This paper illustrates how an emulator (or meta-model) of a tsunami code can be a useful tool to evaluate or qualify tsunami hazard levels associated with both specific and unknown tsunamigenic seismic sources. The meta-models are statistical tools permitting to drastically reduce the computational time necessary for tsunami simulations. As a consequence they can be used to explore the tsunamigenic potential of a seismic zone, by taking into account an extended set of tsunami scenarios. We illustrate these concepts by studying the tsunamis generated by the Azores-Gibraltar Plate Boundary (AGPB) and potentially impacting the French Atlantic Coast. We first analyze the impact of two realistic scenarios corresponding to potential sources of the 1755-Lisbon tsunami (when uncertainty on seismic parameters is considered). We then show how meta-models could permit to qualify the tsunamis generated by this seismic area. All the results are finally discussed in light of tsunami hazard issued by the TSUMAPS-NEAM research project available online (http://ai2lab.org/tsumapsneam/ interactive-hazard-curve-tool/). From this methodological study, it appears that tsunami hazard issued by TSUMAPS-NEAM research project is envelop, even when compared to all the likely and unlikely tsunami scenarios generated in the AGPB area. Abbreviations: µ, shear modulus; [N(m(x), s 2 (x))], Gaussian process of mean "m(x)" and variance "s 2 (x)"; [M(x)], kriging surrogate; {X,Y}, are the coordinates of the design simulations used for kriging parameters evaluation; C(.), covariance kernel; CEA, commissariat à l'énergie atomique et aux énergies alternatives; D [m], average slip along the rupture surface; DTHA, deterministic tsunami hazard assessment; GSA, global sensitivity analysis; L [m], length of the rupture surface; MCS, maximum credible scenario; MCS_h, tsunami hazard level issued by an exploration of a very wide range of tsunamigenic scenarios; M o , seismic moment; M w , seismic moment magnitude; MSE, mean squared error; PTHA, probabilistic tsunami hazard assessment; R 2 , squared correlation coefficient; RMSE, root mean squared error; UQ, uncertainty quantifications; W [m], width of the rupture surface.