Selected molecular and physiological aspects of mammalian ovarian granulosa cells in primary culture

Kranc, Wiesława; Chachuła, Adrian; Bryja, Artur; Ciesiółka, Sylwia; Budna, Joanna; Wojtanowicz-Markiewicz, Katarzyna; Sumelka, Ewa; Borys, Sylwia; Antosik, Paweł; Bukowska, Dorota; Bruska, M; Nowicki, Michał; Kempisty, Bartosz

doi:10.21521/mw.5606

Cited by 11 publications

(16 citation statements)

References 43 publications

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“…Gonadotropin hormones, secreted from the pituitary, such as follicle stimulating hormone (FSH) and luteinizing hormone (LH) interact with receptors localized in the granulosa cells surrounding the oocyte, and thecal cells [19]. Research by Erickson et al showed that the growth of primary follicles is controlled mainly by local growth factors and proceeds independently of the level of hormones secreted from the pituitary gland [20].…”

Section: Physiological Basis Of Folliculogenesis In Mammalsmentioning

confidence: 99%

“…The control of granulosa cell function by the oocyte takes place on the basis of feedback between both cell types. The gamete-somatic cell relation affects both the development of oocyte and ovarian follicles [19], [32].…”

Section: Factors Influencing Follicular Steroidogenesismentioning

confidence: 99%

“…Transcription regulators that play an important role in the formation of antral follicles in the process of folliculogenesis include: Foxo3, Foxl2, Figla, Lhx8, Nobox, Sohlh1 and Sohlh2. In the case of mutation in any of these genes occurs, they can cause ovarian failure, and ultimately infertility in mammals [19].…”

Section: Factors Influencing Follicular Steroidogenesismentioning

confidence: 99%

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Characteristic of factors influencing the proper course of folliculogenesis in mammals

Rybska

Knap

Jankowski

et al. 2018

Medical Journal of Cell Biology

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Folliculogenesis is the process of ovarian follicle formation,, taking presence during foetal period. During the follicular development, oogoniums undergo meiosis and oocytes are formed. In the ovaries of new born sows, primary and secondary follicles are present and, 90 days after birth, tertiary follicles appear. During development in the ovarian follicles growth of granulosa cells and differentiation of the thecal cells can be observed. A cavity filled with follicular fluid appears. Granulosa cells are divided into: mural cells and corona radiata, which together with the oocyte form the cumulus oophorus. Corona radiata cells, mural layers and oolemma contact each other by a network of gap junctions. Secreted from the pituitary gland, FSH and LH gonadotropin hormones act on receptors located in granular and follicular cells. In the postnatal life tertiary follicles and Graafian follicles are formed. When the follicle reaches a diameter of 1 mm, further growth depends on the secretion of gonadotropins. Mature ovarian follicles produce: progestins, androgens and oestrogens. The growth, differentiation and steroidogenic activity of ovarian follicles, in addition to FSH and LH, is also affected by prolactin, oxytocin, steroid and protein hormones, numerous proteins from the cytokine and interleukin family, metabolic hormones like insulin, glucocorticoids, leptin, thyroid hormones and growth hormones. Despite numerous studies, many processes related to folliculogenesis have not been discovered Learning the mechanisms regulating reproductive processes would allow to easily distinguish pathological processes and discover more and more genes and mechanisms of their expression in cells that build ovarian follicles. Running title: regulation of folliculogenesis

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Section: Physiological Basis Of Folliculogenesis In Mammalsmentioning

confidence: 99%

Section: Factors Influencing Follicular Steroidogenesismentioning

confidence: 99%

Section: Factors Influencing Follicular Steroidogenesismentioning

confidence: 99%

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Characteristic of factors influencing the proper course of folliculogenesis in mammals

Rybska

Knap

Jankowski

et al. 2018

Medical Journal of Cell Biology

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“…Alongside GCs are theca cells, ovarian surface epithelial (OSE) cells, and oocytes. Together, the Graafian follicle will form to protect the oocyte (folliculogenesis) and germ cells also mature into an egg (oogenesis) [2,3]. Granulosa cells have small cell-secreted vesicles called exosomes which are essential in mediating communication between cells, and they share this role with gap junctions [4].…”

