Selected blood parameters altered by different doses of pesticide Malathion in albino rat (Rattus-norvegicus)

Sharma, C. D.; Shukla, Neha; Bansal, G. L.

doi:10.36953/ecj.2020.21311

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…Additionally, WBCs and neutrophils increased in the SFX-intoxicated group, while lymphocytes, eosinophils, monocytes, and basophils decreased. These results are consistent with the findings of (Sharma et al, 2020), who reported that while WBC count increased after a single dosage of chlorpyrifos, RBCs, hemoglobin, and decreased.…”

Section: Discussionsupporting

confidence: 92%

Investigation the Acute Effects of Sulfoxaflor Insecticide on Hematological and Immunological Parameters in Male Albino Rat Rattus Norvegicus

amar,

youssif,

said

et al. 2024

Menoufia Journal of Plant Protection

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Sulfoxaflor (SFX), classified as a sulfoximine insecticide, has been widely utilized on a global scale, leading to permanent human exposure. The study objective was to evaluate the potential hematological and immunological alterations induced by acute toxicity of SFX insecticide in male wistar rats. To attain these objectives, twenty male rats were randomly divided into two equal groups; the 1st group was used as a control group; the other group was exposed 1100 mg/kg body weight SFX by oral gavage for 48 hours, following by 30-day recovery period. Relative liver, thymus, and spleen weights, complete blood count and histological analysis of the thymus, liver, spleen, and Peyer patches were investigated. The results showed that SFX exposure resulted in a considerable reduction in RBCs, hemoglobin, HCT, and platelets following exposure to SFX for 48 hours. However, WBCs and neutrophils increased in the SFX-intoxicated group, while lymphocytes, eosinophils, monocytes, and basophils decreased. Following a 30-day recovery period, there was a notable decrease in WBCs and neutrophils, while the number of RBCs, platelets, and hemoglobin levels increased. Histopathological examination of the thymus, liver, spleen, and Peyer patches indicated that SFX induced only a minor disruption. Nevertheless, the architecture of the bone marrow and lymph nodes was highly structured. Our data showed that the SFX's acute toxicity resulted in hemotoxic and immunotoxic alterations that were recoverable following a time of recuperation.

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Section: Discussionsupporting

confidence: 92%

Investigation the Acute Effects of Sulfoxaflor Insecticide on Hematological and Immunological Parameters in Male Albino Rat Rattus Norvegicus

amar,

youssif,

said

et al. 2024

Menoufia Journal of Plant Protection

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“…PCV readings are important in determining the effect of pesticides and in determining the oxygen-carrying capacity of the blood. Previous studies [ 14 , 19 – 24 ] found a similar decrease in TEC and Hb in malathion and nitrobenzene-exposed animal models.…”

Section: Discussionsupporting

confidence: 66%

Assessing the health hazard originated via pesticide chemicals in human through rabbit model in agricultural production system in Bangladesh

Shaikat

Khan

Imtiaz

et al. 2022

BMC Pharmacol Toxicol

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Background The use of chemical pesticides in developing countries like Bangladesh and their impacts on human health and food security is a global concern. Bangladesh is an agricultural dependent country for the growing population demand for food security and food safety. We conduct this study to assess public health threats of commonly utilised pesticides including malathion and nitrobenzene in female rabbit model. Methods Thirty New Zealand White healthy rabbit was divided randomly into three groups; and subjected to distilled water as control, malathion@ 5 mg/kg body weight and nitrobenzene@ 5 mg/kg body i.p daily for the next 15 days. Hematology, serum biochemistry and hormonal assay were performed. Results Red blood cell (RBC) concentrations (TEC, Hb, PCV%) were reduced in rabbits exposed to malathion and nitrobenzene. The neutrophil and eosinophil percentage were increased in the malathion and nitrobenzene exposed juvenile rabbit group. We found that serum aspartate aminotransferase (AST) and creatinine were increased in the nitrobenzene exposed group in infants, whereas malathion exposure increased serum alanine aminotransferase (ALT). In contrast, the juvenile group exposed to malathion increased the ALT level. There was no change in AST or creatinine levels in juvenile rabbits exposed to malathion or nitrobenzene. Serum estradiol levels were significantly lower in rabbits exposed to malathion and nitrobenzene. Serum testosterone concentration was increased in juvenile rabbits exposed to malathion and nitrobenzene, but progesterone was decreased in malathion exposed juvenile rabbits. Conclusion However, this study highlights the importance of rigorous monitoring and testing of agricultural products. In addition, strengthen research and extension in the fields of agro economy, organic farming, local universities and farmer associations.

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Selected blood parameters altered by different doses of pesticide Malathion in albino rat (Rattus-norvegicus)

Cited by 2 publications

References 16 publications

Investigation the Acute Effects of Sulfoxaflor Insecticide on Hematological and Immunological Parameters in Male Albino Rat Rattus Norvegicus

Investigation the Acute Effects of Sulfoxaflor Insecticide on Hematological and Immunological Parameters in Male Albino Rat Rattus Norvegicus

Assessing the health hazard originated via pesticide chemicals in human through rabbit model in agricultural production system in Bangladesh

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