Segregation of myogenic lineages in <i>Drosophila</i> requires Numb

Ruiz, Miguel; Bate, Michael

doi:10.1242/dev.124.23.4857

Cited by 161 publications

(2 citation statements)

References 43 publications

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“…The remaining cells of the cluster become fusion-competent myoblasts, providing mass to the growing muscle by fusing with it. After specification, muscle progenitors undergo a symmetrical division producing two muscle founder cells (FCs), or an asymmetrical division producing either one FC and one adult muscle progenitor (AMP) or one FC and one pericardial progenitor ( Ruiz Gómez and Bate, 1997 ; Carmena et al, 1998 ). FCs seed individual embryonic muscles and express a unique combination of identity transcription factors (iTFs), controlling all muscle characteristics, including muscle size, position, innervation and attachment.…”

Section: Somatic/skeletal Musculaturementioning

confidence: 99%

Hox Proteins in the Regulation of Muscle Development

Poliacikova

Maurel-Zaffran

Graba

et al. 2021

Front. Cell Dev. Biol.

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Hox genes encode evolutionary conserved transcription factors that specify the anterior–posterior axis in all bilaterians. Being well known for their role in patterning ectoderm-derivatives, such as CNS and spinal cord, Hox protein function is also crucial in mesodermal patterning. While well described in the case of the vertebrate skeleton, much less is known about Hox functions in the development of different muscle types. In contrast to vertebrates however, studies in the fruit fly, Drosophila melanogaster, have provided precious insights into the requirement of Hox at multiple stages of the myogenic process. Here, we provide a comprehensive overview of Hox protein function in Drosophila and vertebrate muscle development, with a focus on the molecular mechanisms underlying target gene regulation in this process. Emphasizing a tight ectoderm/mesoderm cross talk for proper locomotion, we discuss shared principles between CNS and muscle lineage specification and the emerging role of Hox in neuromuscular circuit establishment.

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Section: Somatic/skeletal Musculaturementioning

confidence: 99%

Hox Proteins in the Regulation of Muscle Development

Poliacikova

Maurel-Zaffran

Graba

et al. 2021

Front. Cell Dev. Biol.

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“…ribonucleoprotein, and mutants are described to have a small body and various neuroanatomical defects [38,41,42]. numb encodes an inhibitor of Notch signalling, and mutants are flightless (overexpression) and exhibit muscle defects [38,[43][44][45]. Srp54 k encodes a signal recognition particle [38], and unc-13-4A mutations are associated with pain response defects [38,46].…”

Section: Genes Linked To Climbing Abilitymentioning

confidence: 99%

Exercise-induced changes in climbing performance

Watanabe

Riddle

2021

R. Soc. open sci.

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Exercise is recommended to promote health and prevent a range of diseases. However, how exercise precipitates these benefits is unclear, nor do we understand why exercise responses differ so widely between individuals. We investigate how climbing ability in Drosophila melanogaster changes in response to an exercise treatment. We find extensive variation in baseline climbing ability and exercise-induced changes ranging from −13% to +20% in climbing ability. Climbing ability, and its exercise-induced change, is sex- and genotype-dependent. GWASs implicate ‘cell–cell signalling’ genes in the control of climbing ability. We also find that animal activity does not predict climbing ability and that the exercise-induced climbing ability change cannot be predicted from the activity level induced by the exercise treatment. These results provide promising new avenues for further research into the molecular pathways controlling climbing activity and illustrate the complexities involved in trying to predict individual responses to exercise.

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Muscle pattern diversification in Drosophila: the story of imaginal myogenesis

Roy

VijayRaghavan

1999

Bioessays

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There are two phases of somatic muscle formation in Drosophila. During embryonic development, one phase of myogenesis generates larval muscle elements that mediate the relatively simple behavioural repertoire of the larva. During pupal metamorphosis, a diverse pattern of muscle fibres are assembled, and these facilitate the more elaborate behavioural patterns of the adult fly. In this review, we discuss the current status of understanding of the cellular, genetic, and molecular mechanisms of pattern formation during the second phase, imaginal muscle development. We briefly compare aspects of embryonic and adult myogenesis in Drosophila and muscle development in vertebrates and highlight conserved themes and disparities between these diverse myogenic programmes. BioEssays 21:486–498, 1999. © 1999 John Wiley & Sons, Inc.

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Segregation of myogenic lineages in Drosophila requires Numb

Cited by 161 publications

References 43 publications

Hox Proteins in the Regulation of Muscle Development

Hox Proteins in the Regulation of Muscle Development

Exercise-induced changes in climbing performance

Muscle pattern diversification in Drosophila: the story of imaginal myogenesis

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