Selection for growth rate and body size have altered the expression profiles of somatotropic axis genes in chickens

Jia, Junjing; Ahmed, Irfan; Liu, Lixian; Liu, Yong; Xu, Zhiqiang; Duan, Xiaohua; Li, Qihua; Dou, Tengfei; Gu, Dahai; Hua, Rong; Wang, Kun; Li, Zhengtian; Talpur, Mir Zulqarnain; Huang, Ying; Wang, Shanrong; Yan, Shixiong; Tong, Huiquan; Zhao, Sumei; Zhao, Guiping; Pas, M.F.W. te; Su, Zhengchang; Ge, Chao

doi:10.1371/journal.pone.0195378

Cited by 39 publications

(47 citation statements)

References 49 publications

(62 reference statements)

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“…No difference was found between broiler and Fayoumi chicken (expression of GH, IGF1,myostatin and ghrelin gene is equal in both broiler and Fayoumi chicken as they not receive any food ) While w2 ,w4 ,w6 ,w8 in broiler chicken had a significant higher expression of GH gene than Fayoumi chicken , broiler chicken had a significant lower expression of myostatin gene than Fayoumi chicken and by aging or by increasing weight ,myostatin gene expression decreased. Similar results, Avian broilers had significantly increased hepatic GH mRNA levels (Jia et al, 2018). Variations in feed intake were observed between high and low growth rate chickens due to differences in gene expression (Yin et al, 2014).…”

Section: Discussionsupporting

confidence: 69%

Genetic and Hormonal Difference between High Growth Rate Breed (Cobb Broiler chicken) and Low Growth Rate Breed (Native Fayoumi chicken)

Antar¹,

Shosha

Elazab

et al. 2020

Benha Veterinary Medical Journal

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The present study aimed to investigate the genetic and hormonal differences between low (Native Fayoumi) and high (Cobb Broiler) growth gate breeds of chicken. A total number of 100 one-day-old Fayoumi chicks and 100 one-day-old Cobb chicks were used. Chicks of each breed were allocated into three equal replicates. The growth parameters [body weight, Body weight gain (BWG) and Feed conversion ratio (FCR)], genetic expression of some growth-related genes (growth hormone, insulin like growth factor1, ghrelin and Myostatin gene) and plasma level of some growth-related hormones (Insulin, T3, T4 and corticosterone) were recorded. The obtained results revealed that, Cobb chicken had significantly higher (p<0.05) body weight, BWG and feed intake than Fayoumi chicken but the FCR of Fayoumi chicken was higher (p<0.05) than that of broiler chicken. Cobb recorded significantly (p<0.05) lower plasma level of corticosterone, T3 and T4 than Fayoumi chicken while Insulin is higher (p<0.05) in cobb chicken. Cobb recorded highly significant (p<0.05) values of GH, IGF1 and ghrelin Gene expression while myostatin gene expression was higher (p<0.05) in Fayoumi chicken than in Cobb. From the obtained results it could be concluded that, the observed high growth rate in cobb chicken may be attributed the difference in gene expression related growth as well as hormonal difference.

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Section: Discussionsupporting

confidence: 69%

Genetic and Hormonal Difference between High Growth Rate Breed (Cobb Broiler chicken) and Low Growth Rate Breed (Native Fayoumi chicken)

Antar¹,

Shosha

Elazab

et al. 2020

Benha Veterinary Medical Journal

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“…These results indicate low IGF-1 sensitivity of the hypothalamus of broiler chicks. Jia et al (2018) reported that broiler chicks showed higher plasma IGF-1 concentration than native chicken breeds. Fast-growing broilers had higher concentrations of IGF-1 in the serum than slow-growing broilers (Xiao et al, 2017).…”

