine without simultaneous adsorption of vit. B12 and folate: this suggests an important mechanism for reducing cardiovascular risk.…”

Section: Clinical Experiences With Hfrmentioning

confidence: 99%

Adsorption in Extracorporeal Blood Purification: How to Enhance Solutes Removal Beyond Diffusion and Convection

Grandi¹,

Bolasco²,

Palladino³

et al. 2013

Hemodialysis

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“…Prognosis in patients with KS limited to the skin is favorable while visceral involvement is associated with high mortality. Giorgio Splendiani et al (112) of the University Hospital Tor Vergata (Rome, Italy) investigated the effects of double chamber HDF with reinfusion of ultrafiltrate regenerated through a charcoal‐resin cartridge on the homocysteine (Hcy) levels in 10 patients. The data, which need confirmation in a long‐term study, seem to indicate that this technique is able to reduce Hcy levels not only through a likely reduction of uremic toxins, but also through an actual removal of Hcy by adsorbance onto the charcoal‐resin cartridge.…”

Section: Renal Support and Dialysismentioning

confidence: 99%

Artificial Organs 2004: A Year in Review

Malchesky¹

2005

Artificial Organs

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Selective Adsorption of Homocysteine Using HFR-on Line Technique

Cited by 4 publications

References 0 publications

Reduction of protein‐bound uraemic toxins in plasma of chronic renal failure patients: A systematic review

Reduction of protein‐bound uraemic toxins in plasma of chronic renal failure patients: A systematic review

Adsorption in Extracorporeal Blood Purification: How to Enhance Solutes Removal Beyond Diffusion and Convection

Artificial Organs 2004: A Year in Review

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