Hox Proteins in the Regulation of Muscle Development

Poliacikova, Gabriela; Maurel-Zaffran, Corinne; Graba, Yacine; Saurin, Andrew J.

doi:10.3389/fcell.2021.731996

Cited by 11 publications

(10 citation statements)

References 129 publications

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“…In addition, pdm1, a POU family gene, acts as proximal-distal growth of the wing, which has a similar function to Nub [ 35 ]. Moreover, the HOX domain regulates muscle and wing development [ 36 , 37 ], specifying the anterior posterior axis in all bilaterians [ 38 ]. So, this indicates the high expression of NUB genes in the old pupa stage and the day 1 adult flies.…”

Section: Discussionmentioning

confidence: 99%

BdNub Is Essential for Maintaining gut Immunity and Microbiome Homeostasis in Bactrocera dorsalis

Zhang

Yao

et al. 2023

Insects

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Insects face immune challenges posed by invading and indigenous bacteria. They rely on the immune system to clear these microorganisms. However, the immune response can be harmful to the host. Therefore, fine-tuning the immune response to maintain tissue homeostasis is of great importance to the survival of insects. The Nub gene of the OCT/POU family regulates the intestinal IMD pathway. However, the role of the Nub gene in regulating host microbiota remains unstudied. Here, a combination of bioinformatic tools, RNA interference, and qPCR methods were adopted to study BdNub gene function in Bactrocera dorsalis gut immune system. It’s found that BdNubX1, BdNubX2, and antimicrobial peptides (AMPs), including Diptcin (Dpt), Cecropin (Cec), AttcinA (Att A), AttcinB (Att B) and AttcinC (Att C) are significantly up-regulated in Tephritidae fruit fly Bactrocera dorsalis after gut infection. Silencing BdNubX1 leads to down-regulated AMPs expression, while BdNubX2 RNAi leads to increased expression of AMPs. These results indicate that BdNubX1 is a positive regulatory gene of the IMD pathway, while BdNubX2 negatively regulates IMD pathway activity. Further studies also revealed that BdNubX1 and BdNubX2 are associated with gut microbiota composition, possibly through regulation of IMD pathway activity. Our results prove that the Nub gene is evolutionarily conserved and participates in maintaining gut microbiota homeostasis.

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Section: Discussionmentioning

confidence: 99%

BdNub Is Essential for Maintaining gut Immunity and Microbiome Homeostasis in Bactrocera dorsalis

Zhang

Yao

et al. 2023

Insects

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“…We previously reported methylation changes around HOX genes in myonuclei during hypertrophy 91 and with exercise during aging in muscle 78 . HOX genes control muscle development 92,93 , but little is known about their role in RE adaptation in adult skeletal muscle.…”

Section: Changes To the Muscle Dna Methylome At 30 Minutes Of Recover...mentioning

confidence: 99%

The 24-Hour Time Course of Integrated Molecular Responses to Resistance Exercise in Human Skeletal Muscle ImplicatesMYCas a Hypertrophic Regulator That is Sufficient for Growth

Edman,

Jones,

Jannig

et al. 2024

Preprint

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Molecular control of recovery after exercise in muscle is temporally dynamic. A time course of biopsies around resistance exercise (RE) combined with -omics is necessary to better comprehend the molecular contributions of skeletal muscle adaptation in humans. Vastus lateralis biopsies before and 30 minutes, 3-, 8-, and 24-hours after acute RE were collected. A time-point matched biopsy-only group was also included. RNA-sequencing defined the transcriptome while DNA methylomics and computational approaches complemented these data. The post-RE time course revealed: 1) DNA methylome responses at 30 minutes corresponded to upregulated genes at 3 hours, 2) a burst of translation- and transcription-initiation factor-coding transcripts occurred between 3 and 8 hours, 3) global gene expression peaked at 8 hours, 4) ribosome-related genes dominated the mRNA landscape between 8 and 24 hours, 5) methylation-regulated MYC was a highly influential transcription factor throughout the 24-hour recovery and played a primary role in ribosome-related mRNA levels between 8 and 24 hours. The influence of MYC in human muscle adaptation was strengthened by transcriptome information from acute MYC overexpression in mouse muscle. To test whether MYC was sufficient for hypertrophy, we generated a muscle fiber-specific doxycycline inducible model of pulsatile MYC induction. Periodic 48-hour pulses of MYC over 4 weeks resulted in higher muscle mass and fiber size in the soleus of adult female mice. Collectively, we present a temporally resolved resource for understanding molecular adaptations to RE in muscle and reveal MYC as a regulator of RE-induced mRNA levels and hypertrophy.

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“…As development progresses, the Antp expression pattern is refined to regulate gene expression in the three germ layers of mesothoracic tissues, which will develop into the cuticle, muscles, and nerves of the mesothorax, wings, and the second pair of legs. Antennapedia and other Hox proteins are crucial for embryonic muscle development (Poliacikova et al, 2021), which later will contribute to the formation of the adult thoracic musculature.…”

Section: The Expression Of Antp During Embryogenesismentioning

confidence: 99%

Antennapedia: The complexity of a master developmental transcription factor

Rosales‐Vega,

Reséndez‐Pérez,

Vázquez

2023

Genesis

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SummaryHox genes encode transcription factors that play an important role in establishing the basic body plan of animals. In Drosophila, Antennapedia is one of the five genes that make up the Antennapedia complex (ANT‐C). Antennapedia determines the identity of the second thoracic segment, known as the mesothorax. Misexpression of Antennapedia at different developmental stages changes the identity of the mesothorax, including the muscles, nervous system, and cuticle. In Drosophila, Antennapedia has two distinct promoters highly regulated throughout development by several transcription factors. Antennapedia proteins are found with other transcription factors in different ANTENNAPEDIA transcriptional complexes to regulate multiple subsets of target genes. In this review, we describe the different mechanisms that regulate the expression and function of Antennapedia and the role of this Hox gene in the development of Drosophila.

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Hox Proteins in the Regulation of Muscle Development

Cited by 11 publications

References 129 publications

BdNub Is Essential for Maintaining gut Immunity and Microbiome Homeostasis in Bactrocera dorsalis

BdNub Is Essential for Maintaining gut Immunity and Microbiome Homeostasis in Bactrocera dorsalis

The 24-Hour Time Course of Integrated Molecular Responses to Resistance Exercise in Human Skeletal Muscle ImplicatesMYCas a Hypertrophic Regulator That is Sufficient for Growth

Antennapedia: The complexity of a master developmental transcription factor

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