Selected Rat Strains Ht, Lt As A Model For The Study Of Dysadaptation States Dependent On The Level Of Excitability Of The Nervous System

Vaido, A. I.; Shiryaeva, N. V.; Pavlova, M. B.; Levina, A. S.; Хлебаева, Диана Азрет-Алиевна; Lyubashina, O. A.; Dyuzhikova, N. A.

doi:10.29296/2618723x-2018-03-02

Cited by 9 publications

(18 citation statements)

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“…Since the 10th generation, breeding has reached a plateau. At the same time, the 4-fold differences between the strains significantly exceeded the intrastrain variability [14].…”

Section: Animals and Stress Protocolmentioning

confidence: 90%

“…The experiments were performed on 5-month-old adult males of two rat strains differing in excitability of the peripheral and central nervous systems [14,16], which were selected over 80 generations for a high threshold (HT strain) and low threshold (LT strain) of excitability of the tibial nerve (n. tibialis) to electric current.…”

Section: Animals and Stress Protocolmentioning

confidence: 99%

“…The protocol was approved by the Commission on humane treatment of animals of Pavlov Institute of physiology of Russian Academy of Sciences. Experimental animals were subjected to psychogenic long-term emotional and painful stress according to the K. Hecht protocol [14]: every day for consecutive 15 days animals were subjected to 6 unsupported (10 seconds each) and 6 current-reinforced (2.5 mA, 2 ms) light signals. According to the scheme, the combinations of conditional and unconditional stimuli were not repeated but alternated with a probability of 0.5 which did not allow the animals to develop a conditioned reflex.…”

Section: Animals and Stress Protocolmentioning

confidence: 99%

“…It was shown that rat strains differ in their behavioral responses to stress, and are also characterized by distinct molecular and cytological features of the nervous tissue in control and post-stress states. In HT strain rats (high excitability threshold, low excitable) long-term stressor caused depressive-like behavioral symptoms, increasing of excitability and aggressiveness, while in rats of the LT strain (low excitability threshold, high excitable)-the emergence and preservation of the stereotypical compulsive movements [14]. The genetically determined level of excitability of the nervous system also affects epigenetic milieu that have different dynamics in the brain areas associated with emotions.…”

Section: Introductionmentioning

confidence: 99%

“…Such a characteristic of the nervous system as excitability is of special interest. At the Pavlov Institute of Physiology of Russian Academy of Sciences two strains of rats with contrasting excitability were created as a result of long-term selection [14]. It was shown that rat strains differ in their behavioral responses to stress, and are also characterized by distinct molecular and cytological features of the nervous tissue in control and post-stress states.…”

Section: Introductionmentioning

confidence: 99%

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Effects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system

et al. 2021

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Patients with post-stress pathologies display the signs of inflammation in the peripheral blood as well as in the brain. The mechanisms of such post-stress neuroimmune changes, their contribution to the behavior, the relationship of the intensity of inflammation with genetically determined features have not been clarified. The goal of this work was to evaluate the dynamics of post-stress inflammation in the blood and hippocampus of rats which differ in level of excitability of the nervous system. Rats of two strains (high/low excitability threshold) were subjected to stress according to the K. Hecht protocol and their behavior, neutrophil:lymphocyte ratio and the number of Iba+ cells in the hippocampus were analysed 24 hours, 7 and 24 days after stress exposure. Highly excitable animals show an increase in anxiety-like behavior, in the number of neutrophils compared to lymphocytes as well as in the number of Iba1+ cells in CA1, CA3 and DG areas of the hippocampus in response to stress. Thus, hereditary high excitability of the nervous system is a possible risk factor for the development of post-stress pathologies.

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“…Since the 10th generation, breeding has reached a plateau. At the same time, the 4-fold differences between the strains significantly exceeded the intrastrain variability [14].…”

Section: Animals and Stress Protocolmentioning

confidence: 90%

Section: Animals and Stress Protocolmentioning

confidence: 99%

Section: Animals and Stress Protocolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system

et al. 2021

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The Effect of Long-Term Emotional and Painful Stress on the Expression of Proinflammatory Cytokine Genes in Rats with High and Low Excitability of the Nervous System

Shalaginova

Tuchina

Turkin

et al. 2023

J Evol Biochem Phys

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Stress plays an important role in the pathogenesis of anxiety and depressive disorders. Neuroinflammation is considered as one of the mechanisms by which stress alters the molecular and cellular plasticity in the nervous tissue and thus entails CNS dysfunction. The contribution of genetically determined features of the nervous system to the development of post-stress neuroinflammation has not been sufficiently studied. In this study, the dynamics of post-stress changes in mRNA levels of the il-1 β and tnf genes encoding proinflammatory cytokines interleukin-1 beta (IL-1β) and tumor necrosis factor (TNF) were evaluated in the blood and brain of two rat strains with high and low excitability thresholds of the nervous system (HT and LT, respectively). Changes in IL-1β and TNF mRNA levels were assessed by real-time PCR 24 h, 7, 24 and 60 days after long-term long-term emotional and painful stress in the blood and three brain structures involved in the development of post-stress pathology (prefrontal cortex, hippocampus, amygdala). In highly excitable LT rats, IL-1β mRNA level in the hippocampus and amygdala increased compared to the control 24 days after stress termination, while in low-excitable HT animals, an increase in the level of IL-1β mRNA was only detected in the hippocampus at the same time point. TNF mRNA level did not change in any of the rat strains at any of the post-stress time points. Genetically determined excitability of the nervous system is a promising marker of individual stress vulnerability, as manifested in post-stress disorders associated with developmental and time-course features of neuroinflammation.

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Hereditary determined diving behaviour in rats as a factor of fitness

Levina

Сергеевна²,

Бондаренко³

et al. 2020

Ecological genetics

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Background. Rats natural ability to swim and dive provides adaptation in the wildlife and is widely applied as an instrument in experimental physiology. Nevertheless theres little scientific evidence on diving behaviour in rats itself. Meanwhile this behavioural pattern might be a notable trait to shed light on functional features of the nervous system, the higher nervous activity structure and evolutional adaptability in animals, including inherited ones. Materials and methods. In the present work we compared the performance of the spontaneous diving behaviour in the Morris water maze and forced diving behaviour in the Extrapolation escape task in two selected rat strains genetically differing in the nervous system excitability threshold. Results. We found a greater extent and adaptive pattern of both types of the diving behaviour in the high-excitable LT strain. This may be due to such basic features of this strain as high exploratory activity and an increased level of fear reactions. It was also shown that the second, low-excitable HT rat strain, demonstrates maladaptive jumping behaviour in the Extrapolation escape task due to higher anxiety level in the stress conditions. Conclusion. Observed differences between two strains allow us to consider the diving behaviour performed by high-excitable rats an inherited strain characteristic resembling adaptive rat behaviours in the wild and look forward to investigate its genetic mechanisms.

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Selected Rat Strains Ht, Lt As A Model For The Study Of Dysadaptation States Dependent On The Level Of Excitability Of The Nervous System

Cited by 9 publications

References 1 publication

Effects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system

Effects of psychogenic stress on some peripheral and central inflammatory markers in rats with the different level of excitability of the nervous system

The Effect of Long-Term Emotional and Painful Stress on the Expression of Proinflammatory Cytokine Genes in Rats with High and Low Excitability of the Nervous System

Hereditary determined diving behaviour in rats as a factor of fitness

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