Selection of Patients for Sublingual Versus Subcutaneous Immunotherapy

Larenas‐Linnemann, Désirée; Blaiss, Michael S.

doi:10.2217/imt.14.55

Cited by 8 publications

(5 citation statements)

References 95 publications

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“…Recent findings agree on the fact that some interventions (i.e., patients' education, strict follow-up, regular contacts) could effectively improve the adherence [39] and the following Table 2 with actions to improve AIT adherence was proposed [40].…”

Section: Compliancesupporting

confidence: 55%

Allergic Sensitization and Rhinitis in Children: What Is New?

Larenas‐Linnemann

2015

Curr Treat Options Allergy

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Allergic rhinitis I Pediatric I House dust mite I Pollens I Skin prick test I Immunotherapy Opinion statement In children with nasal symptoms during several months, oftentimes with a chronically relapsing course, allergic rhinitis is one of the most probable diagnoses. This is often complicated with recurrent respiratory infections, as there is a circular causal loop between allergic rhinitis that increases the frequency of respiratory infections and the infections that exacerbate the allergic disease. As a consequence, in these children, the physician should intentionally search for allergic sensitization, in serologic specific IgE testing and/or with skin prick testing. If a possible allergic diathesis is further suspected because of a personal (atopic dermatitis) or a family history of allergic diseases, the search for allergic sensitization should begin at an even earlier age; in several cases, allergic sensitization can already be shown even before the age of two. In my opinion, in highly atopic children as soon as a specific allergic sensitization can be documented that coincide with the presence of symptoms on possible exposure, as obtained from the detailed history, allergen immunotherapy should be offered as an integral part of the treatment. It is very well plausible that the earlier in the development of the allergic disease, we can redirect the immune system, the better the results. However, in these young allergic children, I only choose sublingual immunotherapy (SLIT), being the option with the best safety profile. In our clinic, we have looked for several ways to improve adherence, which is an issue especially in SLIT. Among the several strategies we implemented are written information on the treatment and the administration schedule with a 20 min explanation by a specialized nurse at start, a flexible, 1-month up-dosing phase to reduce the frequency and intensity of local side effects and reduce the frequently seen flare in nasal symptoms, morning dosing, up-dosing under the cover of an antihistamine and a topical corticosteroid in the evening for 6 weeks, a close follow-up of the children by phone contacts, and an initial follow-up visit at 6 weeks.

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Section: Compliancesupporting

confidence: 55%

Allergic Sensitization and Rhinitis in Children: What Is New?

Larenas‐Linnemann

2015

Curr Treat Options Allergy

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“…The treatments used in these trials were not associated with an increased risk of local or systemic reactions. Future studies should use high quality allergen formulations with a proven track record in other allergic conditions and should include PROs as key outcome measures. SCIT versus SLIT Direct head‐to‐head comparisons of subcutaneous AIT (SCIT) versus sublingual AIT (SLIT; tablets or drops) are limited [113 ] and have generated contradictory results [114 ]. Similarly, indirect comparisons are inconsistent.…”

Section: Rationale Of Allergy Immunotherapy Across the Life Cycle In mentioning

confidence: 99%

“…SCIT versus SLIT Direct head‐to‐head comparisons of subcutaneous AIT (SCIT) versus sublingual AIT (SLIT; tablets or drops) are limited [113 ] and have generated contradictory results [114 ]. Similarly, indirect comparisons are inconsistent.…”

Section: Rationale Of Allergy Immunotherapy Across the Life Cycle In mentioning

confidence: 99%

Allergy immunotherapy across the life cycle to promote active and healthy ageing: from research to policies

Calderón

Demoly

Casale

et al. 2016

Clin Transl Allergy

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Allergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al treatment may be used in old age adults. The current paper was developed by a working group of AIRWAYS integrated care pathways for airways diseases, the model of chronic respiratory diseases of the European Innovation Partnership on active and healthy ageing (DG CONNECT and DG Santé). It considered (1) the political background, (2) the rationale for allergen immunotherapy across the life cycle, (3) the unmet needs for the treatment, in particular in preschool children and old age adults, (4) the strategic framework and the practical approach to synergize current initiatives in allergen immunotherapy, its mechanisms and the concept of active and healthy ageing.

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“…Adverse events are more frequent with SLIT than conventional therapy, although they are frequently less severe (ie, more local reactions). 43 Few studies have examined the efficacy and safety of SLITs specifically related to patients with CRS. With increasing familiarity and use of SLIT in patients with CRS, this is an area that deserves further attention.…”

Section: Complications Of Medical Therapymentioning

confidence: 99%