Seizures after cerebrovascular events: Risk factors and clinical features

Conrad, Julian; Pawlowski, Matthias; Dogan, M.; Kovač, Stjepana; Ritter, Martin; Evers, Stefan

doi:10.1016/j.seizure.2013.01.014

Cited by 110 publications

(116 citation statements)

References 43 publications

(101 reference statements)

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“…We prescribed phenytoin as the first line of AED in acute Neuro ICU setting for patients of stroke with early onset seizure because of the ease of parenteral administration and cost effectiveness, even though more than 50% had partial seizures in one or other form and oxcarbamazepine as an additional drug. Julian et al [17] found that NIHSS score was significantly higher in patients with seizures (7.7 ± 6.1), than in patients without seizures (4.3 ± 4.9). In our study we didn't find any statistical significance in NIHSS score in stroke patients with or without early onset seizures.…”

Section: Discussionmentioning

confidence: 97%

Frequency and Outcomes of Early Onset Seizures after Ischemic Stroke

Natuva¹,

Khaseem²,

Padala³

et al. 2015

J Neurol Exp Neurosci

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Section: Discussionmentioning

confidence: 97%

Frequency and Outcomes of Early Onset Seizures after Ischemic Stroke

Natuva¹,

Khaseem²,

Padala³

et al. 2015

J Neurol Exp Neurosci

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“…Conrad ve ark. [7] 593 hastadan oluşan bir araştırmada çok ciddi inme ve sinüs trombozuna sahip kişilerde epilepsi nöbeti prevalansı %11.6 saptanmıştır. Lezyon lokalizasyonu ise nöbet riskini etkilememişti.…”

Section: Discussionunclassified

“…[7] Ayrıca serebrovasküler hastalığa yol açan konvansiyonel risk faktörlerinin poststrok epilepsi riskiyle ilişkili olmadığı bulunmuştu. [7] Yaptığımız çalışmada ise etkilenen damar alanları incelendi; en fazla medial serebral arter (MCA), ikinci sırada anterior serebral arter (ACA) gelmekteydi. Posterior serebral arter (PCA) alanına ait inme olgusu yoktu.…”

Section: Discussionunclassified

Epilepsy in elderly patients

Halaç¹

2015

Epilepsi

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SummaryObjectives: The incidence of new-onset epilepsy is high among the elderly. This study presents the demographic characteristics, etiological factors, seizure types and response rates to treatment in a group of patients aged 65 years or over with delayed-onset epilepsy. Methods:The study comprised a retrospective evaluation of the records of 43 patients aged 65 or older with a diagnosis of delayed-onset epilepsy who were admitted to the epilepsy clinic in the Neurology Department of Bezmialem University Faculty of Medicine.Results: Patient mean age was 74.9 (66-92 years). Underlying disease was found to be cerebrovascular disease in 37.2%. Based on seizure type, 67.4% (n=29) patients had partial-onset and 32.6% (n=14) had generalized seizure. Treatment protocol in 93% (n=40) of the patients was monotherapy antiepileptic drugs, the most commonly used being levetiracetam (53.5%). Assessment of drug side effects showed no complaint in 86% (n=37) of the patients. During the three months prior to the study, 95.3% of the patients had been seizure free. Conclusion:The study found cerebrovascular disease to be the most common etiological factor in delayed-onset epilepsy. Partial-onset secondary generalized seizure was the most common seizure type. All patients responded well to monotherapy and have a good prognosis.Key words: Epilepsy; treatment; elderly patients. ÖzetAmaç: Yaşlılarda yeni başlangıçlı epilepsi insidansı oldukça yüksektir. Çalışmada, 65 yaş üstü geç başlangıçlı epilepsi tanısı alan hastaların demografik özellikleri, etiyolojik faktörleri, nöbet tipleri ve tedaviye yanıt oranları sunulmuştur ve literatür eşliğinde sonuçlar tartışılmıştır. Sonuç: Geç başlangıçlı epilepsi hastalarında en sık görülen etiyolojik neden serebrovasküler hastalık olup nöbet tipi çoğunlukla parsiyel başlangıçlı sekonder jeneralize tonik kloniktir, hastalar monoterapiye iyi yanıt verir ve prognoz iyi seyirlidir. Gereç ve

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“…Demansta epilepsi insidansı çok değişken oranlarda (%5-64) bildirilmiştir (21). Non-vasküler demans ve Alzheimer hastalığı ilerlediğinde epileptik nöbet geçirme insidansı artmaktadır.…”

Section: Discussionunclassified

Epilepsy in the elderly

Balcı¹,

Mutlu²,

Özer³

et al. 2015

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Amaç: Epilepsi yaşlılarda sık görülen bir hastalıktır, ancak etiyolojisi, klinik sunumu, eşlik eden hastalıkları ve prognozu genç hastalardan farklıdır. Bu çalışmada epilepsi nedenleri, yaşlılarda nöbet tipleri, elektroensefalografi (EEG) bulguları araştırıldı. Gereç ve Yöntem:İlk epileptik nöbetini geçiren ve altmış beş yaş üzerinde 95 hasta retrospektif olarak değerlendirildi. Yaş, epilepsi tipi, EEG bulguları, manyetik rezonans görüntüleme ve/veya kranial tomografi bulguları, etiyoloji, eşlik eden hastalıklar ve verilen antiepileptik tedaviler değerlendirildi. Anah tar Ke li me ler: Epilepsi, nöbet tipi, EEG, tedavi, yaşlı hastalar Objective: Epilepsy is frequently seen in the elderly, but its etiology, clinical presentation, comorbidities, and prognoses are different than younger patients. In this study, we investigated types of seizures, electroencephalography (EEG) findings and the cause of epilepsy in the elderly. Materials and Methods:We retrospectively analyzed 95 patients who were 65 years old or older, and who had an epileptic seizure for the first time. Type of epilepsy, age, EEG findings, magnetic resonance imaging and/or cranial tomography findings, etiology, comorbidities and antiepileptic medication were evaluated. Results:The average age of our patients was 75, and 50 (56%) patients were male. Among 95 patients, 55 (58%) had focal seizures, 36 (38%) had generalized tonic-clonic seizures and 4 (4%) had convulsive status epilepticus. The frequency of focal interictal epileptiform activity was 32.6% patients. Seizures were responsive to treatment administered as monotherapy in 81 (85%) patients and as politherapy in 14 (15%) patients. Our study showed that cerebrovascular disease was the most common (63%) etiological cause identified. There was no significant relationship between age and frequency of seizures and EEG abnormalities. However, a significant correlation was found between age and comorbidities. Conclusion:Our results supported the focal seizure is the most common manifestation of epilepsy in the elderly. Cerebrovascular disease is the most common etiological cause of epilepsy in the elderly. Monotherapy is sufficient in the majority of patients. Continuous growth of the elderly population is increasing the need for accurate diagnosis and effective treatment. (Turkish Journal of Neurology 2015; 21:62-7)

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Seizures after cerebrovascular events: Risk factors and clinical features

Cited by 110 publications

References 43 publications

Frequency and Outcomes of Early Onset Seizures after Ischemic Stroke

Frequency and Outcomes of Early Onset Seizures after Ischemic Stroke

Epilepsy in elderly patients

Epilepsy in the elderly

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