Selected adipokines and thickness  of the intima-media complex in patients  with systemic lupus erythematosus

Hrycek, Eugeniusz; Banasiewicz-Szkróbka, Iwona; Żurakowski, Aleksander; Dworak, Justyna; Błaszczak, Edward; Franek, Andrzej

doi:10.5603/kp.2018.0099

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…The polarizing macrophages response is one of a non physiological adipose tissue micro environmental hallmarks, favoring an M1 phenotype, where there is a prevalence for the attention of free fatty acids via Toll-like receptors (TLR4 and TLR2) and a pro-inflammatory cytokine reaction (Th1) mediated by using of NF-κB, chemokine secretion, activation of T and B cells and activating an unfolded protein reaction via endoplasmic reticulum stress (Kratz et al, 2014). There are various researches that emphasized the role of leptin in chronic inflammatory process such as metabolic syndrome, obesity and diabetes to title a few, and it has developed as an open secret its participation in autoimmune rheumatic illnesses such as behcet's illness (Hrycek et al, 2018). Leptin possibly acts as a survival protein for neutrophils.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Serum NF-κB, IL-6, IL-8 and their Relation to Leptin in Patients with Active Behcet’s Disease

Marei

Khattab

2021

Egypt. J. Rad.Sci.

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B EHCET'S DISEASE (BD) is a chronic systemic inflammatory autoimmune disease of unknown cause. It is characterized by elevated levels of proinflammatory cytokines that have been previously reported, yet the pathogenesis is still unknown.Nuclear factor kappa B (NF-κB) is a transcription factor that remain latent in the cytoplasm and shuttles to the nucleus whenever activated. On activation, NF-κB regulates the enzymes cytokines (IL-6, IL-8). NF-κB has been contributing to a wide variety of autoimmune diseases amongst which is BD. NF-κB pathways were involved in the anti-apoptotic activity of leptin in neutrophils in vitro. The present study was conducted to determine serum NF-κB levels, and its role in modulating the expression of different cytokines (IL-6, IL-8) in active BD patients. This is in addition to studying the relationship of leptin with NF-κB, IL-6 and IL-8.The current study included 25 patients with active BD and 25 healthy controls. Serum IL-6, IL-8 and NF-κB levels were measured with quantitative sandwich ELISA kit enzyme-linked immunosorbent assay (ELISA) method, while leptin serum levels were measured using specific radioimmunoassay (RIA) kits.IL-6, IL-8, NF-κB and leptin were significantly higher in BD group than in the control group. Also, there was a positive correlation between IL-8, IL-6, NF-κB and leptin. New insights of the role of leptin in the autoimmune pathophysiology was studied, and its relationship with NF-κB, IL-6 and IL-8 in these patients was detected and might help in elucidation of its pathogenesis. Further studies, are required to encourage the use of anti-NF-κB and anti-Leptin as recent treatment modalities in BD.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Serum NF-κB, IL-6, IL-8 and their Relation to Leptin in Patients with Active Behcet’s Disease

Marei

Khattab

2021

Egypt. J. Rad.Sci.

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“…There are several studies that highlighted the role of leptin in chronic inflammatory processes such as obesity, diabetes, and metabolic syndrome to name a few, and it has become an open secret its participation in autoimmune rheumatic diseases. However, its recognition as a possible key biomarker in immunopathogenic mechanisms of diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and ankylosing spondylitis (AS) has been delayed [8][9][10]. Nowadays, we are able to talk about leptin network microenvironments, depending on the target tissue, for example, adipose tissue in obesity, synovial tissue in RA, renal tissue in SLE, and bone tissue in AS.…”

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confidence: 99%

Leptin as an open secret in the physiopathology of rheumatic diseases

Mercado

Martínez-García

2020

Clin Rheumatol

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Adiponectin Deregulation in Systemic Autoimmune Rheumatic Diseases

Brezovec

Perdan-Pirkmajer

Čučnik

et al. 2021

IJMS

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Deregulation of adiponectin is found in systemic autoimmune rheumatic diseases (SARDs). Its expression is downregulated by various inflammatory mediators, but paradoxically, elevated serum levels are present in SARDs with high inflammatory components, such as rheumatoid arthritis and systemic lupus erythematosus. Circulating adiponectin is positively associated with radiographic progression in rheumatoid arthritis as well as with cardiovascular risks and lupus nephritis in systemic lupus erythematosus. However, in SARDs with less prominent inflammation, such as systemic sclerosis, adiponectin levels are low and correlate negatively with disease activity. Regulators of adiponectin gene expression (PPAR-γ, Id3, ATF3, and SIRT1) and inflammatory cytokines (interleukin 6 and tumor necrosis factor α) are differentially expressed in SARDs and could therefore influence total adiponectin levels. In addition, anti-inflammatory therapy could also have an impact, as tocilizumab treatment is associated with increased serum adiponectin. However, anti-tumor necrosis factor α treatment does not seem to affect its levels. Our review provides an overview of studies on adiponectin levels in the bloodstream and other biological samples from SARD patients and presents some possible explanations why adiponectin is deregulated in the context of therapy and gene regulation.

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Selected adipokines and thickness of the intima-media complex in patients with systemic lupus erythematosus

Cited by 3 publications

References 8 publications

Evaluation of Serum NF-κB, IL-6, IL-8 and their Relation to Leptin in Patients with Active Behcet’s Disease

Evaluation of Serum NF-κB, IL-6, IL-8 and their Relation to Leptin in Patients with Active Behcet’s Disease

Leptin as an open secret in the physiopathology of rheumatic diseases

Adiponectin Deregulation in Systemic Autoimmune Rheumatic Diseases

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