Selaginella tamariscina extract suppresses TPA-induced invasion and metastasis through inhibition of MMP-9 in human nasopharyngeal carcinoma HONE-1 cells

Hsin, Chung‐Han; Wu, Buor-Chang; Chuang, Chun‐Yi; Yang, Shun‐Fa; Hsieh, Yi‐Hsien; Ho, Hsin‐Yu; Lin, Huang-Pin; Chen, Mu‐Kuan; Lin, Chiao‐Wen

doi:10.1186/1472-6882-13-234

Cited by 25 publications

(20 citation statements)

References 41 publications

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“…Other innovative therapeutic approaches, such as targeted anticancer treatment with biological antibodies or newly identified naturally occurring chemicals, are needed to improve treatment outcomes. A large body of experimental evidence shows that herbal medicines are beneficial in the treatment of cancers (Newman et al, 2002), including our previous study on the antimetastatic effect of Selaginella tamariscina extract on NPC cells (Hsin et al, 2013). Recently, P. linteus has been reported to be a promising candidate as an alternative anticancer agent that acts synergistically with existing antitumor drugs (Zhu et al, 2008).…”

Section: Discussionmentioning

confidence: 97%

Hispolon suppresses migration and invasion of human nasopharyngeal carcinoma cells by inhibiting the urokinase‐plasminogen activator through modulation of the Akt signaling pathway

Hsieh

et al. 2016

Environmental Toxicology

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Hispolon has been reported to possess antioxidant, antiinflammatory, and antitumor activities. However, the effect of hispolon on the metastasis of nasopharyngeal carcinoma (NPC) remains unclear. In this study, we investigated how the antimetastatic activity and relevant signaling pathways of hispolon affected three NPC cell lines. The results revealed that hispolon significantly reduced the migration and invasion of three NPC cells in a dose-dependent manner from 0 to 50 µM. Hispolon also significantly inhibited the activity and expression of urokinase-plasminogen activator (uPA) as well as the phosphorylation of Akt. Moreover, blocking the Akt pathway also enhanced the antimetastatic ability of hispolon in the NPC cells. In conclusion, hispolon inhibited uPA expression and NPC cell metastasis by downregulating Akt signal pathways; therefore, hispolon exerts beneficial effects in chemoprevention. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 645-655, 2017.

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Section: Discussionmentioning

confidence: 97%

Hispolon suppresses migration and invasion of human nasopharyngeal carcinoma cells by inhibiting the urokinase‐plasminogen activator through modulation of the Akt signaling pathway

Hsieh

et al. 2016

Environmental Toxicology

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“…This study revealed that TCE suppressed TPA‐induced invasion and metastasis through the inhibition of MMP‐9 and ERK1/2 phosphorylation in human cervical cancer cells. TPA, is a small molecule drug, as a tumor‐promoting agent in various cancer cell lines . However, Zhu et al reported that TPA has been established as an anti‐tumorigenic drug in liver cancer cells.…”

Section: Discussionmentioning

confidence: 99%

“…According to the manufacturer's instructions, 2 μg of RNA was reverse‐transcribed into cDNA using the SuperScript III First‐Strand Synthesis Supermix kit (Invitrogen, Carlsbad, California). The mRNA levels of MMP‐9 were examined through reverse transcription‐polymerase chain reaction (RT‐PCR) and real‐time PCR as previously described …”

Section: Methodsmentioning

confidence: 99%

Antimetastatic effects of Terminalia catappa leaf extracts on cervical cancer through the inhibition of matrix metalloprotein‐9 and MAPK pathway

