Selected drugs in solid matrices: a review of environmental determination, occurrence and properties of principal substances

Beausse, Johanne

doi:10.1016/j.trac.2004.08.005

Cited by 189 publications

(85 citation statements)

References 44 publications

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“…pdf; checked on May 2005). The most prevalent antibiotics found in the environment have been macrolide, fluoroquinolone, and sulfonamide groups [27]. Although tetracyclines or penicillins have been found only in some cases and generally at low concentrations, the two applications found in the literature in the period of time reviewed in this work are focused on the determination of these antibiotics in water samples.…”

Section: Antibiotics In Environmental Samples: Their Role As Emergingmentioning

confidence: 99%

Recent advances in the analysis of antibiotics by capillary electrophoresis

García-Ruiz

Marina

2006

Electrophoresis

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Recent advances in the analysis of antibiotics by capillary electrophoresisIn this review, the main aspects related to the separation of different groups of antibiotics by CE as well as the different applications reported in the literature from the beginning 2003 till May 2005 will be provided to the readers. Firstly, the experimental conditions employed to achieve the analysis of antibiotics by CE are given. Then, the main applications performed in the pharmaceutical, clinical, food, and environmental fields have been reviewed making emphasis on sample preparation requirements needed in each case. Finally, the main conclusions and future prospects in this field are presented. Although HPLC is mainly used for the analysis of antibiotics by separation techniques, CE is being increasingly employed due to its favorable characteristics (high efficiency, large flexibility, and low consumption of samples and reagents). In addition, CE is being used in routine analysis because it allows obtaining appropriate analytical characteristics and good quantitative results. The analysis of antibiotics by CE is mainly included in two different working modes: (i) CZE where a separation buffer without or with additives is used for the separation of ionic or ionogenic antibiotics based on their different electrophoretic mobilities, and (ii) MEKC where a micellar system (surfactant at a concentration higher than its CMC) is added to the separation buffer to perform the separation of neutral and/or ionic or ionogenic antibiotics based on the generation of a pseudostationary phase in which analyte partition takes place. Although much less used, CEC and nonaqueous CE (NACE) have also been used for the analysis of antibiotics [2]. KeywordsIn order to provide to the readers an updated view of the separation conditions as well as the different applications reported in the analysis of antibiotics using CE as separation technique, this review covers the literature dealing on the analysis of antibiotics by CE from the beginning of 2003 till May 2005. Literature published before this date on this subject has already been reviewed by Flurer [2][3][4][5]. The experimental conditions employed to achieve the analysis of antibiotics by CE are first presented in this article. Section 3 of this work describes the main applications performed in the pharmaceutical, clinical, food, and environmental fields making emphasis on sample preparation requirements needed in each case. Finally, the main conclusions and future prospects in this field are presented. Analysis of antibiotics by CE

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Section: Antibiotics In Environmental Samples: Their Role As Emergingmentioning

confidence: 99%

Recent advances in the analysis of antibiotics by capillary electrophoresis

García-Ruiz

Marina

2006

Electrophoresis

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“…For example, some fibrate drugs hydrolyze to clofibric acid and fenofibric acid at pH 2 [19], and tetracyclines may undergo epimerization [11]. Furthermore, pH adjustment should be carried out after filtration in order to avoid possible losses during filtration due to the increase in the analyte hydrophobicity.…”

Section: 2mentioning

confidence: 99%

“…Additionally, reviews have appeared recently on the determination of pharmaceuticals [11,12], surfactants, and their metabolites [1,2] in environmental solid samples.…”

Section: Solid Samplesmentioning

confidence: 99%

“…An example of this is the determination of basic psychiatric pharmaceuticals in wastewater by acetylation-SPME followed by GC-MS determination, where detection limits ranging between 15 and 75 ng L -1 for 10 mL sample volumes were obtained [85]. Another example is the determination of 18 aromatic primary amines, 11 which were converted into their iodo-derivatives in a two-step process, further extracted by SPME, and then analyzed by GC-MS [86]. The substitution of the amine by an iodine group not only reduced the polarity of the amines, but also increased the mass of the analytes by 111 amu (atomic mass units).…”

Section: Microextractionsmentioning

confidence: 99%

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Analytical Methods for Polar Pollutants

Reemtsma

Quintana

2006

Organic Pollutants in the Water Cycle

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“…The benefits of their use are obvious, but their abusing use leads to the accumulation of residues in different environmental sections and an increased risk for growth and promotion of bacterial resistance (Pico´ and Andreu, 2007;Beausse, 2004;Karthikeyan and Meyer, 2006). Furthermore, their wastes are potentially persistent and can be found in fish and water (Beausse, 2004;Karthikeyan and Meyer, 2006;Dı´az-Cruz et al, 2003). The first measure to avoid this scenario is to prevent drug spread by having a strict control of the applied doses.…”

Section: Introductionmentioning

confidence: 99%

Novel optical PVC probes for on-site detection/determination of fluoroquinolones in a solid/liquid interface: Application to the determination of Norfloxacin in aquaculture water

Silva

Moreira

Truta

et al. 2012

Biosensors and Bioelectronics

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A novel optical disposable probe for screening fluoroquinolones in fish farming waters is presented, having Norfloxacin (NFX) as target compound. The colorimetric reaction takes place in the solid/liquid interface consisting of a plasticized PVC layer carrying the colorimetric reagent and the sample solution. NFX solutions dropped on top of this solid-sensory surface provided a colour change from light yellow to dark orange.Several metals were tested as colorimetric reagents and Fe(III) was selected. The main parameters affecting the obtained colour were assessed and optimised in both liquid and solid phases. The corresponding studies were conducted by visible spectrophotometry and digital image acquisition. The three coordinates of the HSL model system of the collected image (Hue, Saturation and Lightness) were obtained by simple image management (enabled in any computer).The analytical response of the optimised solid-state optical probe against concentration was tested for several mathematical transformations of the colour coordinates. Linear behaviour was observed for logarithm NFX concentration against Hue þ Lightness. Under this condition, the sensor exhibited a limit of detection below 50 mM (corresponding to about 16 mg/mL). Visual inspection also enabled semi-quantitative information. The selectivity was ensured against drugs from other chemical groups than fluoroquinolones.Finally, similar procedure was used to prepare an array of sensors for NFX, consisting on different metal species. Cu(II), Mn(II) and aluminon were selected for this purpose. The sensor array was used to detect NFX in aquaculture water, without any prior sample manipulation.

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Selected drugs in solid matrices: a review of environmental determination, occurrence and properties of principal substances

Cited by 189 publications

References 44 publications

Recent advances in the analysis of antibiotics by capillary electrophoresis

Recent advances in the analysis of antibiotics by capillary electrophoresis

Analytical Methods for Polar Pollutants

Novel optical PVC probes for on-site detection/determination of fluoroquinolones in a solid/liquid interface: Application to the determination of Norfloxacin in aquaculture water

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