Selection of High Risk Groups Among Prognostically Favorable Patients with Breast Cancer

Abstract

In a prospective, nationwide, decentralized breast cancer project conducted by The Danish Breast Cancer Cooperative Group (DBCG) the recurrence rate within the first year after surgery was analysed in relation to tumor anaplasia. One thousand forty-eight patients met the requirements of eligibility, i.e. tumor size less than or equal to 5 cm with negative axillary nodes, and no skin or deep invasion. The recurrence rates in tumors with anaplasia Grades I, II, and III were 4, 9, and 14%, respectively (p = 0.001). Therefore, it seems possible, prospectively, among otherwise prognostically favorable patients, to select a group with high risk of recurrence which might benefit from adjuvant systemic therapy.

Molecular and Morphologic Distinctions between Infiltrating Ductal and Lobular Carcinoma of the Breast

“…Well‐differentiated (grade 1) IDC have a have a low Bloom–Richardson score (3–5), while intermediate grade (grade 2) tumors have a score from six to seven and poorly differentiated (grade 3) tumors have a score from eight to nine. The prognostic importance of histologic grade has been repeatedly tested and shown to directly correlate with the frequency of lymph node metastasis, the frequency of disease recurrence and death caused by invasive carcinoma, all independent of clinical stage (8–15).…”

Influence of diet on breast cancer size and morphology in rats treated with DMBA

“…This gave a total score of 56 U. Torsten et al 3-9, and the grades were arbitrarily assigned as follows: grade I -3, 4 or 5 points; grade II -6 or 7 points; grade I I I -8 or 9 points. The Bloom and Richardson method has now been used in a substantial number of studies (Wolff 1966, Hamlin 1968, Tough et al 1969, Champion et al 1972, Andersen et al 1981, Elston et al 1982, Parl and Dupont 1982, Elston 1984 and in all it has been found to be both practical and useful in determining prognosis. E.g.…”