Seizures following Intoxication with a Common Antituberculosis Drug

Lahlou, Adnane; Benlamkaddem, Said; Berdaï, Mohamed Adnane; Harandou, Mustapha

doi:10.1155/2019/8972574

Cited by 2 publications

(3 citation statements)

References 16 publications

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“…Toxic doses are estimated at 35-40 mg/kg and fatal doses at 150 mg/kg. [3,4] INH has structural similarities to pyridoxine (vitamin B6). The accumulation of INH can lead to a functional deficiency of pyridoxine.…”

Section: Discussionmentioning

confidence: 99%

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Seizures as a Manifestation of Isoniazid Intoxication: A Case Report

Gayatri

2022

Int J Res Rev

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Introduction: Isoniazid (INH) intoxication is a serious health problem that can be life-threatening. Acute intoxication manifests as neurological symptoms such as seizures. Case Illustration: A woman, 27 years old, came to the emergency department with seizures after taking ten tablets (3000 milligrams) of Isoniazid. Laboratory examination showed a severe metabolic acidosis and increased liver function test. The management primarily consists of basic life support, antiseizure, and antidote. Conclusion: Isoniazid toxicity is associated with a high mortality rate. The first signs and symptoms of isoniazid toxicity may appear within 30 minutes to two hours. Acute toxicity of Isoniazid may manifest as neurological symptoms such as seizures. Management of INH intoxication consists of controlling the life-threatening condition, administering an antidote such as pyridoxine, and symptomatic supportive therapy. Keywords: Isoniazid, intoxication, seizures

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Section: Discussionmentioning

confidence: 99%

“…[2] INH intoxication often occurs due to inadvertent consumption, such as in children, suicide attempts, or in patients on medication who intentionally take extra tablets to compensate for being late or forgetting to take their previous medication. [3,4]…”

Section: Introductionmentioning

confidence: 99%

Seizures as a Manifestation of Isoniazid Intoxication: A Case Report

Gayatri

2022

Int J Res Rev

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“…The toxic effect of isoniazid depends on its dose. Toxic doses are estimated at 35-40 mg/kg, while lethal -at 150 mg/kg (Lahlou et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Histological and histochemical changes in the peripheral organs of the immune system of dogs in cases of isoniazid poisoning

Kotsyumbas

Vretsona

2021

Regul. Mech. Biosyst.

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Most publications on isoniazid poisoning in dogs are devoted to clinical diagnostics, treatment, and prevention of the disease. Histological and histochemical changes are not fully described, though they are important in assessing the toxic effects of isoniazid. Isoniazid is used to treat tuberculosis in humans. Dogs are hypersensitive to this drug. The article highlights the results of macroscopic, histological, and histochemical studies of the dogs’ lymph nodes and spleen in cases of isoniazid poisoning. A pathological examination of 19 corpses of dogs of different ages was performed, during which isoniazid poisoning was posthumously diagnosed, based on anamnesis, clinical signs, pathological autopsy, histological, and histochemical examination. Samples of lymph nodes and spleen were fixed in a 10% aqueous neutral formalin solution, Carnoy’s solution, and Bouin’s fixative. Histoсuts were prepared using a sled microtome and stained with hematoxylin and eosin. Staining was also performed according to the techniques suggested by McManus, Brachet, and Perls. The pathomorphological changes in lymph nodes and spleen were characterized by disorganization of vascular walls and connective tissue fibers of the stroma, dilatation of veins, their overflow with hemolyzed blood, and, in cases of the long clinical course, thrombosis of small vessels. Intravascular hemolysis of erythrocytes resulted in an excessive formation of hemosiderin. Histochemically, the spleen and lymph nodes showed a significant increase in the number of hemosiderophages in the spleen’s red and white pulp and the lymph nodes’ central sinuses and pulp cords. In the spleen, mucoid swelling and necrobiotic changes in the wall structures of the arterioles and arteries progressed with a narrowing of their lumen in dogs suffering from the long clinical course. Increased permeability of the microcirculatory tract vessels of the spleen and lymph nodes, transudate formation, and the destructive changes in the reticular skeleton accompanied hemodynamic violations. A sharp change in blood rheology caused the violation of trophism and metabolism in the immune system. Lymphoid elements of the lymph nodes and white pulp of the spleen were in a state of karyorrhexis and karyolysis. The morphological study of the immune system’s peripheral organs suggests that dogs poisoned by isoniazid demonstrate hemodynamic disorders, changes in the physicochemical properties of blood (hemolysis of erythrocytes and thrombosis). This is the basis of trophic disorders, metabolic malfunctions, and the development of dystrophic processes in all structural elements of the spleen and lymph nodes.

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Seizures following Intoxication with a Common Antituberculosis Drug

Cited by 2 publications

References 16 publications

Seizures as a Manifestation of Isoniazid Intoxication: A Case Report

Seizures as a Manifestation of Isoniazid Intoxication: A Case Report

Histological and histochemical changes in the peripheral organs of the immune system of dogs in cases of isoniazid poisoning

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