Secular Utilitarianism

Crimmins, James E.

doi:10.1093/acprof:oso/9780198277415.001.0001

Cited by 102 publications

(9 citation statements)

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“…Lindlar hydrogenation 34 produced olefin 10 in excellent yield. Hydroboration-oxidation with 9-BBN 35 gave diol 11 in moderate yield. Parikh-Doering and subsequent Pinnick oxidations gave a mixture of the corresponding γ-hydroxy acid and lactone 12.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Biological Evaluation of Several Bryostatin Analogues Bearing a Diacylglycerol Lactone C-Ring

et al. 2016

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As an initial step in designing a simplified bryostatin hybrid molecule, three bryostatin analogues bearing a diacylglycerol lactone-based C-ring, which possessed the requisite pharmacophores for binding to protein kinase C (PKC) together with a modified bryostatin-like A- and B-ring region, were synthesized and evaluated. Merle 46 and Merle 47 exhibited binding affinity to PKC alpha with Ki values of 7000 ± 990 and 4940 ± 470 nM, respectively. Reinstallation of the trans-olefin and gem-dimethyl group present in bryostatin 1 in Merle 48 resulted in improved binding affinity, 363 ± 42 nM. While Merle 46 and 47 were only marginally active biologically, Merle 48 showed sufficient activity on the U937 cells to confirm that it was PMA-like for growth and attachment, as predicted by the substitution pattern of its A- and B-rings.

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Section: Resultsmentioning

confidence: 99%

Synthesis and Biological Evaluation of Several Bryostatin Analogues Bearing a Diacylglycerol Lactone C-Ring

et al. 2016

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“…The best results were obtained using conditions reported by Crimmins, in which N-methylpyrrolidinone (NMP) is used as a Lewis basic additive. 34 Under these conditions, yield is higher with shorter reaction times and elimination is suppressed at the expense of diastereoselectivity (Table 1 entries [4][5][6][7]. Due to difficulties associated with obtaining the diastereomer ratio (dr) from NMR spectroscopy, dr was determined by isolation in most cases.…”

Section: Resultsmentioning

confidence: 99%

Asymmetric Synthesis of Homocitric Acid Lactone

et al. 2016

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“…However, the UAVs are not amenable to capturing high-resolution images of small plants such as seedlings because they were designed to fly at specified altitudes above the ground, making it difficult to record detailed information for small plants [46,47]. Alternatively, small plants can be characterized using ground-based automated platforms at high-throughput phenotyping scales [48][49][50]. Image-based phenotyping offers a feasible tool to capture high-resolution images for evaluating seedling traits.…”

Section: Early-seedling Vigor and Regrowth Vigormentioning

confidence: 99%

Improving Dual-Purpose Winter Wheat in the Southern Great Plains of the United States

Maulana¹,

Anderson²,

Butler³

et al. 2020

Recent Advances in Grain Crops Research

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This chapter covers the production and breeding status of winter wheat (Triticum aestivum L.) used for early-season animal grazing and late-season grain production in the Southern Great Plains of the United States. Besides, in the chapter, the current production status and needs, the drawbacks of current cultivars, breeding strategies of the crop, novel genomics tools, and sensor technologies that can be used to improve dual-purpose winter wheat cultivars were presented. We will focus on traits that are, in general, not required by cultivars used for grain-only production but are critical for cool-season forage production.

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Secular Utilitarianism

Cited by 102 publications

References 0 publications

Synthesis and Biological Evaluation of Several Bryostatin Analogues Bearing a Diacylglycerol Lactone C-Ring

Synthesis and Biological Evaluation of Several Bryostatin Analogues Bearing a Diacylglycerol Lactone C-Ring

Asymmetric Synthesis of Homocitric Acid Lactone

Improving Dual-Purpose Winter Wheat in the Southern Great Plains of the United States

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