Selecting anesthetic agents for human safety and animal recovery surgery

Stimpfel, Teresa M.; Gershey, Edward L.

doi:10.1096/fasebj.5.7.2010062

Cited by 23 publications

(10 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…cate that the improved work practice controls, additional procedure-specific training, and the use of the anesthesia evacuation pump coupled with an absorbent cylinder greatly reduced the level of detectable WAG in the room from 500 ppm to less than 25 ppm. Re-educating technicians about the anesthesia circuit and how to inspect the circuit was also useful, as halogenated anesthetic gases can deteriorate rubber (Stimpfel & Gershey, 1991). Monitoring the level of isoflurane in the room as well as the level of employee exposure will be performed periodically.…”

Section: Completion At End Of Daymentioning

confidence: 99%

“…Isoflurane provides smooth muscle relaxation and, unlike other halogenated gases such as halothane and enflurane, does not cause cardiac arrhythmias, cardiac depression, or seizures (Stimpfel & Gershey, 1991) in the animal subjects. When used with a precision vaporizer, isoflurane allows the veterinarian to maintain the animal on a desirable plane of anesthesia until the completion of surgery, after which a rapid recovery time is typically observed.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Engineering and Work Practice Controls for the use of Anesthetic Gases during BSL-3 Rabbit Studies

Homer

Heflin

Manning³

et al. 2011

Appl Biosaf.

View full text Add to dashboard Cite

Anesthetic gases such as halogenated gases used independently or in conjunction with nitrous oxide are utilized to sedate animals prior to surgery. Acute and chronic exposure to anesthetic gas poses a risk to human health; therefore, appropriate controls must be utilized to protect the health of employees handling anesthetic gases. Engineering controls and work practice controls were developed at the University of Pittsburgh Regional Biocontainment Laboratory (RBL) to protect workers from exposure to levels of waste anesthetic gases (WAG) that exceed the recommended exposure limit (REL). Additionally, a decontamination strategy for monitoring badges was developed so that the monitoring badges used in BSL-3 facilities to detect and quantify WAG exposure could be safely analyzed outside of the BSL-3. Articles

show abstract

Section: Completion At End Of Daymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Engineering and Work Practice Controls for the use of Anesthetic Gases during BSL-3 Rabbit Studies

Homer

Heflin

Manning³

et al. 2011

Appl Biosaf.

View full text Add to dashboard Cite

show abstract

“…Concerns have been expressed over the safety of veterinary personnel working with gaseous anaesthetics, and recommendations made for ventilation and scavenging systems (Schuchman et al, 1975;Anon, 1987;Milligan et al, 1980;Dreesen et al, 1981;Green, 1981;Wingfield et al, 1981;Ward & Byland, 1982a,b;Potts & Craft, 1988;Burkhart & Stobbe, 1990;Gardner et al, 1991;Stimpfel & Gershey, 1991;Moore et al, 1993;Korczynski, 1999). There are no well documented reports of liver or any other disease associated with halothane exposure in veterinarians although there have been reports of hepatotoxicity in laboratory workers (Johnson & Mendelsohn, 1971;Sutherland & Smith, 1992).…”

Section: Anaestheticsmentioning

confidence: 99%

Veterinary pharmacovigilance. Part 4. Adverse reactions in humans to veterinary medicinal products

Woodward¹

2005

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

Although seemingly rare, adverse reactions to veterinary products do occur. These may arise from inadvertent exposure during use or as a result of occupational accidents. They are often mild in nature and include adverse effects such as minor skin reactions. However, more serious reactions may occur, and they are not restricted to the effects of the veterinary medicines themselves. For example, high-pressure injection injuries may occur as a result of accidents occurring during animal vaccination operations. This paper reviews some of these events, mentions where appropriate the regulatory actions taken, and describes some of the measures used to minimise such effects in the future, and serves to bring the issues discussed here to the attention of pharmacologists, pharmacoepidemiologists and others who train those who use veterinary medicinal products.

