Fault barriers are key structures for studying seismic hazard in regions of intense brittle deformation. The interaction between fault sets affects their seismogenic behavior, if some of them act as barriers. The Granada Basin, in the Betic Cordillera, is a region affected by shallow brittle deformation, as it was the scenario for the recent Granada 2021 seismic sequence. This seismicity presented a swarm behavior at the beginning of the sequence, followed by mainshock‐aftershock features. Geological and gravity data presented here reveal that the basement is affected by two sets of NW‐SE and NE‐SW normal faults and intensely deformed by vertical NW‐SE joints. Improved relocation of the Granada 2021 seismicity reveals a confined chimney‐shape seismicity caused by the activity of a 2 km long NW‐SE normal fault segment. The confinement of the sequence is associated with the NE‐SW fault set acting as a barrier that restricts the rupture area, limiting the maximum magnitude, and favoring the recurrence of events with smaller magnitude. The chimney‐shape of the seismic sequence suggests that the deformation is propagated vertically to the surface, facilitated by preexisting fractures. The shallow extensional deformation during the uplift of the central Betic Cordillera drove the activity of the local structures obliquely to the regional extensional trends, as evidenced by the seismic sequence. This multidisciplinary study improves the knowledge on the origin of the Granada Basin and underlies the important role of preexisting fractures on fault segmentation and seismic propagation, decreasing the seismic potential of this area.