Segregation Analysis of Ocular Refraction and Myopia

Ashton, G. C.

doi:10.1159/000153551

Cited by 68 publications

(26 citation statements)

References 9 publications

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“…Twin studies have shown high estimates of heritability for myopia [12][13][14] while family studies have resulted in consider ably lower estimates [15,16]. The present study uses, for the first time, a populationbased, unselected material for analysis of heritability in myopia.…”

Section: Discussionmentioning

confidence: 99%

Impact of Heredity in Myopia

Teikari¹,

O’Donnell²,

Kaprio³

et al. 1991

Hum Hered

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A series of 109 like-sexed twin pairs in the age group 30–31 years (54 monozygotic and 55 dizygotic) with one or both members of the twins with myopia was found in the Finnish Twin Cohort. The series was based on a random sample of 1,200 twins in one age stratum of the cohort. The twins received a questionnaire on their health status with special reference to eye diseases and symptoms. The refractive status of the twin pairs was ascertained by asking the twins to send their latest prescription for glasses to the authors or the refraction was obtained from the ophthalmologists or opticians of the twins. The mean difference in refraction between the monozygotic twins was 1.19 dptr in the right eyes and 1.15 dptr in the left eyes. The difference between dizygotic pairs was 2.34 dptr in the right eyes and 2.47 dptr in the left eyes. Analysis of variance showed that the difference in refraction between the two eyes of a twin pair was not significant. The mean difference in refraction between the monozygotic twins was significantly lower than that between dizygotic twins (p ≤ 0.001). The intrapair variances were doubled among dizygotic twin pairs compared to monozygotic twin pairs in the male group. The intrapair variance in the female group was 4-fold among dizygotic twin pairs as compared to monozygotic twin pairs. Heritability of myopia was 0.58 (0.74 for males and 0.61 for females) when myopia was considered a dichotomous variable. This result suggests that inheritance has a substantial effect on the etiology of myopia.

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Section: Discussionmentioning

confidence: 99%

Impact of Heredity in Myopia

Teikari¹,

O’Donnell²,

Kaprio³

et al. 1991

Hum Hered

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“…However, since this dominant transmission pattern was only evident in nine of the 36 families in Goldschmidt's cohort, it seems likely that other modes of inheritance of high myopia are more common than dominant inheritance. The failure to identify a major dominant myopia gene by segregation analysis36 is consistent with this view, although a recent study of the inheritance of corneal astigmatism37 suggests that this type of segregation analysis is not always capable of disclosing dominant gene effects.…”

mentioning

confidence: 84%

The heritability of high myopia: a reanalysis of Goldschmidt's data

Guggenheim¹,

Kirov²,

Hodson³

2000

Journal of Medical Genetics

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“…Family studies in both Asian [49,50,51,52] and Caucasian populations [49,53,54,55,56,57] have demonstrated that the parental refractive status plays an important role in the refractive status of their offspring.…”

Section: Pathological Myopiamentioning

confidence: 99%

Myopic Maculopathy: A Review

Silva

2012

Ophthalmologica

105

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Pathological myopia is a major cause of irreversible vision loss and is the fourth to ninth most frequent cause of blindness in the world. Choroidal neovascularization (CNV) secondary to pathological myopia is the leading cause of vision impairment in patients younger than 50 years. New scientific contributions have been made to the understanding of high myopia and associated CNV. New treatments have been used in recent years, and the results are still controversial. This paper is an updated review of pathological myopia – its definition and progression, epidemiology and genetics – and a review of myopic CNV including the natural history, epidemiology, risk factors, pathogenic mechanisms and treatment.

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Segregation Analysis of Ocular Refraction and Myopia

Cited by 68 publications

References 9 publications

Impact of Heredity in Myopia

Impact of Heredity in Myopia

The heritability of high myopia: a reanalysis of Goldschmidt's data

Myopic Maculopathy: A Review

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