Diabetes and COVID‐19

Bloomgarden, Zachary T.

doi:10.1111/1753-0407.13027

Cited by 143 publications

(146 citation statements)

References 11 publications

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“…Both clinical (male sex, older age, previous lung or cardiovascular disease, obesity, hypertension) and biological (in ammation, coagulation) markers are associated with poor outcomes in COVID-19. Interestingly, conditions associated with metabolic disturbances, such as obesity or diabetes, are associated with a high risk of severe COVID-19 8,9 .…”

Section: Discussionmentioning

confidence: 99%

The specific metabolome profiling of patients infected by SARS-COV-2 supports the key role of tryptophan-nicotinamide pathway and cytosine metabolism

Blasco

BESSY²,

PLANTIER³

et al. 2020

Preprint

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BackgroundThe biological mechanisms involved in SARS-CoV-2 infection are only partially understood. Thus we explored the plasma metabolome of patients infected with SARS-CoV-2 to search for diagnostic and/or prognostic biomarkers and to improve the knowledge of metabolic disturbance in this infection.Materials and Methods We analyzed the plasma metabolome of 55 patients infected with SARS-CoV-2 and 45 controls by LC-HRMS at the time of diagnosis (D0). We first evaluated the ability to predict the diagnosis from the metabotype at D0 in an independent population. Next, we assessed the feasibility of predicting the disease evolution at the 7th and 15th day.ResultsPlasma metabolome allowed us to generate a discriminant multivariate model to predict the diagnosis of SARS-CoV-2 in an independent population (accuracy>74%, sensitivity, specificity>75%). We identified the role of the cytosine and tryptophan-nicotinamide pathways in this discrimination. However, metabolomic exploration modestly explained the disease evolution.DiscussionHere, we present the first metabolomic study in SARS-CoV-2 patients which showed a high reliable prediction of early diagnosis. We have highlighted the role of the tryptophan-nicotinamide pathway clearly linked to inflammatory signals and microbiota, and the involvement of cytosine, previously described as a coordinator of cell metabolism in SARS-CoV-2. These findings could open new therapeutic perspectives as indirect targets.

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Section: Discussionmentioning

confidence: 99%

The specific metabolome profiling of patients infected by SARS-COV-2 supports the key role of tryptophan-nicotinamide pathway and cytosine metabolism

Blasco

BESSY²,

PLANTIER³

et al. 2020

Preprint

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“…Factor for Severe COVID-19. Diabetes is a known risk factor for poorer outcome in patients who develop respiratory disease [28]; however, the association between diabetes and COVID-19 severity has not been examined systematically. We therefore performed a meta-analysis in order to examine the putative association between preexisting diabetes and COVID-19 severity.…”

Section: Preexisting Diabetes Is a Predictivementioning

confidence: 99%

Comorbid Chronic Diseases and Acute Organ Injuries Are Strongly Correlated with Disease Severity and Mortality among COVID-19 Patients: A Systemic Review and Meta-Analysis

et al. 2020

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The recent outbreak of COVID-19 has been rapidly spreading on a global scale. To date, there is no specific vaccine against the causative virus, SARS-CoV-2, nor is there an effective medicine for treating COVID-19, thus raising concerns with respect to the effect of risk factors such as clinical course and pathophysiological parameters on disease severity and outcome in patients with COVID-19. By extracting and analyzing all available published clinical data, we identified several major clinical characteristics associated with increased disease severity and mortality among patients with COVID-19. Specifically, preexisting chronic conditions such as hypertension, cardiovascular disease, chronic kidney disease, and diabetes are strongly associated with an increased risk of developing severe COVID-19; surprisingly, however, we found no correlation between chronic liver disease and increased disease severity. In addition, we found that both acute cardiac injury and acute kidney injury are highly correlated with an increased risk of COVID-19-related mortality. Given the high risk of comorbidity and the high mortality rate associated with tissue damage, organ function should be monitored closely in patients diagnosed with COVID-19, and this approach should be included when establishing new guidelines for managing these high-risk patients. Moreover, additional clinical data are needed in order to determine whether a supportive therapy can help mitigate the development of severe, potentially fatal complications, and further studies are needed to identify the pathophysiology and the mechanism underlying this novel coronavirus-associated infectious disease. Taken together, these findings provide new insights regarding clinical strategies for improving the management and outcome of patients with COVID-19.

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“…This disease firstly occurred in a province of China then spread worldwide [1]. Clinically, the disease usually presented with respiratory illness and death is a possible outcome [2,3]. The effect of COVID-19 is an interesting issue in audiology.…”

Section: Hearing Loss and Covid-19: A Notementioning

confidence: 99%