Selection of different endothelialization modes and different seed cells for tissue-engineered vascular graft

Cai, Qingjin; Liao, Wanshan; Xue, Fangchao; Wang, Xiaochen; Zhou, Wei; Li, Yanzhao; Zeng, Wen

doi:10.1016/j.bioactmat.2020.12.021

Cited by 28 publications

(13 citation statements)

References 201 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another shortcoming of adding synthetic polymers is an excessive infiltration of the graft by immune cells which thereby represent a majority of the cells within the regenerating blood vessel [20][21][22]. Further, the blending of natural and synthetic polymers does not improve haemocompatibility of the grafts, as rapid and complete endothelialisation of long vascular grafts, which is an important prerequisite to prevent thrombosis, is relatively rare [13,23,24]. To overcome this drawback, antiplatelet or anticoagulant drugs might be conjugated to a scaffold luminal surface [13].…”

Section: Introductionmentioning

confidence: 99%

Tissue-Engineered Carotid Artery Interposition Grafts Demonstrate High Primary Patency and Promote Vascular Tissue Regeneration in the Ovine Model

et al. 2021

View full text Add to dashboard Cite

Tissue-engineered vascular graft for the reconstruction of small arteries is still an unmet clinical need, despite the fact that a number of promising prototypes have entered preclinical development. Here we test Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)Poly(ε-caprolactone) 4-mm-diameter vascular grafts equipped with vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and stromal cell-derived factor 1α (SDF-1α) and surface coated with heparin and iloprost (PHBV/PCL[VEGF-bFGF-SDF]Hep/Ilo, n = 8) in a sheep carotid artery interposition model, using biostable vascular prostheses of expanded poly(tetrafluoroethylene) (ePTFE, n = 5) as a control. Primary patency of PHBV/PCL[VEGF-bFGF-SDF]Hep/Ilo grafts was 62.5% (5/8) at 24 h postimplantation and 50% (4/8) at 18 months postimplantation, while all (5/5) ePTFE conduits were occluded within the 24 h after the surgery. At 18 months postimplantation, PHBV/PCL[VEGF-bFGF-SDF]Hep/Ilo grafts were completely resorbed and replaced by the vascular tissue. Regenerated arteries displayed a hierarchical three-layer structure similar to the native blood vessels, being fully endothelialised, highly vascularised and populated by vascular smooth muscle cells and macrophages. The most (4/5, 80%) of the regenerated arteries were free of calcifications but suffered from the aneurysmatic dilation. Therefore, biodegradable PHBV/PCL[VEGF-bFGF-SDF]Hep/Ilo grafts showed better short- and long-term results than bio-stable ePTFE analogues, although these scaffolds must be reinforced for the efficient prevention of aneurysms.

show abstract

Section: Introductionmentioning

confidence: 99%

Tissue-Engineered Carotid Artery Interposition Grafts Demonstrate High Primary Patency and Promote Vascular Tissue Regeneration in the Ovine Model

et al. 2021

View full text Add to dashboard Cite

show abstract

“…A closer analog to clinical conditions allows one to better predict graft healing and regeneration in clinic. A huge discrepancy exists between endothelialization outcomes in animal models and those occurring in clinic ( Zilla et al, 2007 ; Sánchez et al, 2018 ; Cai et al, 2021 ). Despite increased graft assessments in different animal models, most studies still use young, healthy small animals.…”

Section: Translation Of Vascular Grafts For Clinics: Success Measuresmentioning

confidence: 99%

Strategies to counteract adverse remodeling of vascular graft: A 3D view of current graft innovations

Tan

Boodagh

Parthiban

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Vascular grafts are widely used for vascular surgeries, to bypass a diseased artery or function as a vascular access for hemodialysis. Bioengineered or tissue-engineered vascular grafts have long been envisioned to take the place of bioinert synthetic grafts and even vein grafts under certain clinical circumstances. However, host responses to a graft device induce adverse remodeling, to varied degrees depending on the graft property and host’s developmental and health conditions. This in turn leads to invention or failure. Herein, we have mapped out the relationship between the design constraints and outcomes for vascular grafts, by analyzing impairment factors involved in the adverse graft remodeling. Strategies to tackle these impairment factors and counteract adverse healing are then summarized by outlining the research landscape of graft innovations in three dimensions—cell technology, scaffold technology and graft translation. Such a comprehensive view of cell and scaffold technological innovations in the translational context may benefit the future advancements in vascular grafts. From this perspective, we conclude the review with recommendations for future design endeavors.

show abstract

“…Vascular grafts (also called vascular scaffolds) have always been a clinically effective treatment strategy for large vascular defects caused by vascular disease or violent invasion [ 4 , 79 , 80 ], such as polyurethane (PU) [ 81 ], polyester (PET) [ 82 ], ePTFE [ 83 ], etc. Although these vascular grafts, when used in larger-diameter vessels (>6 mm) show satisfactory long-term performance, they display inferior performance in small-diameter vessels (<6 mm), mainly because they are prone to intimal hyperplasia (IH) and thrombogenesis [ 84 ]. Given the above-mentioned unsatisfactory factors and the shortcomings of secondary operations caused by non-degradability, it has always been a goal to seek natural materials with better biocompatibility to construct vascular grafts.…”

Section: Mnps For Vascular Repairmentioning

confidence: 99%

Vascular Repair by Grafting Based on Magnetic Nanoparticles

et al. 2022

View full text Add to dashboard Cite

Magnetic nanoparticles (MNPs) have attracted much attention in the past few decades because of their unique magnetic responsiveness. Especially in the diagnosis and treatment of diseases, they are mostly involved in non-invasive ways and have achieved good results. The magnetic responsiveness of MNPs is strictly controlled by the size, crystallinity, uniformity, and surface properties of the synthesized particles. In this review, we summarized the classification of MNPs and their application in vascular repair. MNPs mainly use their unique magnetic properties to participate in vascular repair, including magnetic stimulation, magnetic drive, magnetic resonance imaging, magnetic hyperthermia, magnetic assembly scaffolds, and magnetic targeted drug delivery, which can significantly affect scaffold performance, cell behavior, factor secretion, drug release, etc. Although there are still challenges in the large-scale clinical application of MNPs, its good non-invasive way to participate in vascular repair and the establishment of a continuous detection process is still the future development direction.

show abstract

Selection of different endothelialization modes and different seed cells for tissue-engineered vascular graft

Cited by 28 publications

References 201 publications

Tissue-Engineered Carotid Artery Interposition Grafts Demonstrate High Primary Patency and Promote Vascular Tissue Regeneration in the Ovine Model

Tissue-Engineered Carotid Artery Interposition Grafts Demonstrate High Primary Patency and Promote Vascular Tissue Regeneration in the Ovine Model

Strategies to counteract adverse remodeling of vascular graft: A 3D view of current graft innovations

Vascular Repair by Grafting Based on Magnetic Nanoparticles

Contact Info

Product

Resources

About