Section: Introductionmentioning

confidence: 99%

Ovarian follicular cells - living in the shadow of stemness cellular competence

Moncrieff

Mozdziak

Ješeta

et al. 2019

Medical Journal of Cell Biology

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Granulosa cells (GCs) are a major component found in ovarian follicular fluid among oocytes, theca cells, and ovarian surface epithelial (OSE) cells. GCs are steroidogenic and have morphological functions that are important for the development of the follicular follicle. The follicle protects the developing female egg. GCs are also essential for the maturation of the female germ cell. Stem cell properties have been found in luteinised GCs and in vivo cultures have the potential to differentiate to become cells found outside of the ovary. Both three-dimensional (3D) culturing and mouse embryonic fibroblast (MEF) medium have been used to help improve the culturing lifespan of GCs so that their profound proliferation and differentiation capabilities can be studied. Small RNAs called MicroRNAs (miRNAs) are released from exosomes originating from GCs, and they are involved in transforming growth factor (TGF)-β signalling, follicle-stimulating hormone, hormone-related miRNAs, and apoptosis-related pathway. Finding the miRNAs involved in these pathways, and the mechanisms controlling GCs are important to treating conditions like polycystic ovary syndrome (PCOS), and creating new drug therapies. Besides GCs, ovarian stem cells (OSCs) were discovered in the OSE, and they are believed to be derived from very small embryonic stem cells (VSELs). Transplanting blood mononuclear cells, cell Hormone Therapy (cHT) with bone marrow stem cell supplement and increasing vitamin C levels are all therapies currently being researched into that involve GCs to combat the effects of aging and infertility.Running title: Stemness of ovarian follicular cells

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“…Развитие фолликулов стимулирует рост стромально-сосудистого компонента органа. Она, в свою очередь, выполняя опорную и трофическую функцию, обеспечивает дифференциацию и сохранение пула половых клеток [5,17]. Развитие мозгового вещества также направлено на выполнение трофической функции.…”

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The Effect Gestation Course on Embryogenesis of Ovaries in Cattle

Skovorodin¹

2019

VESTNIK BSAU

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3. Лобанов Сергей Александрович, доктор медицинских наук, профессор, кафедра охраны здоровья и БЖД, ФГБОУ ВО «БГПУ им. М. Акмуллы», 450008, Республика Башкортостан, г. Уфа, ул. Октябрьской революции, 3А, e-mail: lobanovprof@yandex.ru.Статья раскрывает некоторые особенности, происходящие в мозжечке крыс при кровопотере. В результате экспериментальных исследований уже в первые часы после острой кровопо-тери выявлены изменения со стороны микроциркуляторного русла. Приведены данные изменения содержания разных классов гликозаминогликанов.A. Rozhentsev, M. Rozhentsev, S. Lobanov MORPHOLOGICAL AND FUNCTIONAL CHANGES OF RAT CEREBELLUM AT BLOOD LOSS Authors' personal details1. Rozhentsev Alexey, first year Post-graduate student of the Health protection and life safety department, Bashkir State Pedagogical University named after M. Akmulla, 450008, Republic of Bashkortostan, Ufa, Oktyabrskaya Revolutsia st., 3A, e-mail: ufa.darts@yandex.ru. 2. Rozhentsev Mikhail, first year Post-graduate student of the Health protection and life safety department, Bashkir State Pedagogical University named after M. Akmulla, 450008, Republic of Bashkortostan,The paper reveals some features that occur in the cerebellum of rats at blood loss. As the result of experimental studies in the first hours after acute blood loss there are changes in the microcirculatory bloodstream. There are changes in the content of different classes of glycosaminoglycans. ВЛИЯНИЕ ТЕЧЕНИЯ БЕРЕМЕННОСТИ НА ЭМБРИОГЕНЕЗ ЯИЧНИКОВ КРУПНОГО РОГАТОГО СКОТА Ключевые слова: эмбриональное развитие; яичники плода; морфогенез яичников; коровы; патология обмена веществ.Введение. Ущерб от бесплодия крупного рогатого скота очень значителен. В США и ряде стран Западной Европы ежегодный уровень выбраковки коров достигает 34 % в основном за счет длительного бесплодия [37]. Восполнить эти потери можно лишь интенсивным вводом в маточное стадо первотелок. Этот процесс сдерживают следующие факторы. Во-первых, у них гораздо чаще, чем у полновозрастных коров, возникают проблемы с оплодотворением. Вовторых, в сельхозпредприятиях Российской Федерации наступление половой и физиологической зрелости у телок нередко задерживается на срок от шести до двенадцати месяцев [38], а при позднем вступлении телок в пору продуктивной жизни потребность в них возрастает до 50 % от числа основного стада, что является следствием не только скудного кормления растущих живот- E. Skovorodin THE EFFECT GESTATION COURSE ON EMBRYOGENESIS OF OVARIES IN CATTLE

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Selected molecular and physiological aspects of mammalian ovarian granulosa cells in primary culture

Cited by 11 publications

References 43 publications

Characteristic of factors influencing the proper course of folliculogenesis in mammals

Characteristic of factors influencing the proper course of folliculogenesis in mammals

Ovarian follicular cells - living in the shadow of stemness cellular competence

The Effect Gestation Course on Embryogenesis of Ovaries in Cattle

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