“…Overtreatment, especially with insufficient monitoring, may also lead to adverse events such as hypoglycemia, hypotension, or drug-drug interactions. However, given the multiple morbidities associated with diabetes, the high costs of cardiovascular-kidney complications, notably kidney failure, 365 and the proven benefits of control of cardiometabolic and lifestyle risk factors on these outcomes, 6,350,366 the Work Group judged that this upfront investment is likely to be translated to long-term benefits.…”