Selection methodology with scoring system: Application to Mexican plants producing podophyllotoxin related lignans

Lautie, Emmanuelle; Quintero, Rodolfo; Fliniaux, Marc‐André; Villarreal, Marı́a Luisa

doi:10.1016/j.jep.2008.09.014

Cited by 31 publications

(32 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Random screening is employed when the number of candidates is low and/or the research means are ample (Lautié et al, 2008). Chemotaxonomy distinguishes related species by their production of different secondary metabolites, different ecological features and different physiological characteristics.…”

Section: Introductionmentioning

confidence: 99%

Mexican medicinal plants used for cancer treatment: Pharmacological, phytochemical and ethnobotanical studies

Alonso-Castro

Villarreal

Salazar‐Olivo

et al. 2011

Journal of Ethnopharmacology

254

127

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Mexican medicinal plants used for cancer treatment: Pharmacological, phytochemical and ethnobotanical studies

Alonso-Castro

Villarreal

Salazar‐Olivo

et al. 2011

Journal of Ethnopharmacology

254

127

View full text Add to dashboard Cite

“…[5] Actually, PTOX is extracted from the plant material of the species Podophyllum peltatum and Podophyllum emodi , which are now categorized as endangered species, and whose in vitro propagation has as yet proven to be complicated. [6] The development of the drugs etoposide, teniposide, and etopofos, have increased the demand for PTOX, both to carry out the synthesis of such derivatives, and also for research purposes. [7] Among investigated new natural sources that accumulate PTOX are included the plant species Linum album ,[8] Callitris drummondii ,[9] Jeffersonian chinensis ,[10] Linum scabellrum , and Hyptis suaveolens [6] used in this investigation.…”

Section: Introductionmentioning

confidence: 99%

“…The presence of PTOX in the plant species H. suaveolens has been reported in both aerial parts and in roots[6] H. suaveolens , (“Chan” or “Chia de Colima”) was an important source of food and medicine in pre-hispanic Mexico. [14] Nowadays H. suaveolens is used traditionally for the treatment of respiratory diseases, fever, skin diseases, pain, and cramps.…”

Section: Introductionmentioning

confidence: 99%

Production of podophyllotoxin from roots and plantlets of Hyptis suaveolens cultivated in vitro

Velóz¹,

Cardoso-Taketa²,

Villarreal³

2013

Phcog Res

View full text Add to dashboard Cite

Background:Hyptis suaveolens was an important source of food and medicines in pre-hispanic Mιxico and is actually used popularly to treat respiratory and skin diseases, fever, pain, and cramps, between other ailments. In 2008 the presence of podophyllotoxin (PTOX) was reported in this plant.Objective:To establish in vitro cultures of H. suaveolens able to produce PTOX.Materials and Methods:Explants of H. suaveolens were cultivated in Murashige and Skoog (MS) medium supplemented with different concentrations of the phytohormones 6-benzylaminopurine (6-BAP), 2,4-dichlorophenoxyacetic acid (2,4-D), 1-naphthaleneacetic acid (NAA) and kinetin (Kin), in order to induce the production of podophyllotoxin. Root cultures without hormones were also established and the quantification of PTOX was performed by HPLC analysis.Results:The presence of growth regulators during in vitro cultivation of H. suaveolens, provoked morphological variations in explants, and induced the accumulation of different levels of PTOX. Roots grown without phytohormones accumulated PTOX at 0.013% dry weight (DW), while in three of the callus cultures cell lines growing together with roots, PTOX accumulated at concentrations of 0.003, 0.005 and 0.006% DW when NAA was combined with either Kin or BAP. In wild plant material PTOX was present in trace amounts in the aerial parts, while in the roots it was found at 0.005% DW.Conclusion:This study demonstrated that although it is possible to obtain PTOX in a variety of in vitro cultures of H. suaveolens, in vitro roots grown without the addition of growth regulators were better producers of PTOX.

show abstract

“…According to the WHO, it is estimated that 60% of antitumoral medicines are derived, either directly or indirectly, from medicinal plants (Robinson and Zhang, 2011). A large majority of anticancer drugs used currently, or still undergoing clinical trials, are derived from natural sources (Efferth et al, 2007;Lautiéa et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Bryonia dioica aqueous extract induces apoptosis through mitochondrial intrinsic pathway in BL41 Burkitt's lymphoma cells

Benarba

Meddah

Aoues

2012

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Selection methodology with scoring system: Application to Mexican plants producing podophyllotoxin related lignans

Cited by 31 publications

References 67 publications

Mexican medicinal plants used for cancer treatment: Pharmacological, phytochemical and ethnobotanical studies

Mexican medicinal plants used for cancer treatment: Pharmacological, phytochemical and ethnobotanical studies

Production of podophyllotoxin from roots and plantlets of Hyptis suaveolens cultivated in vitro

Bryonia dioica aqueous extract induces apoptosis through mitochondrial intrinsic pathway in BL41 Burkitt's lymphoma cells

Contact Info

Product

Resources

About