Role of Insulin-like Growth Factor-1 in the Central Regulation of Feeding Behavior in Chicks

Abstract

Insulin-like growth factor-1 (IGF-1) is a key regulator of muscle development and metabolism in chickens. Recently, we have demonstrated that intracerebroventricular administration of IGF-1 significantly decreased food intake in broiler chicks. However, the molecular mechanisms underlying the IGF-1-induced anorexia and the anorexigenic effect of IGF-1 in different strains of commercial chicks have not been investigated. Neuropeptide Y (NPY, a hypothalamic orexigenic neuropeptide), agouti-related protein (AgRP, a hypothalamic orexigenic neuropeptide), and proopiomelanocortin (POMC, the precursor of hypothalamic anorexigenic neuropeptides) play important roles in the regulation of food intake in both mammals and chickens. Evidence shows that several cell signaling pathways in the hypothalamus are involved in regulating the feeding behavior of mammals. In the present study, we first investigated the effects of IGF-1 on the expression of appetite-regulating neuropeptides and phosphorylation of signaling molecules in the hypothalamus of broiler chicks. Intracerebroventricular administration of IGF-1 significantly increased the mRNA levels of POMC, whereas the mRNA levels of NPY and AgRP were not significantly altered. IGF-1 also significantly induced the phosphorylation of v-Akt murine thymoma viral oncogene homolog 1 (AKT) in the hypothalamus of chicks, but did not influence the phosphorylation of forkhead box O1, S6 protein, AMP-activated protein kinase, and extracellular signal-regulated kinase 1/2. We also compared the effect of IGF-1 on food intake in broiler chicks (a hyperphagic strain of chickens) and layer chicks. Results demonstrated that the threshold of IGF-1-induced anorexia in broiler chicks was higher than that in layer chicks. Our observations suggest that hypothalamic POMC and AKT may be involved in the IGF-1-induced anorexigenic pathway and that high threshold of IGF-1-induced anorexia in broiler chicks might be one of the causes of hyperphagia in broiler chicks. Overall, it appears that IGF-1 plays important roles in the central regulation of feeding behavior in chicks.

Impact of Long-Term HFD Intake on the Peripheral and Central IGF System in Male and Female Mice

“…Considering the insulin-like actions of IGF1 and 2, it is possible that the rise in these factors with HFD intake contributes to the inhibition of orexigeneic neuropeptide expression. Administration of IGF icv has been shown to increase POMC mRNA levels in chicks [ 90 ], which was not observed here. This difference could be due to the difference in species.…”

Transcriptome Analysis Identifies Candidate Genes and Signaling Pathways Associated With Feed Efficiency in Xiayan Chicken

“…Some genes enriched in the insulin signaling pathway were upregulated in the HRFI group. In the chicken, the insulin-signaling pathway has anabolic effects in glucose transport and utilization, glycogen synthesis, control of liver lipogenic enzymes, amino acid transport, and protein synthesis ( Fujita et al, 2019 ). Previous genome-wide association analysis identified an SNP site significantly related to feed efficiency that may regulate feed efficiency through the insulin signaling pathway ( Yuan et al, 2017 ).…”

Indexs in About The Authors Adi Susanto ORCID iD Universitas Gadjah Mada Indonesia Nico Chandra Aditya Fakultas Biologi, Universitas Gadjah Mada Indonesia Sari'ah Cintami Damayanti Fakultas Biologi, Universitas Gadjah Mada Indonesia Hendry Saragih Fakultas Biologi, Universitas Gadjah Mada User You are logged in as... widi_1 My Profile Log Out Notifications View (59 new) Manage Journal Content Search Search Scope Browse By Issue By Author By Title Information For

“…Flavonoid juga dapat meningkatkan pertumbuhan ayam dan meningkatkan pertumbuhan otot pada ayam (Fujita et al, 2019;Zhou et al, 2019). Berdasarkan keterangan di atas dapat diketahui bahwa penggunaan infused water buah naga merah yang berikan pada kelompok P4 (Perlakuan 4) telah merangsang pertumbuhan tulang dan otot pada ayam broiler selama masa perlakuan (21 hari).…”

“…Peningkatan bobot ayam dapat disebabkan oleh pemberian flavonoid, dimana flavonoid akan mengatur regulasi hormon pertumbuhan dan meningkatkan produksi IGF-I (Setiawan et al, 2018). IGF-I memiliki peran penting dalam pertumbuhan ayam broiler, IGF-I telah menjadi pengatur utama dalam metabolisme dan perkembangan otot ayam (Fujita et al, 2019). Pada tahap perkembangan embrio, IGF-I berperan penting dalam myogenesis, selain itu IGF-I juga berperan dalam proliferasi mioblas (Yu et al, 2015).…”