Selection of KPC-2–producing Providencia stuartii during treatment for septicemia

Aires, Caio Augusto Martins; Almeida, Anna; Vilela, Marinalda Anselmo; Morais-Junior, Marcos A.; Morais, Márcia Maria Camargo de

doi:10.1016/j.diagmicrobio.2015.09.013

Cited by 9 publications

(10 citation statements)

References 10 publications

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“…Nine of 29 reports mentioned whether or not the patients received prior antimicrobial therapy [5] , [11] , [13] , [15] , [18] , [19] , [20] , [21] ; all patients in the nine reports received antibiotics before detection of carbapenem-resistant Providencia species except one. In one outbreak of CRPS [5] , the elevated polymyxin B consumption in that ICU, because of high rates of Pseudomonas aeruginosa and A. baumannii, might be the cause of the emergence of CRPS.…”

Section: Patient Characteristicsmentioning

confidence: 99%

“…One patient with CRPS in this outbreak had received prior therapy with polymyxin before CRPS detection. Four patients with CRPS received colistin before the isolation of CRPS in two reports [20] , [21] . Six critically ill patients were infected with a CRPS isolate in one outbreak in Greece [11] , and three received prior therapy with colistin.…”

Section: Patient Characteristicsmentioning

confidence: 99%

“…VIM-19 β-lactamase was detected in one case of CRPS associated urinary tract infection [37] . KPC-2 was recovered from CRPS isolates in Brazil [21] , [38] . OXA-72 carbapenemase was isolated from P. rettgeri in Nepal [33] .…”

Section: Mechanisms Of Carbapenem Resistancementioning

confidence: 99%

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First literature review of carbapenem-resistant Providencia

Abdallah¹,

Balshi

2018

New Microbes and New Infections

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Providencia species are Gram-negative bacteria that belong to the Enterobacteriaceae family. They have intrinsic resistance to colistin and tigecycline, which makes treatment of the multidrug-resistant strains of Providencia challenging. Carbapenem-resistant Providencia species are increasingly reported. In this review, patients' characteristics, resistance mechanisms, treatment and infection control measures of carbapenem-resistant Providencia species in the literature are described.

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Section: Patient Characteristicsmentioning

confidence: 99%

Section: Patient Characteristicsmentioning

confidence: 99%

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First literature review of carbapenem-resistant Providencia

Abdallah¹,

Balshi

2018

New Microbes and New Infections

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“…Si bien K. pneumoniae es la principal especie productora de KPC, también se ha determinado su presencia en otras especies de la familia Enterobacteriaceae, como K. oxytoca, Salmonella enterica, E. coli, Proteus spp., Citrobacter freundii, Enterobacter spp., Raoultella ornithinolytica, Morganella morganii, Pantoea spp., Providencia spp. y S. marcescens [23][24][25][26][27][28][29] . Adicionalmente, se ha determinado la presencia de esta enzima en bacilos gramnegativos no fermentadores como A. baumannii, P. aeruginosa y Flavobacterium odoratum 17,[30][31] .…”

Section: Kpc (Klebsiella Pneumoniae Carbapenemasa)unclassified

KPC: Klebsiella pneumoniae carbapenemasa, principal carbapenemasa en enterobacterias

Vera-Leiva¹,

Barría-Loaiza²,

Carrasco-Anabalón³

et al. 2017

Rev. chil. infectol.

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The dissemination of carbapenemase-producing Enterobacteriaceae is currently considered a serious clinical problem due to the failure in the treatment of infections produced by them. Among the carbapenemases, the enzyme KPC has spread worldwide and has been identified in the main enterobacterial species related with healthcareassociated infections, although Klebsiella pneumoniae is the predominant specie. The blaKPC gene is transported, mainly by the transposon Tn4401, detected in various enterobacterial species of different sequence types (ST) and geographical origin. In addition, new genetic platforms that are distinguished, from Tn4401 because of insertions or deletions of other genes have been described. Plasmids containing the blaKPC gene can be conjugative and mobilizable non-conjugative plasmids, and can carry other genetic determinants of resistance. The KPC-producing strains may have different levels of resistance to carbapenems, due to the involvement of additional mechanisms such as different expression levels of porins and efflux pumps associated with the production of extended spectrum β-lactamases and/or AmpC. However, the carbapenemases, with KPC as the most common enzyme, provide higher levels of resistance.

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“…Providencia stuartii belongs to the Enterobacteriaceae family and is commonly associated with urinary tract infections. However, it can cause other infections such as diarrhea, pneumonia, and septicemia [1][2][3] . One of the main causes of the pathogenicity of this species is its intrinsic resistance to various antimicrobials including some β-lactams and aminoglycosides, as well as tigecycline, colistin, and polymyxin B, which are used when resistance to carbapenems is present 4 .…”

mentioning

confidence: 99%

First report of the aac(6’)-Ib-cr gene in Providencia stuartii isolates in Brazil

Silva

Ramos

Lima

et al. 2021

Rev. Soc. Bras. Med. Trop.

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INTRODUCTION: The aac(6’)-Ib-cr and bla KPC genes are spreading among Enterobacteriaceae species, including Providencia stuartii , in some countries of world. METHODS: These genes were investigated in 28 P. stuartii isolates from a public hospital in Recife, Pernambuco, Brazil, by PCR and sequencing. RESULTS: The aac(6’)-Ib-cr gene was detected in 16 resistant isolates, and the bla KPC gene was seen in 14. CONCLUSIONS: The presence of these genes in P. stuartii multi- and extensively drug-resistant isolates indicates that the resistance arsenal of this species is increasing, thus limiting the therapeutic options.

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Selection of KPC-2–producing Providencia stuartii during treatment for septicemia

Cited by 9 publications

References 10 publications

First literature review of carbapenem-resistant Providencia

First literature review of carbapenem-resistant Providencia

KPC: Klebsiella pneumoniae carbapenemasa, principal carbapenemasa en enterobacterias

First report of the aac(6’)-Ib-cr gene in Providencia stuartii isolates in Brazil

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