Secundäre Cancroidinfiltration des Nervus mentalis bei einem Fall von Lippencancroid

Neumann, E.

doi:10.1007/bf01929317

Cited by 44 publications

(25 citation statements)

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“…21 PNI has been studied in many malignancies, including prostate cancer, head and neck cancer, and cancer in the gastrointestinal tract, 9,[22][23][24] yet there is still no agreement on a clear definition of PNI-positive. A stringent definition of PNI requires that tumor cells be observed inside the perineurial layer, 7 but this definition would not include the situation of tumor cells existing within epineurium.…”

Section: Discussionmentioning

confidence: 99%

Perineural invasion in pT3N0 rectal cancer

Peng

Sheng

Huang

et al. 2010

Cancer

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BACKGROUND:The authors' purpose was to explore the incidence and prognostic significance of perineural invasion (PNI) in pT3N0 rectal cancer. METHODS: Pathologic materials from resected specimens of 173 patients with pT3N0 rectal cancer were retrospectively collected. PNI-positivity was categorized into 2 groups: surrounding the nerve sheath (SS-PNI) and invading through the nerve sheath (TS-PNI). The rate of PNI-positivity was compared with PNI as initially recorded in the original reports. Patients' outcome was studied in groups with different PNI status, and multivariate analysis was performed to determine its prognostic value. RESULTS: In this retrospective analysis, PNIpositivity was found in 24.3% of all cases, in which SS-PNI and TS-PNI were 11% and 13.3%, respectively, and was related to lymphovascular invasion. Only 7.5% of patients' specimens were reported as PNI-positive in the original reports. Detection of SS-PNI was likelier to be missed than TS-PNI. The rates of local recurrence, disease-free survival, and overall survival at 5 years were similar between the groups of SS-PNI and TS-PNI. The 5-year local recurrence rate was more than 2.5-fold higher in the PNI-positive group compared with the PNI-negative group (22.7% vs 7.9%, respectively; P ¼ .017). Multivariate analysis proved that PNI-positivity was the only independent risk factor for predicting 5-year local recurrence rate, whereas only sampled lymph nodes was related to 5-year disease-free survival and overall survival. CONCLUSIONS: PNI is a common pathologic feature in rectal cancer. The definition of PNI should include SS-PNI and TS-PNI. Rectal cancer patients who are PNI-positive are at higher risk of local recurrence and should be considered for more intensive treatment.

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Section: Discussionmentioning

confidence: 99%

Perineural invasion in pT3N0 rectal cancer

Peng

Sheng

Huang

et al. 2010

Cancer

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“…Neumann 4 described the first cutaneous tumor with PNI in 1862. The frequency of PNI varies with histology; the incidence in SCC is between 2.5% and 5% and could approach 80% in microcystic adnexal carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Clinical Reasoning: An unusual cause of multiple cranial nerve impairment

et al. 2012

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“…mammary carcinoma growing along the facial nerve. The first report of PNS by a cutaneous malignancy is credited to Neumann 5 who, in 1862, described a lower lip carcinoma that spread along the mental nerve. In the early 20th century, it was believed that perineural lymphatics facilitated PNS by serving as channels between the peripheral lymph nodes and the subarachnoid space.…”

Section: Conclusion Previous Reportsmentioning

confidence: 99%

Perineural spread of cutaneous malignancy to the brain

Fowler

Crocker

Johnstone

2005

Cancer

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BACKGROUNDThe retrospective analysis was performed to investigate the role of stereotactic radiotherapy (SRT) techniques for patients with intracranial perineural spread (PNS) of a primary cutaneous malignancy.METHODSFive patients were identified who received SRT from 1993 to 2003 for cutaneous malignancies with intracranial PNS to the cavernous sinus (n = 3) or Meckel's cave (n = 2). Patients were treated with GammaKnife stereotactic radiosurgery (n = 2), linear accelerator (linac)‐based fractionated SRT (n = 2), or linac‐based stereotactic radiosurgery (n = 1).RESULTSThe median overall survival (OS) periods from diagnoses of cutaneous malignancy and intracranial PNS were 63.0 months (range, 22.0–102.2 months) and 25.5 months (range, 22.0–55.2 months), respectively. The median OS from SRT was 24.2 months (range, 19.5–53.2 months). One patient was alive and without evidence of disease at 53 months of follow‐up. The median durations of local and regional control from SRT were 19.5 months (range, 1.5–53.2 months) and 7.0 months (range, 1.5–53.2 months), respectively.CONCLUSIONSPrevious reports generally have recommended that patients with intracranial PNS receive palliative external‐beam radiotherapy. Results from the current study suggest that some of these patients may have prolonged survival, or even may be cured. Judicious use of SRT should be considered in their management. Cancer 2005. © 2005 American Cancer Society.

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Secundäre Cancroidinfiltration des Nervus mentalis bei einem Fall von Lippencancroid

Cited by 44 publications

References 0 publications

Perineural invasion in pT3N0 rectal cancer

Perineural invasion in pT3N0 rectal cancer

Clinical Reasoning: An unusual cause of multiple cranial nerve impairment

Perineural spread of cutaneous malignancy to the brain

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