Lee

Yang

Wang

et al. 2018

Environmental Toxicology

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The effects of Terminalia catappa leaf extracts (TCE) have been widely investigated, including its antioxidative, anti-inflammatory, and antidiabetic activity, as well as its antimetastatic effects on several types of human cancer. However, no study has examined the antimetastatic potential of TCE in cervical cancer cells. This study aimed to elucidate the potential antimetastatic properties of ethanol extracts of Terminalia catappa in 12-O-tetradecanoylphorbol-13-acetate treated human cervical cancer cells and investigate the signaling pathway of this process. We demonstrated that TCE elicited very low cytotoxicity and significantly inhibited cellular migration and invasion in human HeLa and SiHa cervical cancer cells. Moreover, the gelatin zymography, reverse transcription-polymerase chain reaction (RT-PCR), and real-time PCR analysis revealed that the activity and mRNA level of matrix metalloproteinase-9 (MMP-9) were inhibited by TCE in a concentration-dependent manner.The Western blot results demonstrated that the highest concentration of TCE (100 μg/ml) reduced the phosphorylation of extracellular signal-regulated kinases 1/2 (ERK1/2) by 46% in the HeLa cell lines. In conclusion, it was revealed that TCE exerted antimetastatic effects on cervical cancer cells by inhibiting the expression of MMP-9 through the ERK1/2 pathway. K E Y W O R D S cervical cancer, MAPK pathway, migration, MMP-9, Terminalia catappa 1 | INTRODUCTION Cervical cancer is one of the leading causes of cancer death and the 4th most frequently occurring malignancy among women worldwide and more than 260 000 women die of cervical cancer annually. 1 Moreover, International Agency for Research on Cancer (IARC) assessed the incidence rate of cervical cancer as 19.0 women per 100 000. 2 Most patients with cervical cancer present with abnormal vaginal bleeding or a cervical mass. 3 Lesion size and pelvic node metastases are vital prognostic factors in cervical cancer. 4 The Chung-Yuan Lee and Shun-Fa Yang contributed equally to the work.

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“…The FAK and Src activation is capable of modulating cell migration and invasion [18, 19, 30]. Our previous study revealed that FAK phosphorylation was involved in caffeic acid phenethyl ester-inhibited oral cancer cell metastasis [21] and WISP1-induced OSCC angiogenesis [31].…”

Section: Discussionmentioning

confidence: 99%

MMP-11 promoted the oral cancer migration and FAK/Src activation

et al. 2017

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Matrix metalloproteinase-11 (MMP-11) has been observed in most invasive human carcinomas. The current study investigated the association between the clinicopathological characteristics and MMP-11 expression in oral squamous cell carcinoma (OSCC) patients. Immunohistochemistry (IHC) staining was performed to assess MMP-11 expression in 279 patients with OSCC. In addition, the metastatic effects of the MMP-11 overexpression on the OSCC cells were also investigated. We found that MMP-11 expression was present in 118/279 (42.3%) cases and expression of MMP-11 was associated with higher incidence of lymph node metastasis and worse grade of tumor differentiation. Importantly, OSCC patients with strong expression of MMP-11 had a significantly lower survival rate (p=0.010). Furthermore, MMP-11 overexpression in OSCC cells increased in vitro cell migration. Mechanistically, MMP-11 increased the cell motility of OSCC cells through focal adhesion kinase/Src kinase (FAK/Src) pathway. In conclusion, our results revealed that the MMP-11 expression in OSCC samples can predict the progression, especially lymph node metastasis, and the survival of OSCC patients in Taiwan.

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Selaginella tamariscina extract suppresses TPA-induced invasion and metastasis through inhibition of MMP-9 in human nasopharyngeal carcinoma HONE-1 cells

Cited by 25 publications

References 41 publications

Hispolon suppresses migration and invasion of human nasopharyngeal carcinoma cells by inhibiting the urokinase‐plasminogen activator through modulation of the Akt signaling pathway

Hispolon suppresses migration and invasion of human nasopharyngeal carcinoma cells by inhibiting the urokinase‐plasminogen activator through modulation of the Akt signaling pathway

Antimetastatic effects of Terminalia catappa leaf extracts on cervical cancer through the inhibition of matrix metalloprotein‐9 and MAPK pathway

MMP-11 promoted the oral cancer migration and FAK/Src activation

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