Section: Resultsmentioning

confidence: 99%

Role of Insulin-like Growth Factor-1 in the Central Regulation of Feeding Behavior in Chicks

et al. 2019

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Insulin-like growth factor-1 (IGF-1) is a key regulator of muscle development and metabolism in chickens. Recently, we have demonstrated that intracerebroventricular administration of IGF-1 significantly decreased food intake in broiler chicks. However, the molecular mechanisms underlying the IGF-1-induced anorexia and the anorexigenic effect of IGF-1 in different strains of commercial chicks have not been investigated. Neuropeptide Y (NPY, a hypothalamic orexigenic neuropeptide), agouti-related protein (AgRP, a hypothalamic orexigenic neuropeptide), and proopiomelanocortin (POMC, the precursor of hypothalamic anorexigenic neuropeptides) play important roles in the regulation of food intake in both mammals and chickens. Evidence shows that several cell signaling pathways in the hypothalamus are involved in regulating the feeding behavior of mammals. In the present study, we first investigated the effects of IGF-1 on the expression of appetite-regulating neuropeptides and phosphorylation of signaling molecules in the hypothalamus of broiler chicks. Intracerebroventricular administration of IGF-1 significantly increased the mRNA levels of POMC, whereas the mRNA levels of NPY and AgRP were not significantly altered. IGF-1 also significantly induced the phosphorylation of v-Akt murine thymoma viral oncogene homolog 1 (AKT) in the hypothalamus of chicks, but did not influence the phosphorylation of forkhead box O1, S6 protein, AMP-activated protein kinase, and extracellular signal-regulated kinase 1/2. We also compared the effect of IGF-1 on food intake in broiler chicks (a hyperphagic strain of chickens) and layer chicks. Results demonstrated that the threshold of IGF-1-induced anorexia in broiler chicks was higher than that in layer chicks. Our observations suggest that hypothalamic POMC and AKT may be involved in the IGF-1-induced anorexigenic pathway and that high threshold of IGF-1-induced anorexia in broiler chicks might be one of the causes of hyperphagia in broiler chicks. Overall, it appears that IGF-1 plays important roles in the central regulation of feeding behavior in chicks.

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“…Consequently, the somatotropic axis genes and their regulatory sequences are likely to be promising candidate biomarkers to understand selection response for growth rate and meat yield and to improve these traits in chickens (Jia et al, 2018). Berri et al (2001) stated that the meat from the genotypes with greater muscle mass showed a decreased content of heme pigments (Iron ppm) and a decreased level of glycogen store.…”

Section: Genetic Control Of Poultry Meat Qualitymentioning

confidence: 99%

Review on Slow and Fast Growing Chicken Varieties Physicochemical Qualities

Katekhaye¹

2019

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India is the fourth largest chicken producer after China, Brazil, and the USA. The per capita consumption of chicken has gone up from 400 gm to 2.5 kg per year, and human nutritionists recommend 10 kg chicken per year. To feed billions of Indian population, there is a lot of scope for the chicken industry to enhance the production. At the same time, many studies revealed that genotype significantly affects functional properties as well as the nutritional characteristics of chicken. The fast-growing chicken strains appear to be more attractive both for industrial and consumer use whereas from a nutritional point of view meat from slow growing chicken strains appears healthier (less fat and higher content of n-3 PUFA) and thus might better fit with the consumer's prospect. In acceptability for meat quality, slow growing chicken showed the better sensory quality of the chicken breast meat. Thus, for the demand of customer's for the higher quality of chicken meat, it is suggested to use slow growing chicken in alteration to fast-growing broilers. This review deals with the effects of genotypes (slow growing and fast growing broilers) on physicochemical and organoleptic traits of chicken.

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Selection for growth rate and body size have altered the expression profiles of somatotropic axis genes in chickens

Cited by 39 publications

References 49 publications

Genetic and Hormonal Difference between High Growth Rate Breed (Cobb Broiler chicken) and Low Growth Rate Breed (Native Fayoumi chicken)

Genetic and Hormonal Difference between High Growth Rate Breed (Cobb Broiler chicken) and Low Growth Rate Breed (Native Fayoumi chicken)

Role of Insulin-like Growth Factor-1 in the Central Regulation of Feeding Behavior in Chicks

Review on Slow and Fast Growing Chicken Varieties Physicochemical Qualities

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