show abstract

“…(4) Halothane, a more potent anesthetic than iso¯urane, has disadvantages, which include depression of respiration, blood pressure, and heart rate, induc tion of cardiac arrhythm ias, and catecholamine sensitization. (3) Few studies exist on waste anesthetic gas exposures in the veterinary industry, including the epidem iology and health effects experienced by veterinary workers. Special hazards exist for the increasing num ber of wom en in the veterinary profession, in particular those who are pregnant.…”

mentioning

confidence: 99%

“…(2) Iso¯urane has the greatest margin of cardiovascular safety, producing m inim al cardiovascular depression and not inducing arrhythm ias. (3) Iso¯urane m etabolizes to a lesser extent than halothane and is viewed as a safer inhalation anesthetic. (4) Halothane, a more potent anesthetic than iso¯urane, has disadvantages, which include depression of respiration, blood pressure, and heart rate, induc tion of cardiac arrhythm ias, and catecholamine sensitization.…”

mentioning

confidence: 99%

Anesthetic Gas Exposure in Veterinary Clinics

Korczynski¹

1999

Applied Occupational and Environmental Hygiene

View full text Add to dashboard Cite

Concerns were raised by several workers from veterinary clinics in Manitoba, Canada, regarding potential exposure to isoflurane and halothane during anesthetic administration. There has been no guideline established for isoflurane by the American Conference of Governmental Industrial Hygienist (ACGIH) or a Permissible Exposure Limit by the Occupational Safety and Health Administration (OSHA) or a recommended exposure limit (REL) by the National Institute for Occupational Safety and Health (NIOSH). The ACGIH TLV-TWA for halothane is 50 ppm and NIOSH has established 2 ppm as a recommended level based on an one-hour sampling. OSHA has established no guideline for halothane. The Miran IB Portable Ambient Air Analyzer was used to conduct real-time sampling and to identify leaks during administration. All veterinary clinics inspected had installed the passive waste gas scavenging system. Ten clinics were each monitored during anesthetic gas delivery for one surgical procedure performed. Induction was 4 to 5 percent and maintenance 1.5 to 2.5 percent. Nine clinics were small animal practices and the tenth was an equine clinic. Veterinarians' personal exposures were higher than the assistants'. Veterinarians' personal exposures for isoflurane ranged from 1.3 to 13 ppm (AM = 5.3; SD +/- 2.7; GM = 4.6; GSD +/- 1.6) and for their assistants, personal exposures ranged from 1.2 to 9 ppm (AM = 4.7; SD +/- 2.5; GM = 3.9; GSD +/- 1.6). Veterinarians' personal exposures for halothane ranged from 0.7 to 12 ppm (AM = 4.2; SD +/- 3.6; GM = 2.9; GSD +/- 1.4) and for their assistants, personal exposures ranged from 0.4 to 3.2 ppm (AM = 1.8; SD +/- 1.0; GM = 1.5; GSD +/- 1.7). One clinic had significant leaks in the anesthetic gas delivery lines. Personal halothane exposure for the veterinarian at this clinic was 7.2 to 65 ppm (AM = 18.0; SD +/- 11.5; GM = 15.9; GSD +/- 1.8). Based on this study, worker exposures were acceptable. Peak exposures were recorded when the cuffed endotracheal tube was removed from the animal. Equipment leaks were minimal when the system was maintained at its optimum operating condition.

show abstract

Selecting anesthetic agents for human safety and animal recovery surgery

Cited by 23 publications

References 10 publications

Engineering and Work Practice Controls for the use of Anesthetic Gases during BSL-3 Rabbit Studies

Engineering and Work Practice Controls for the use of Anesthetic Gases during BSL-3 Rabbit Studies

Veterinary pharmacovigilance. Part 4. Adverse reactions in humans to veterinary medicinal products

Anesthetic Gas Exposure in Veterinary Clinics

Contact Info

Product

Resources

About